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Title: Visualizing multistep elevator-like transitions of a nucleoside transporter

Authors:
; ;
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
National Institutes of Health (NIH)
OSTI Identifier:
1356404
Resource Type:
Journal Article
Journal Name:
Nature (London)
Additional Journal Information:
Journal Volume: 545; Journal Issue: 7652; Journal ID: ISSN 0028-0836
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Hirschi, Marscha, Johnson, Zachary Lee, and Lee, Seok-Yong. Visualizing multistep elevator-like transitions of a nucleoside transporter. United States: N. p., 2017. Web. doi:10.1038/nature22057.
Hirschi, Marscha, Johnson, Zachary Lee, & Lee, Seok-Yong. Visualizing multistep elevator-like transitions of a nucleoside transporter. United States. doi:10.1038/nature22057.
Hirschi, Marscha, Johnson, Zachary Lee, and Lee, Seok-Yong. Mon . "Visualizing multistep elevator-like transitions of a nucleoside transporter". United States. doi:10.1038/nature22057.
@article{osti_1356404,
title = {Visualizing multistep elevator-like transitions of a nucleoside transporter},
author = {Hirschi, Marscha and Johnson, Zachary Lee and Lee, Seok-Yong},
abstractNote = {},
doi = {10.1038/nature22057},
journal = {Nature (London)},
issn = {0028-0836},
number = 7652,
volume = 545,
place = {United States},
year = {2017},
month = {4}
}

Works referenced in this record:

Transport mechanism of a bacterial homologue of glutamate transporters
journal, November 2009

  • Reyes, Nicolas; Ginter, Christopher; Boudker, Olga
  • Nature, Vol. 462, Issue 7275
  • DOI: 10.1038/nature08616

Toward the structural genomics of complexes: Crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis
journal, May 2006

  • Strong, M.; Sawaya, M. R.; Wang, S.
  • Proceedings of the National Academy of Sciences, Vol. 103, Issue 21
  • DOI: 10.1073/pnas.0602606103

Mechanism of Na+-dependent citrate transport from the structure of an asymmetrical CitS dimer
journal, December 2015

  • Wöhlert, David; Grötzinger, Maria J.; Kühlbrandt, Werner
  • eLife, Vol. 4
  • DOI: 10.7554/eLife.09375

iMOSFLM : a new graphical interface for diffraction-image processing with MOSFLM
journal, March 2011

  • Battye, T. Geoff G.; Kontogiannis, Luke; Johnson, Owen
  • Acta Crystallographica Section D Biological Crystallography, Vol. 67, Issue 4
  • DOI: 10.1107/S0907444910048675

Unsynchronised subunit motion in single trimeric sodium-coupled aspartate transporters
journal, October 2013

  • Erkens, Guus B.; Hänelt, Inga; Goudsmits, Joris M. H.
  • Nature, Vol. 502, Issue 7469
  • DOI: 10.1038/nature12538

The Structure of a Sugar Transporter of the Glucose EIIC Superfamily Provides Insight into the Elevator Mechanism of Membrane Transport
journal, June 2016


Simple Allosteric Model for Membrane Pumps
journal, August 1966


The Rocking Bundle: A Mechanism for Ion-Coupled Solute Flux by Symmetrical Transporters
journal, December 2009


Transport domain unlocking sets the uptake rate of an aspartate transporter
journal, February 2015

  • Akyuz, Nurunisa; Georgieva, Elka R.; Zhou, Zhou
  • Nature, Vol. 518, Issue 7537
  • DOI: 10.1038/nature14158

MolProbity : all-atom structure validation for macromolecular crystallography
journal, December 2009

  • Chen, Vincent B.; Arendall, W. Bryan; Headd, Jeffrey J.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 1
  • DOI: 10.1107/S0907444909042073

Coot model-building tools for molecular graphics
journal, November 2004

  • Emsley, Paul; Cowtan, Kevin
  • Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12, p. 2126-2132
  • DOI: 10.1107/S0907444904019158

The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29
journal, April 2013

  • Young, James D.; Yao, Sylvia Y. M.; Baldwin, Jocelyn M.
  • Molecular Aspects of Medicine, Vol. 34, Issue 2-3
  • DOI: 10.1016/j.mam.2012.05.007

