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Title: Knowns and unknowns in metabolomics identified by multidimensional NMR and hybrid MS/NMR methods

Abstract

Metabolomics continues to make rapid progress through the development of new and better methods and their applications to gain insight into the metabolism of a wide range of different biological systems from a systems biology perspective. Customization of NMR databases and search tools allows the faster and more accurate identification of known metabolites, whereas the identification of unknowns, without a need for extensive purification, requires new strategies to integrate NMR with mass spectrometry, cheminformatics, and computational methods. For some applications, the use of covalent and non-covalent attachments in the form of labeled tags or nanoparticles can significantly reduce the complexity of these tasks.

Authors:
;
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1353309
Report Number(s):
PNNL-SA-119034
Journal ID: ISSN 0958-1669
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Journal Article
Resource Relation:
Journal Name: Current Opinion in Biotechnology; Journal Volume: 43
Country of Publication:
United States
Language:
English

Citation Formats

Bingol, Kerem, and Brüschweiler, Rafael. Knowns and unknowns in metabolomics identified by multidimensional NMR and hybrid MS/NMR methods. United States: N. p., 2017. Web. doi:10.1016/j.copbio.2016.07.006.
Bingol, Kerem, & Brüschweiler, Rafael. Knowns and unknowns in metabolomics identified by multidimensional NMR and hybrid MS/NMR methods. United States. doi:10.1016/j.copbio.2016.07.006.
Bingol, Kerem, and Brüschweiler, Rafael. Wed . "Knowns and unknowns in metabolomics identified by multidimensional NMR and hybrid MS/NMR methods". United States. doi:10.1016/j.copbio.2016.07.006.
@article{osti_1353309,
title = {Knowns and unknowns in metabolomics identified by multidimensional NMR and hybrid MS/NMR methods},
author = {Bingol, Kerem and Brüschweiler, Rafael},
abstractNote = {Metabolomics continues to make rapid progress through the development of new and better methods and their applications to gain insight into the metabolism of a wide range of different biological systems from a systems biology perspective. Customization of NMR databases and search tools allows the faster and more accurate identification of known metabolites, whereas the identification of unknowns, without a need for extensive purification, requires new strategies to integrate NMR with mass spectrometry, cheminformatics, and computational methods. For some applications, the use of covalent and non-covalent attachments in the form of labeled tags or nanoparticles can significantly reduce the complexity of these tasks.},
doi = {10.1016/j.copbio.2016.07.006},
journal = {Current Opinion in Biotechnology},
number = ,
volume = 43,
place = {United States},
year = {Wed Feb 01 00:00:00 EST 2017},
month = {Wed Feb 01 00:00:00 EST 2017}
}