Eukaryotic damaged DNA-binding proteins: DNA repair proteins or transcription factors?
- National Institutes of Health, Bethesda, MD (United States)
Recognition and removal of structural defects in the genome, caused by diverse physical and chemical agents, are among the most important cell functions. Proteins that recognize and bind to modified DNA, and thereby initiate damage-induced recovery processes, have been identified in prokaryotic and eukaryotic cells. Damaged DNA-binding (DDB) proteins from prokaryotes are either DNA repair enzymes or noncatalytic subunits of larger DNA repair complexes that participate in excision repair, or in recombinational repair and SOS-mutagenesis. Although the methods employed may not have allowed detection of all eukaryotic DDB proteins and identification of their functions, it appears that during evolution cells have developed a wide array of DDB proteins that can discriminate among the diversity of DNA conformations found in the eukaryotic nucleus, as well as a gene-sharing feature found in DDB proteins that also act as transcription factors.
- Research Organization:
- New York Academy of Sciences, New York, NY (United States)
- OSTI ID:
- 134870
- Report Number(s):
- CONF-9307221-; TRN: 95:007741-0037
- Resource Relation:
- Conference: DNA damage: effects on DNA structure and protein recognition, Burlington, VT (United States), 31 Jul - 4 Aug 1993; Other Information: PBD: 1994; Related Information: Is Part Of DNA damage: Effects on DNA structure and protein recognition; Wallace, S.S.; Van Houten, B.; Kow, Yoke Wah [eds.]; PB: 395 p.
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BASIC STUDIES
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
DNA
DNA REPAIR
MUTATIONS
GENETIC RADIATION EFFECTS
GENETIC EFFECTS
DNA SEQUENCING
GENES
TRANSCRIPTION
GENE RECOMBINATION
PROTEINS
STRUCTURE-ACTIVITY RELATIONSHIPS
NUCLEOTIDES
ANIMAL CELLS
PYRIMIDINE DIMERS
AMINO ACIDS
DNA HYBRIDIZATION
BANDING TECHNIQUES
ULTRAVIOLET RADIATION
XERODERMA PIGMENTOSUM
TRANSCRIPTION FACTORS