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Title: GC-MS metabolomics-based approach for the identification of a potential VOC-biomarker panel in the urine of renal cell carcinoma patients

Journal Article · · Journal of Cellular and Molecular Medicine
DOI:https://doi.org/10.1111/jcmm.13132· OSTI ID:1349777
 [1];  [1];  [1];  [2];  [3];  [4];  [1];  [5];  [6];  [1]
  1. UCIBIO@REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Porto Portugal
  2. Cancer Biology & Epigenetics Group, Portuguese Oncology Institute of Porto (IPOPorto), Porto Portugal, Department of Pathology, Portuguese Oncology Institute of Porto (IPOPorto), Porto Portugal
  3. Cancer Biology & Epigenetics Group, Portuguese Oncology Institute of Porto (IPOPorto), Porto Portugal, Department of Pathology, Portuguese Oncology Institute of Porto (IPOPorto), Porto Portugal, Department of Pathology and Molecular Immunology-Biomedical Sciences Institute (ICBAS), University of Porto, Porto Portugal
  4. Cancer Biology & Epigenetics Group, Portuguese Oncology Institute of Porto (IPOPorto), Porto Portugal, Department of Pathology and Molecular Immunology-Biomedical Sciences Institute (ICBAS), University of Porto, Porto Portugal
  5. CICECO-Instituto de Materiais de Aveiro (CICECO/UA), Departamento de Química, Universidade de Aveiro, Aveiro Portugal
  6. UCIBIO@REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Porto Portugal, UFP Energy, Environment and Health Research Unit (FP-ENAS), Universidade Fernando Pessoa, Porto Portugal

Sponsoring Organization:
USDOE Office of Nuclear Energy (NE), Fuel Cycle Technologies (NE-5)
Grant/Contract Number:
SFRH/BD/80518/2011; SFRH/BDP/109668/2015
OSTI ID:
1349777
Alternate ID(s):
OSTI ID: 1349778
Journal Information:
Journal of Cellular and Molecular Medicine, Journal Name: Journal of Cellular and Molecular Medicine Vol. 21 Journal Issue: 9; ISSN 1582-1838
Publisher:
Wiley-BlackwellCopyright Statement
Country of Publication:
Country unknown/Code not available
Language:
English
Citation Metrics:
Cited by: 57 works
Citation information provided by
Web of Science

References (53)

