Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state

Rossey, Iebe; Gilman, Morgan S.  A.; Kabeche, Stephanie C.; Sedeyn, Koen; Wrapp, Daniel; Kanekiyo, Masaru; Chen, Man; Mas, Vicente; Spitaels, Jan; Melero, José A.; Graham, Barney S.; Schepens, Bert; McLellan, Jason S.; Saelens, Xavier

doi:10.1038/ncomms14158

Title: Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state

Journal Article · Mon Feb 13 00:00:00 EST 2017 · Nature Communications

DOI:https://doi.org/10.1038/ncomms14158· OSTI ID:1347753

Rossey, Iebe; Gilman, Morgan S. A.; Kabeche, Stephanie C.; Sedeyn, Koen; Wrapp, Daniel;

; Chen, Man; Mas, Vicente; Spitaels, Jan; Melero, José A.; Graham, Barney S.; Schepens, Bert; McLellan, Jason S.; Saelens, Xavier

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Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: NIHFOREIGN

OSTI ID:: 1347753

Journal Information:: Nature Communications, Vol. 8, Issue 02, 2017; ISSN 2041-1723

Publisher:: Nature Publishing Group

Country of Publication:: United States

Language:: ENGLISH

References (42)

Cleavage of the human respiratory syncytial virus fusion protein at two distinct sites is required for activation of membrane fusion Gonzalez-Reyes, L.; Ruiz-Arguello, M. B.; Garcia-Barreno, B. Proceedings of the National Academy of Sciences, Vol. 98, Issue 17 https://doi.org/10.1073/pnas.151098198	journal	August 2001
Generation of stable monoclonal antibody–producing B cell receptor–positive human memory B cells by genetic programming Kwakkenbos, Mark J.; Diehl, Sean A.; Yasuda, Etsuko Nature Medicine, Vol. 16, Issue 1 https://doi.org/10.1038/nm.2071	journal	December 2009
Contribution of the Respiratory Syncytial Virus G Glycoprotein and Its Secreted and Membrane-Bound Forms to Virus Replication in Vitro and in Vivo Teng, Michael N.; Whitehead, Stephen S.; Collins, Peter L. Virology, Vol. 289, Issue 2 https://doi.org/10.1006/viro.2001.1138	journal	October 2001
The preclinical pharmacology of the high affinity anti-IL-6R Nanobody® ALX-0061 supports its clinical development in rheumatoid arthritis Van Roy, Maarten; Ververken, Cedric; Beirnaert, Els Arthritis Research & Therapy, Vol. 17, Issue 1 https://doi.org/10.1186/s13075-015-0651-0	journal	May 2015
iMOSFLM : a new graphical interface for diffraction-image processing with MOSFLM Battye, T. Geoff G.; Kontogiannis, Luke; Johnson, Owen Acta Crystallographica Section D Biological Crystallography, Vol. 67, Issue 4 https://doi.org/10.1107/S0907444910048675	journal	March 2011
Respiratory syncytial virus (RSV) SH and G proteins are not essential for viral replication in vitro: Clinical evaluation and molecular characterization of a cold-passaged, attenuated RSV subgroup B mutant Karron, R. A.; Buonagurio, D. A.; Georgiu, A. F. Proceedings of the National Academy of Sciences, Vol. 94, Issue 25 https://doi.org/10.1073/pnas.94.25.13961	journal	December 1997
Blocking Intercellular Adhesion Molecule-1 on Human Epithelial Cells Decreases Respiratory Syncytial Virus Infection Behera, Aruna K.; Matsuse, Hiroto; Kumar, Mukesh Biochemical and Biophysical Research Communications, Vol. 280, Issue 1 https://doi.org/10.1006/bbrc.2000.4093	journal	January 2001
Condensed protocol for competent cell preparation and transformation of the methylotrophic yeast Pichia pastoris Lin-Cereghino, Joan; Wong, William W.; Xiong, See BioTechniques, Vol. 38, Issue 1 https://doi.org/10.2144/05381BM04	journal	January 2005
A stabilized respiratory syncytial virus reverse genetics system amenable to recombination-mediated mutagenesis Hotard, Anne L.; Shaikh, Fyza Y.; Lee, Sujin Virology, Vol. 434, Issue 1 https://doi.org/10.1016/j.virol.2012.09.022	journal	December 2012
Coot model-building tools for molecular graphics Emsley, Paul; Cowtan, Kevin Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12, p. 2126-2132 https://doi.org/10.1107/S0907444904019158	journal	November 2004
