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Title: Spectroscopic quantification of extremely rare molecular species in the presence of interfering optical absorption

Abstract

Optical spectrometer apparatus, systems, and methods for analysis of carbon-14 including a resonant optical cavity configured to accept a sample gas including carbon-14, an optical source configured to deliver optical radiation to the resonant optical cavity, an optical detector configured to detect optical radiation emitted from the resonant cavity and to provide a detector signal; and a processor configured to compute a carbon-14 concentration from the detector signal, wherein computing the carbon-14 concentration from the detector signal includes fitting a spectroscopic model to a measured spectrogram, wherein the spectroscopic model accounts for contributions from one or more interfering species that spectroscopically interfere with carbon-14.

Inventors:
; ; ; ; ; ; ;
Publication Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1356288
Patent Number(s):
9,645,077
Application Number:
14/714,658
Assignee:
Lawrence Livermore National Security, LLC LLNL
DOE Contract Number:
AC52-07NA27344
Resource Type:
Patent
Resource Relation:
Patent File Date: 2015 May 18
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE

Citation Formats

Ognibene, Ted, Bench, Graham, McCartt, Alan Daniel, Turteltaub, Kenneth, Rella, Chris W., Tan, Sze, Hoffnagle, John A., and Crosson, Eric. Spectroscopic quantification of extremely rare molecular species in the presence of interfering optical absorption. United States: N. p., 2017. Web.
Ognibene, Ted, Bench, Graham, McCartt, Alan Daniel, Turteltaub, Kenneth, Rella, Chris W., Tan, Sze, Hoffnagle, John A., & Crosson, Eric. Spectroscopic quantification of extremely rare molecular species in the presence of interfering optical absorption. United States.
Ognibene, Ted, Bench, Graham, McCartt, Alan Daniel, Turteltaub, Kenneth, Rella, Chris W., Tan, Sze, Hoffnagle, John A., and Crosson, Eric. Tue . "Spectroscopic quantification of extremely rare molecular species in the presence of interfering optical absorption". United States. doi:. https://www.osti.gov/servlets/purl/1356288.
@article{osti_1356288,
title = {Spectroscopic quantification of extremely rare molecular species in the presence of interfering optical absorption},
author = {Ognibene, Ted and Bench, Graham and McCartt, Alan Daniel and Turteltaub, Kenneth and Rella, Chris W. and Tan, Sze and Hoffnagle, John A. and Crosson, Eric},
abstractNote = {Optical spectrometer apparatus, systems, and methods for analysis of carbon-14 including a resonant optical cavity configured to accept a sample gas including carbon-14, an optical source configured to deliver optical radiation to the resonant optical cavity, an optical detector configured to detect optical radiation emitted from the resonant cavity and to provide a detector signal; and a processor configured to compute a carbon-14 concentration from the detector signal, wherein computing the carbon-14 concentration from the detector signal includes fitting a spectroscopic model to a measured spectrogram, wherein the spectroscopic model accounts for contributions from one or more interfering species that spectroscopically interfere with carbon-14.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue May 09 00:00:00 EDT 2017},
month = {Tue May 09 00:00:00 EDT 2017}
}

Patent:

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  • An oxygen concentration measurement system for blood hemoglobin comprises a multiple-wavelength low-coherence optical light source that is coupled by single mode fibers through a splitter and combiner and focused on both a target tissue sample and a reference mirror. Reflections from both the reference mirror and from the depths of the target tissue sample are carried back and mixed to produce interference fringes in the splitter and combiner. The reference mirror is set such that the distance traversed in the reference path is the same as the distance traversed into and back from the target tissue sample at some depthmore » in the sample that will provide light attenuation information that is dependent on the oxygen in blood hemoglobin in the target tissue sample. Two wavelengths of light are used to obtain concentrations. The method can be used to measure total hemoglobin concentration [Hb.sub.deoxy +Hb.sub.oxy ] or total blood volume in tissue and in conjunction with oxygen saturation measurements from pulse oximetry can be used to absolutely quantify oxyhemoglobin [HbO.sub.2 ] in tissue. The apparatus and method provide a general means for absolute quantitation of an absorber dispersed in a highly scattering medium.« less
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