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Title: Proton induced production and radiochemical isolation of 44Ti from scandium metal targets for 44Ti/ 44Sc generator development

Abstract

Scandium-44 g (half-life 3.97 h) shows promise for application in positron emission tomography (PET), due to favorable decay parameters. One of the sources of 44gSc is the 44Ti/ 44gSc generator, which can conveniently provide this radioisotope on a daily basis at a diagnostic facility. Titanium-44 (half-life 60.0 a), in turn, can be obtained via proton irradiation of scandium metal targets. A substantial 44Ti product batch, however, requires high beam currents, long irradiation times and an elaborate chemical procedure for 44Ti isolation and purification. This study describes the production of a combined 175 MBq (4.7 mCi) batch yield of 44Ti in week long proton irradiations at the Los Alamos Isotope Production Facility (LANL-IPF) and the Brookhaven Linac Isotope Producer (BNL-BLIP). A two-step ion exchange chromatography based chemical separation method is introduced: first, a coarse separation of 44Ti via anion exchange sorption in concentrated HCl results in a 44Tc/Sc separation factor of 10 2–10 3. A second, cation exchange based step in HCl media is then applied for 44Ti fine purification from residual Sc mass. In conclusion, this method yields a 90–97% 44Ti recovery with an overall Ti/Sc separation factor of ≥10 6.

Authors:
 [1];  [1];  [2];  [1];  [1];  [1];  [1]; ORCiD logo [1];  [1];  [2];  [2]; ORCiD logo [1]; ORCiD logo [1]; ORCiD logo [1]; ORCiD logo [1]
  1. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
  2. Brookhaven National Lab. (BNL), Upton, NY (United States). Collider-Accelerator Dept.
Publication Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE Office of Science (SC). Nuclear Physics (NP) (SC-26); USDOE Office of Science (SC), Nuclear Physics (NP) (SC-26)
OSTI Identifier:
1352426
Alternate Identifier(s):
OSTI ID: 1361398; OSTI ID: 1415250
Report Number(s):
LA-UR-16-29428; BNL-113861-2017-JA
Journal ID: ISSN 0969-8051; TRN: US1700548
Grant/Contract Number:
AC52-06NA25396; SC00112704
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Nuclear Medicine and Biology
Additional Journal Information:
Journal Volume: 50; Journal ID: ISSN 0969-8051
Publisher:
Elsevier
Country of Publication:
United States
Language:
English
Subject:
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; Analytical Chemistry; Inorganic and Physical Chemistry; 43 PARTICLE ACCELERATORS; 44Ti; scandium target; ion exchange chromatography; proton irradiation; 44Ti/44gSc generator

Citation Formats

Radchenko, Valery, Engle, Jonathan Ward, Medvedev, Dmitri G., Maassen, Joel M., Naranjo, Cleo Micah, Unc, George A., Meyer, Catherine A.L., Mastren, Tara, Brugh, Mark, Mausner, Leonard, Cutler, Catherine S., Birnbaum, Eva R., John, Kevin Dale, Nortier, Francois Meiring, and Fassbender, Michael Ernst. Proton induced production and radiochemical isolation of 44Ti from scandium metal targets for 44Ti/44Sc generator development. United States: N. p., 2017. Web. doi:10.1016/j.nucmedbio.2017.03.006.
Radchenko, Valery, Engle, Jonathan Ward, Medvedev, Dmitri G., Maassen, Joel M., Naranjo, Cleo Micah, Unc, George A., Meyer, Catherine A.L., Mastren, Tara, Brugh, Mark, Mausner, Leonard, Cutler, Catherine S., Birnbaum, Eva R., John, Kevin Dale, Nortier, Francois Meiring, & Fassbender, Michael Ernst. Proton induced production and radiochemical isolation of 44Ti from scandium metal targets for 44Ti/44Sc generator development. United States. doi:10.1016/j.nucmedbio.2017.03.006.
Radchenko, Valery, Engle, Jonathan Ward, Medvedev, Dmitri G., Maassen, Joel M., Naranjo, Cleo Micah, Unc, George A., Meyer, Catherine A.L., Mastren, Tara, Brugh, Mark, Mausner, Leonard, Cutler, Catherine S., Birnbaum, Eva R., John, Kevin Dale, Nortier, Francois Meiring, and Fassbender, Michael Ernst. Fri . "Proton induced production and radiochemical isolation of 44Ti from scandium metal targets for 44Ti/44Sc generator development". United States. doi:10.1016/j.nucmedbio.2017.03.006. https://www.osti.gov/servlets/purl/1352426.
@article{osti_1352426,
title = {Proton induced production and radiochemical isolation of 44Ti from scandium metal targets for 44Ti/44Sc generator development},
author = {Radchenko, Valery and Engle, Jonathan Ward and Medvedev, Dmitri G. and Maassen, Joel M. and Naranjo, Cleo Micah and Unc, George A. and Meyer, Catherine A.L. and Mastren, Tara and Brugh, Mark and Mausner, Leonard and Cutler, Catherine S. and Birnbaum, Eva R. and John, Kevin Dale and Nortier, Francois Meiring and Fassbender, Michael Ernst},
abstractNote = {Scandium-44 g (half-life 3.97 h) shows promise for application in positron emission tomography (PET), due to favorable decay parameters. One of the sources of 44gSc is the 44Ti/44gSc generator, which can conveniently provide this radioisotope on a daily basis at a diagnostic facility. Titanium-44 (half-life 60.0 a), in turn, can be obtained via proton irradiation of scandium metal targets. A substantial 44Ti product batch, however, requires high beam currents, long irradiation times and an elaborate chemical procedure for 44Ti isolation and purification. This study describes the production of a combined 175 MBq (4.7 mCi) batch yield of 44Ti in week long proton irradiations at the Los Alamos Isotope Production Facility (LANL-IPF) and the Brookhaven Linac Isotope Producer (BNL-BLIP). A two-step ion exchange chromatography based chemical separation method is introduced: first, a coarse separation of 44Ti via anion exchange sorption in concentrated HCl results in a 44Tc/Sc separation factor of 102–103. A second, cation exchange based step in HCl media is then applied for 44Ti fine purification from residual Sc mass. In conclusion, this method yields a 90–97% 44Ti recovery with an overall Ti/Sc separation factor of ≥106.},
doi = {10.1016/j.nucmedbio.2017.03.006},
journal = {Nuclear Medicine and Biology},
number = ,
volume = 50,
place = {United States},
year = {Fri Apr 07 00:00:00 EDT 2017},
month = {Fri Apr 07 00:00:00 EDT 2017}
}

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