Unlocking the molecular secrets of sodium-coupled transporters
journal, May 2009

  • Krishnamurthy, Harini; Piscitelli, Chayne L.; Gouaux, Eric
  • Nature, Vol. 459, Issue 7245
  • DOI: 10.1038/nature08143

PHENIX: a comprehensive Python-based system for macromolecular structure solution
journal, January 2010

  • Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221
  • DOI: 10.1107/S0907444909052925

The structural basis of secondary active transport mechanisms
journal, February 2011

  • Forrest, Lucy R.; Krämer, Reinhard; Ziegler, Christine
  • Biochimica et Biophysica Acta (BBA) - Bioenergetics, Vol. 1807, Issue 2
  • DOI: 10.1016/j.bbabio.2010.10.014

A General Theory of Membrane Transport From Studies of Bacteria
journal, July 1957


Conformational heterogeneity of the aspartate transporter GltPh
journal, January 2013

  • Hänelt, Inga; Wunnicke, Dorith; Bordignon, Enrica
  • Nature Structural & Molecular Biology, Vol. 20, Issue 2
  • DOI: 10.1038/nsmb.2471

Crystal structures reveal the molecular basis of ion translocation in sodium/proton antiporters
journal, February 2016

  • Coincon, Mathieu; Uzdavinys, Povilas; Nji, Emmanuel
  • Nature Structural & Molecular Biology, Vol. 23, Issue 3
  • DOI: 10.1038/nsmb.3164

Structure of a glutamate transporter homologue from Pyrococcus horikoshii
journal, October 2004

  • Yernool, Dinesh; Boudker, Olga; Jin, Yan
  • Nature, Vol. 431, Issue 7010
  • DOI: 10.1038/nature03018

Shared Molecular Mechanisms of Membrane Transporters
journal, June 2016


Atomic Structures of the Human Immunophilin FKBP-12 Complexes with FK506 and Rapamycin
journal, January 1993

  • Van Duyne, Gregory D.; Standaert, Robert F.; Karplus, P. Andrew
  • Journal of Molecular Biology, Vol. 229, Issue 1
  • DOI: 10.1006/jmbi.1993.1012


journal, October 2009

  • Molina-Arcas, Miriam; Casado, F.; Pastor-Anglada, Marcal
  • Current Vascular Pharmacology, Vol. 7, Issue 4
  • DOI: 10.2174/157016109789043892

Transport dynamics in a glutamate transporter homologue
journal, June 2013

  • Akyuz, Nurunisa; Altman, Roger B.; Blanchard, Scott C.
  • Nature, Vol. 502, Issue 7469
  • DOI: 10.1038/nature12265

Crystal structure of a concentrative nucleoside transporter from Vibrio cholerae at 2.4 Å
journal, March 2012

  • Johnson, Zachary Lee; Cheong, Cheom-Gil; Lee, Seok-Yong
  • Nature, Vol. 483, Issue 7390
  • DOI: 10.1038/nature10882

Inward-facing conformation of glutamate transporters as revealed by their inverted-topology structural repeats
journal, November 2009

  • Crisman, T. J.; Qu, S.; Kanner, B. I.
  • Proceedings of the National Academy of Sciences, Vol. 106, Issue 49
  • DOI: 10.1073/pnas.0908570106

Repeat-swap homology modeling of secondary active transporters: updated protocol and prediction of elevator-type mechanisms
journal, September 2015

  • Vergara-Jaque, Ariela; Fenollar-Ferrer, Cristina; Kaufmann, Desirée
  • Frontiers in Pharmacology, Vol. 6
  • DOI: 10.3389/fphar.2015.00183

XDS
journal, January 2010

  • Kabsch, Wolfgang
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2
  • DOI: 10.1107/S0907444909047337

Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters
journal, July 2014


Phaser crystallographic software
journal, July 2007

  • McCoy, Airlie J.; Grosse-Kunstleve, Ralf W.; Adams, Paul D.
  • Journal of Applied Crystallography, Vol. 40, Issue 4
  • DOI: 10.1107/S0021889807021206