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Title: Host cells and methods for production of isobutanol

Abstract

Provided herein are recombinant yeast host cells and methods for their use for production of isobutanol. Yeast host cells provided comprise an isobutanol biosynthetic pathway and at least one of reduced or eliminated aldehyde dehydrogenase activity, reduced or eliminated acetolactate reductase activity; or a heterologous polynucleotide encoding a polypeptide having ketol-acid reductoisomerase activity.

Inventors:
; ; ; ; ; ; ; ; ; ;
Publication Date:
Research Org.:
Butamax Advanced Biofuels LLC, Wilmington, DE (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1351895
Patent Number(s):
9,422,581
Application Number:
13/840,649
Assignee:
Butamax Advanced Biofuels LLC (Wilmington, DE) ARPA-E
DOE Contract Number:  
AR0000006
Resource Type:
Patent
Resource Relation:
Patent File Date: 2013 Mar 15
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 09 BIOMASS FUELS

Citation Formats

Anthony, Larry Cameron, He, Hongxian, Huang, Lixuan Lisa, Okeefe, Daniel P., Kruckeberg, Arthur Leo, Li, Yougen, Maggio-Hall, Lori Ann, McElvain, Jessica, Nelson, Mark J., Patnaik, Ranjan, and Rothman, Steven Cary. Host cells and methods for production of isobutanol. United States: N. p., 2016. Web.
Anthony, Larry Cameron, He, Hongxian, Huang, Lixuan Lisa, Okeefe, Daniel P., Kruckeberg, Arthur Leo, Li, Yougen, Maggio-Hall, Lori Ann, McElvain, Jessica, Nelson, Mark J., Patnaik, Ranjan, & Rothman, Steven Cary. Host cells and methods for production of isobutanol. United States.
Anthony, Larry Cameron, He, Hongxian, Huang, Lixuan Lisa, Okeefe, Daniel P., Kruckeberg, Arthur Leo, Li, Yougen, Maggio-Hall, Lori Ann, McElvain, Jessica, Nelson, Mark J., Patnaik, Ranjan, and Rothman, Steven Cary. Tue . "Host cells and methods for production of isobutanol". United States. doi:. https://www.osti.gov/servlets/purl/1351895.
@article{osti_1351895,
title = {Host cells and methods for production of isobutanol},
author = {Anthony, Larry Cameron and He, Hongxian and Huang, Lixuan Lisa and Okeefe, Daniel P. and Kruckeberg, Arthur Leo and Li, Yougen and Maggio-Hall, Lori Ann and McElvain, Jessica and Nelson, Mark J. and Patnaik, Ranjan and Rothman, Steven Cary},
abstractNote = {Provided herein are recombinant yeast host cells and methods for their use for production of isobutanol. Yeast host cells provided comprise an isobutanol biosynthetic pathway and at least one of reduced or eliminated aldehyde dehydrogenase activity, reduced or eliminated acetolactate reductase activity; or a heterologous polynucleotide encoding a polypeptide having ketol-acid reductoisomerase activity.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Aug 23 00:00:00 EDT 2016},
month = {Tue Aug 23 00:00:00 EDT 2016}
}

Patent:

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