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Title: Biomarkers for liver fibrosis

Abstract

Methods and systems for diagnosing or prognosing liver fibrosis in a subject are provided. In some examples, such methods and systems can include detecting liver fibrosis-related molecules in a sample obtained from the subject, comparing expression of the molecules in the sample to controls representing expression values expected in a subject who does not have liver fibrosis or who has non-progressing fibrosis, and diagnosing or prognosing liver fibrosis in the subject when differential expression of the molecules between the sample and the controls is detected. Kits for the diagnosis or prognosis of liver fibrosis in a subject are also provided which include reagents for detecting liver fibrosis related molecules.

Inventors:
; ; ; ; ;
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1357507
Patent Number(s):
9,651,563
Application Number:
14/799,405
Assignee:
Battelle Memorial Institute PNNL
DOE Contract Number:
AC05-76RL01830
Resource Type:
Patent
Resource Relation:
Patent File Date: 2015 Jul 14
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Citation Formats

Jacobs, Jon M., Burnum-Johnson, Kristin E., Baker, Erin M., Smith, Richard D., Gritsenko, Marina A., and Orton, Daniel. Biomarkers for liver fibrosis. United States: N. p., 2017. Web.
Jacobs, Jon M., Burnum-Johnson, Kristin E., Baker, Erin M., Smith, Richard D., Gritsenko, Marina A., & Orton, Daniel. Biomarkers for liver fibrosis. United States.
Jacobs, Jon M., Burnum-Johnson, Kristin E., Baker, Erin M., Smith, Richard D., Gritsenko, Marina A., and Orton, Daniel. Tue . "Biomarkers for liver fibrosis". United States. doi:. https://www.osti.gov/servlets/purl/1357507.
@article{osti_1357507,
title = {Biomarkers for liver fibrosis},
author = {Jacobs, Jon M. and Burnum-Johnson, Kristin E. and Baker, Erin M. and Smith, Richard D. and Gritsenko, Marina A. and Orton, Daniel},
abstractNote = {Methods and systems for diagnosing or prognosing liver fibrosis in a subject are provided. In some examples, such methods and systems can include detecting liver fibrosis-related molecules in a sample obtained from the subject, comparing expression of the molecules in the sample to controls representing expression values expected in a subject who does not have liver fibrosis or who has non-progressing fibrosis, and diagnosing or prognosing liver fibrosis in the subject when differential expression of the molecules between the sample and the controls is detected. Kits for the diagnosis or prognosis of liver fibrosis in a subject are also provided which include reagents for detecting liver fibrosis related molecules.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue May 16 00:00:00 EDT 2017},
month = {Tue May 16 00:00:00 EDT 2017}
}

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