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Host cells and methods for producing 1-deoxyxylulose 5-phosphate (DXP) and/or a DXP derived compound

Patent ·
OSTI ID:1354809
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The present invention provides for a genetically modified host cell capable of producing 1-deoxyxylulose 5-phosphate or 1-deoxy-D-xylulose 5-phosphate (DXP) (12), and optionally one or more DXP derived compounds, comprising: (a) a mutant RibB, or functional variant thereof, capable of catalyzing xylulose 5-phoshpate and/or ribulose 5-phospate to DXP, or (b) a YajO, or functional variant thereof, and a XylB, or functional variant thereof.

Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC02-05CH11231
Assignee:
The Regents of the University of California
Patent Number(s):
9,637,766
Application Number:
15/186,202
OSTI ID:
1354809
Country of Publication:
United States
Language:
English

References (8)

Conversion of Methylglyoxal to Acetol by Escherichia coli Aldo-Keto Reductases journal August 2005
A mutant pyruvate dehydrogenase E1 subunit allows survival of Escherichia coli strains defective in 1-deoxy- d -xylulose 5-phosphate synthase journal January 2006
Computational Analysis of the Evolution of 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase, an Important Enzyme in Plant Terpene Biosynthesis journal May 2010
Mutations in Escherichia coli aceE and ribB Genes Allow Survival of Strains Defective in the First Step of the Isoprenoid Biosynthesis Pathway journal August 2012
Mono and diterpene production in Escherichia coli journal January 2004
Identification of Isopentenol Biosynthetic Genes from Bacillus subtilis by a Screening Method Based on Isoprenoid Precursor Toxicity journal August 2007
Phosphorylation of 1-deoxy-D-xylulose by D-xylulokinase of Escherichia coli: journal January 2001
Biosynthesis of isoprenoids via the non-mevalonate pathway journal June 2004

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