Membrane tension feedback on shape and motility of eukaryotic cells

Journal Article · Fri Apr 01 00:00:00 EDT 2016 · Physica. D, Nonlinear Phenomena

DOI:https://doi.org/10.1016/j.physd.2015.09.011· OSTI ID:1352854

Winkler, Benjamin; Aranson, Igor S.; Ziebert, Falko

In the framework of a phase field model of a single cell crawling on a substrate, we investigate how the properties of the cell membrane affect the shape and motility of the cell. Since the membrane influences the cell dynamics on multiple levels and provides a nontrivial feedback, we consider the following fundamental interactions: (i) the reduction of the actin polymerization rate by membrane tension; (ii) area conservation of the cell’s two-dimensional cross-section vs. conservation of the circumference (i.e. membrane inextensibility); and (iii) the contribution from the membrane’s bending energy to the shape and integrity of the cell. As in experiments, we investigate two pertinent observables — the cell’s velocity and its aspect ratio. We find that the most important effect is the feedback of membrane tension on the actin polymerization. Bending rigidity has only minor effects, visible mostly in dynamic reshaping events, as exemplified by collisions of the cell with an obstacle.

• Research Organization: Argonne National Lab. (ANL), Argonne, IL (United States)
• Sponsoring Organization: USDOE Office of Science (SC), Basic Energy Sciences (BES)
• DOE Contract Number: AC02-06CH11357
• OSTI ID: 1352854
• Journal Information: Physica. D, Nonlinear Phenomena, Vol. 318-319; ISSN 0167-2789
• Publisher: Elsevier
• Country of Publication: United States
• Language: English