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Title: Microbiome-wide association studies link dynamic microbial consortia to disease

Abstract

Rapid advances in DNA sequencing, metabolomics, proteomics and computational tools are dramatically increasing access to the microbiome and identification of its links with disease. In particular, time-series studies and multiple molecular perspectives are facilitating microbiome-wide association studies, which are analogous to genome-wide association studies. Early findings point to actionable outcomes of microbiome-wide association studies, although their clinical application has yet to be approved. An appreciation of the complexity of interactions among the microbiome and the host's diet, chemistry and health, as well as determining the frequency of observations that are needed to capture and integrate this dynamic interface, is paramount for developing precision diagnostics and therapies that are based on the microbiome.

Authors:
; ; ; ; ; ; ; ;
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1353345
Report Number(s):
PNNL-SA-116462
Journal ID: ISSN 0028-0836
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Journal Article
Resource Relation:
Journal Name: Nature (London); Journal Volume: 535; Journal Issue: 7610
Country of Publication:
United States
Language:
English

Citation Formats

Gilbert, Jack A., Quinn, Robert A., Debelius, Justine, Xu, Zhenjiang Z., Morton, James, Garg, Neha, Jansson, Janet K., Dorrestein, Pieter C., and Knight, Rob. Microbiome-wide association studies link dynamic microbial consortia to disease. United States: N. p., 2016. Web. doi:10.1038/nature18850.
Gilbert, Jack A., Quinn, Robert A., Debelius, Justine, Xu, Zhenjiang Z., Morton, James, Garg, Neha, Jansson, Janet K., Dorrestein, Pieter C., & Knight, Rob. Microbiome-wide association studies link dynamic microbial consortia to disease. United States. doi:10.1038/nature18850.
Gilbert, Jack A., Quinn, Robert A., Debelius, Justine, Xu, Zhenjiang Z., Morton, James, Garg, Neha, Jansson, Janet K., Dorrestein, Pieter C., and Knight, Rob. Wed . "Microbiome-wide association studies link dynamic microbial consortia to disease". United States. doi:10.1038/nature18850.
@article{osti_1353345,
title = {Microbiome-wide association studies link dynamic microbial consortia to disease},
author = {Gilbert, Jack A. and Quinn, Robert A. and Debelius, Justine and Xu, Zhenjiang Z. and Morton, James and Garg, Neha and Jansson, Janet K. and Dorrestein, Pieter C. and Knight, Rob},
abstractNote = {Rapid advances in DNA sequencing, metabolomics, proteomics and computational tools are dramatically increasing access to the microbiome and identification of its links with disease. In particular, time-series studies and multiple molecular perspectives are facilitating microbiome-wide association studies, which are analogous to genome-wide association studies. Early findings point to actionable outcomes of microbiome-wide association studies, although their clinical application has yet to be approved. An appreciation of the complexity of interactions among the microbiome and the host's diet, chemistry and health, as well as determining the frequency of observations that are needed to capture and integrate this dynamic interface, is paramount for developing precision diagnostics and therapies that are based on the microbiome.},
doi = {10.1038/nature18850},
journal = {Nature (London)},
number = 7610,
volume = 535,
place = {United States},
year = {Wed Jul 06 00:00:00 EDT 2016},
month = {Wed Jul 06 00:00:00 EDT 2016}
}