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Title: Biomarkers for liver fibrosis

Abstract

Methods and systems for diagnosing or prognosing liver fibrosis in a subject are provided. In some examples, such methods and systems can include detecting liver fibrosis-related molecules in a sample obtained from the subject, comparing expression of the molecules in the sample to controls representing expression values expected in a subject who does not have liver fibrosis or who has non-progressing fibrosis, and diagnosing or prognosing liver fibrosis in the subject when differential expression of the molecules between the sample and the controls is detected. Kits for the diagnosis or prognosis of liver fibrosis in a subject are also provided which include reagents for detecting liver fibrosis related molecules.

Inventors:
; ; ; ; ;
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1357507
Patent Number(s):
9,651,563
Application Number:
14/799,405
Assignee:
Battelle Memorial Institute PNNL
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Patent
Resource Relation:
Patent File Date: 2015 Jul 14
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Citation Formats

Jacobs, Jon M., Burnum-Johnson, Kristin E., Baker, Erin M., Smith, Richard D., Gritsenko, Marina A., and Orton, Daniel. Biomarkers for liver fibrosis. United States: N. p., 2017. Web.
Jacobs, Jon M., Burnum-Johnson, Kristin E., Baker, Erin M., Smith, Richard D., Gritsenko, Marina A., & Orton, Daniel. Biomarkers for liver fibrosis. United States.
Jacobs, Jon M., Burnum-Johnson, Kristin E., Baker, Erin M., Smith, Richard D., Gritsenko, Marina A., and Orton, Daniel. Tue . "Biomarkers for liver fibrosis". United States. doi:. https://www.osti.gov/servlets/purl/1357507.
@article{osti_1357507,
title = {Biomarkers for liver fibrosis},
author = {Jacobs, Jon M. and Burnum-Johnson, Kristin E. and Baker, Erin M. and Smith, Richard D. and Gritsenko, Marina A. and Orton, Daniel},
abstractNote = {Methods and systems for diagnosing or prognosing liver fibrosis in a subject are provided. In some examples, such methods and systems can include detecting liver fibrosis-related molecules in a sample obtained from the subject, comparing expression of the molecules in the sample to controls representing expression values expected in a subject who does not have liver fibrosis or who has non-progressing fibrosis, and diagnosing or prognosing liver fibrosis in the subject when differential expression of the molecules between the sample and the controls is detected. Kits for the diagnosis or prognosis of liver fibrosis in a subject are also provided which include reagents for detecting liver fibrosis related molecules.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue May 16 00:00:00 EDT 2017},
month = {Tue May 16 00:00:00 EDT 2017}
}

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Works referenced in this record:

Advancing the High Throughput Identification of Liver Fibrosis Protein Signatures Using Multiplexed Ion Mobility Spectrometry
journal, January 2014

  • Baker, Erin Shammel; Burnum-Johnson, Kristin E.; Jacobs, Jon M.
  • Molecular & Cellular Proteomics, Vol. 13, Issue 4, p. 1119-1127
  • DOI: 10.1074/mcp.M113.034595

Usefulness of a novel serum proteome-derived index FI-PRO (fibrosis-protein) in the prediction of fibrosis in chronic hepatitis C
journal, January 2011

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Serum proteomics and biomarker discovery across the spectrum of nonalcoholic fatty liver disease
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Diagnostic accuracy of a fibrosis serum panel (FIBRO Spect II) compared with Knodell and Ishak liver biopsy scores in chronic hepatitis C patients
journal, October 2006


HepatoProteomics: Applying proteomic technologies to the study of liver function and disease
journal, January 2006

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  • Hepatology, Vol. 44, Issue 2, p. 299-308
  • DOI: 10.1002/hep.21318

Noninvasive Tests for Liver Fibrosis
journal, November 2006

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Non-invasive assessment of chronic liver and gastric diseases
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journal, January 2006

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FibroTest and FibroScan for the Prediction of Hepatitis C-Related Fibrosis: A Systematic Review of Diagnostic Test Accuracy
journal, November 2007

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  • The American Journal of Gastroenterology, Vol. 102, Issue 11, p. 2589-2600
  • DOI: 10.1111/j.1572-0241.2007.01466.x