The analysis of volatile organic compounds biomarkers for lung cancer in exhaled breath, tissues and cell lines journal October 2012
Specific detection of volatile metabolites in urines of normal subjects and patients with diabetes mellitus using computerized mass fragmentography journal January 1975
Impact of Prenatal Disorders on the Metabolic Profile of Second Trimester Amniotic Fluid: A Nuclear Magnetic Resonance Metabonomic Study journal November 2010
Melanoma Volatile Fingerprint with a Gas Sensor Array: In Vivo and In Vitro Study journal September 2009
Sensory Threshold of 1,1,6-Trimethyl-1,2-dihydronaphthalene (TDN) and Concentrations in Young Riesling and Non-Riesling Wines journal March 2012
DHEAS Levels and Mortality in Disabled Older Women: The Women's Health and Aging Study I journal September 2006
Sampling and analysis of metabolomes in biological fluids journal January 2014
Nmr-Based Metabolomics journal January 2002
Renal cell carcinoma journal October 2011
Accuracy of volatile urine biomarkers for the detection and characterization of lung cancer journal December 2015
Second Trimester Maternal Urine for the Diagnosis of Trisomy 21 and Prediction of Poor Pregnancy Outcomes journal May 2013
Volatile organic compounds from feces and their potential for diagnosis of gastrointestinal disease journal June 2007
Identification of Potential Biomarkers for Ovarian Cancer by Urinary Metabolomic Profiling journal December 2012
Analytical Approaches to Metabolomics and Applications to Systems Biology journal September 2010
The scent of disease: volatile organic compounds of the human body related to disease and disorder journal July 2011
Urinary volatile organic compounds as potential biomarkers for renal cell carcinoma journal May 2016
Pathway analysis of kidney cancer using proteomics and metabolic profiling journal November 2006
A comprehensive urinary metabolomic approach for identifying kidney cancer journal April 2007
Cells producing their own nemesis: Understanding methylglyoxal metabolism: Cause and Consequences of Methylglyoxal Metabolism journal October 2014
Solid phase microextraction, mass spectrometry and metabolomic approaches for detection of potential urinary cancer biomarkers—A powerful strategy for breast cancer diagnosis journal January 2012
The role of diabetes mellitus in the aetiology of renal cell cancer journal January 1999
Human Breath Odors and Their Use in Diagnosis journal March 2007
Quantitative metabolomics using NMR journal March 2008
The Human Urine Metabolome journal September 2013
Volatile organic compounds as biomarkers of bladder cancer: Sensitivity and specificity using trained sniffer dogs journal October 2011
Capillary gas chromatographic determination of methylglyoxal from serum of diabetic patients by precolumn derivatization with 1,2-diamonopropane journal September 2008
Smell as a diagnostic marker journal March 1976
Noninvasive analysis of volatile biomarkers in human emanations for health and early disease diagnosis journal June 2013
Investigation of urinary volatile organic metabolites as potential cancer biomarkers by solid-phase microextraction in combination with gas chromatography-mass spectrometry journal November 2011
Volatile organic compounds as new biomarkers for colorectal cancer: a review journal July 2016
Identification of melanoma with a gas sensor array journal May 2008
Excretion and Perception of a Characteristic Odor in Urine after Asparagus Ingestion: a Psychophysical and Genetic Study journal September 2010
Profile of volatile metabolites in urine by gas chromatography-mass spectrometry journal April 1973
Urinary excretion patterns of endogenously produced alcohols in type 1 (IDDM) and type 2 (NIDDM) diabetes mellitus compared with healthy control subjects journal October 1990
Epidemiology and risk factors for kidney cancer journal May 2010
The glyoxalase pathway: the first hundred years… and beyond journal June 2013
Reactive oxygen species in cancer journal January 2010
1,1,6-Trimethyl-1,2-dihydronaphthalene (TDN) formation in wine. 1. Studies on the hydrolysis of 2,6,10,10-tetramethyl-1-oxaspiro[4.5]dec-6-ene-2,8-diol rationalizing the origin of TDN and related C13 norisoprenoids in Riesling wine journal October 1991
Genetically-Based Olfactory Signatures Persist Despite Dietary Variation journal October 2008
Oxidative stress, inflammation, and cancer: How are they linked? journal December 2010
Quantitative measurement of human physiological age by profiling of body fluids and pattern recognition journal June 1991
Landmarks in the diagnosis and treatment of renal cell carcinoma journal August 2014
Analysis of volatile human urinary metabolome by solid-phase microextraction in combination with gas chromatography–mass spectrometry for biomarker discovery: Application in a pilot study to discriminate patients with renal cell carcinoma journal July 2014
Effect size estimation: Methods and examples journal August 2012
Olfactory detection of human bladder cancer by dogs: proof of principle study journal September 2004
Comparison of the Volatile Organic Compounds from Different Biological Specimens for Profiling Potential*: VOC COMPARISONS FOR PROFILING POTENTIAL journal July 2012
The Use of Canines in the Detection of Human Cancers journal January 2008
Urinary Volatile Compounds as Biomarkers for Lung Cancer: A Proof of Principle Study Using Odor Signatures in Mouse Models of Lung Cancer journal January 2010
( E )-1-(2,3,6-Trimethylphenyl)buta-1,3-diene:  A Potent Grape-Derived Odorant in Wine journal December 2003
Olfactory Detection of Prostate Cancer by Dogs Sniffing Urine: A Step Forward in Early Diagnosis journal February 2011
EAU Guidelines on Renal Cell Carcinoma: 2014 Update journal May 2015
Prognostic Impact of the 2009 UICC/AJCC TNM Staging System for Renal Cell Carcinoma with Venous Extension journal January 2011
Volatile Disease Biomarkers in Breath: A Critique journal July 2011

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