U.S. Department of EnergyOffice of Scientific and Technical Information
Resource for the Development of Biomedical Accelerator Mass Spectrometry (AMS)
Abstract
The NIH Research Resource for Biomedical AMS was originally funded at Lawrence Livermore National Laboratory in 1999 to develop and apply the technology of accelerator mass spectrometry (AMS) in broad- based biomedical research. The Resource’s niche is to fill needs for ultra high sensitivity quantitation when isotope-labeled agents are used. The Research Resource’s Technology Research and Development (TR&D) efforts will focus on the needs of the biomedical research community in the context of seven Driving Biomedical Projects (DBPs) that will drive the Center’s technical capabilities through three core TR&Ds. We will expand our present capabilities by developing a fully integrated HPLC AMS to increase our capabilities for metabolic measurements, we will develop methods to understand cellular processes and we will develop and validate methods for the application of AMS in human studies, which is a growing area of demand by collaborators and service users. In addition, we will continue to support new and ongoing collaborative and service projects that require the capabilities of the Resource. The Center will continue to train researchers in the use of the AMS capabilities being developed, and the results of all efforts will be widely disseminated to advance progress in biomedical research. Towards these goals,more »
- Authors:
-
- Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
- Publication Date:
- Research Org.:
- Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1357338
- Report Number(s):
- LLNL-TR-727368
- DOE Contract Number:
- AC52-07NA27344
- Resource Type:
- Technical Report
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY
Citation Formats
Tuerteltaub, K. W., Bench, G., Buchholz, B. A., Enright, H., Kulp, K., Loots, G. G., McCartt, A. D., Malfatti, M., Ognibene, T., and Stewart, B. J. Resource for the Development of Biomedical Accelerator Mass Spectrometry (AMS). United States: N. p., 2017.
Web. doi:10.2172/1357338.
Tuerteltaub, K. W., Bench, G., Buchholz, B. A., Enright, H., Kulp, K., Loots, G. G., McCartt, A. D., Malfatti, M., Ognibene, T., & Stewart, B. J. Resource for the Development of Biomedical Accelerator Mass Spectrometry (AMS). United States. https://doi.org/10.2172/1357338
Tuerteltaub, K. W., Bench, G., Buchholz, B. A., Enright, H., Kulp, K., Loots, G. G., McCartt, A. D., Malfatti, M., Ognibene, T., and Stewart, B. J. 2017.
"Resource for the Development of Biomedical Accelerator Mass Spectrometry (AMS)". United States. https://doi.org/10.2172/1357338. https://www.osti.gov/servlets/purl/1357338.
@article{osti_1357338,
title = {Resource for the Development of Biomedical Accelerator Mass Spectrometry (AMS)},
author = {Tuerteltaub, K. W. and Bench, G. and Buchholz, B. A. and Enright, H. and Kulp, K. and Loots, G. G. and McCartt, A. D. and Malfatti, M. and Ognibene, T. and Stewart, B. J.},
abstractNote = {The NIH Research Resource for Biomedical AMS was originally funded at Lawrence Livermore National Laboratory in 1999 to develop and apply the technology of accelerator mass spectrometry (AMS) in broad- based biomedical research. The Resource’s niche is to fill needs for ultra high sensitivity quantitation when isotope-labeled agents are used. The Research Resource’s Technology Research and Development (TR&D) efforts will focus on the needs of the biomedical research community in the context of seven Driving Biomedical Projects (DBPs) that will drive the Center’s technical capabilities through three core TR&Ds. We will expand our present capabilities by developing a fully integrated HPLC AMS to increase our capabilities for metabolic measurements, we will develop methods to understand cellular processes and we will develop and validate methods for the application of AMS in human studies, which is a growing area of demand by collaborators and service users. In addition, we will continue to support new and ongoing collaborative and service projects that require the capabilities of the Resource. The Center will continue to train researchers in the use of the AMS capabilities being developed, and the results of all efforts will be widely disseminated to advance progress in biomedical research. Towards these goals, our specific aims are to:1.) Increase the value and information content of AMS measurements by combining molecular speciation with quantitation of defined macromolecular isolates. Specifically, develop and validate methods for macromolecule labeling, characterization and quantitation.2.) Develop and validate methods and strategies to enable AMS to become more broadly used in human studies. Specifically, demonstrate robust methods for conducting pharmacokinetic/pharmacodynamics studies in humans and model systems.3.) Increase the accessibility of AMS to the Biomedical research community and the throughput of AMS through direct coupling to separatory instruments.4.) Provide high throughput 14C BioAMS analysis for collaborative and service clients.},
doi = {10.2172/1357338},
url = {https://www.osti.gov/biblio/1357338},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Mar 21 00:00:00 EDT 2017},
month = {Tue Mar 21 00:00:00 EDT 2017}
}