Structure of the Extracellular Domain of Matrix Protein 2 of Influenza A Virus in Complex with a Protective Monoclonal Antibody Cho, Ki Joon; Schepens, Bert; Seok, Jong Hyeon Journal of Virology, Vol. 89, Issue 7 https://doi.org/10.1128/JVI.02576-14	journal	January 2015
Motavizumab Treatment of Infants Hospitalized With Respiratory Syncytial Virus Infection Does Not Decrease Viral Load or Severity of Illness Ramilo, Octavio; Lagos, Rosanna; Sáez-Llorens, Xavier The Pediatric Infectious Disease Journal, Vol. 33, Issue 7 https://doi.org/10.1097/INF.0000000000000240	journal	January 2014
Identification of nucleolin as a cellular receptor for human respiratory syncytial virus Tayyari, Farnoosh; Marchant, David; Moraes, Theo J. Nature Medicine, Vol. 17, Issue 9 https://doi.org/10.1038/nm.2444	journal	August 2011
Comparison of llama VH sequences from conventional and heavy chain antibodies Vu, Khoa Bang; Ghahroudi, Mehdi Arbabi; Wyns, Lode Molecular Immunology, Vol. 34, Issue 16-17 https://doi.org/10.1016/S0161-5890(97)00146-6	journal	November 1997
Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus McLellan, J. S.; Chen, M.; Joyce, M. G. Science, Vol. 342, Issue 6158 https://doi.org/10.1126/science.1243283	journal	October 2013
The Fusion Glycoprotein of Human Respiratory Syncytial Virus Facilitates Virus Attachment and Infectivity via an Interaction with Cellular Heparan Sulfate Feldman, S. A.; Audet, S.; Beeler, J. A. Journal of Virology, Vol. 74, Issue 14 https://doi.org/10.1128/JVI.74.14.6442-6447.2000	journal	July 2000
Naturally occurring antibodies devoid of light chains Hamers-Casterman, C.; Atarhouch, T.; Muyldermans, S. Nature, Vol. 363, Issue 6428 https://doi.org/10.1038/363446a0	journal	June 1993
Development of a Humanized Monoclonal Antibody (MEDI‐493) with Potent In Vitro and In Vivo Activity against Respiratory Syncytial Virus Johnson, Syd; Oliver, Cynthia; Prince, Gregory A. The Journal of Infectious Diseases, Vol. 176, Issue 5 https://doi.org/10.1086/514115	journal	November 1997
PHENIX : building new software for automated crystallographic structure determination Adams, Paul D.; Grosse-Kunstleve, Ralf W.; Hung, Li-Wei Acta Crystallographica Section D Biological Crystallography, Vol. 58, Issue 11 https://doi.org/10.1107/S0907444902016657	journal	October 2002
Conservation of G-Protein Epitopes in Respiratory Syncytial Virus (Group A) Despite Broad Genetic Diversity: Is Antibody Selection Involved in Virus Evolution? Trento, Alfonsina; Ábrego, Leyda; Rodriguez-Fernandez, Rosa Journal of Virology, Vol. 89, Issue 15 https://doi.org/10.1128/JVI.00467-15	journal	May 2015
How good are my data and what is the resolution? Evans, Philip R.; Murshudov, Garib N. Acta Crystallographica Section D Biological Crystallography, Vol. 69, Issue 7 https://doi.org/10.1107/S0907444913000061	journal	June 2013
Development of Motavizumab, an Ultra-potent Antibody for the Prevention of Respiratory Syncytial Virus Infection in the Upper and Lower Respiratory Tract Wu, Herren; Pfarr, David S.; Johnson, Syd Journal of Molecular Biology, Vol. 368, Issue 3 https://doi.org/10.1016/j.jmb.2007.02.024	journal	May 2007
Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis Nair, Harish; Nokes, D. James; Gessner, Bradford D. The Lancet, Vol. 375, Issue 9725 https://doi.org/10.1016/S0140-6736(10)60206-1	journal	May 2010
Structure of Respiratory Syncytial Virus Fusion Glycoprotein in the Postfusion Conformation Reveals Preservation of Neutralizing Epitopes McLellan, J. S.; Yang, Y.; Graham, B. S. Journal of Virology, Vol. 85, Issue 15 https://doi.org/10.1128/JVI.00555-11	journal	May 2011
Molecular basis for the preferential cleft recognition by dromedary heavy-chain antibodies De Genst, E.; Silence, K.; Decanniere, K. Proceedings of the National Academy of Sciences, Vol. 103, Issue 12 https://doi.org/10.1073/pnas.0505379103	journal	March 2006
Nanobodies® † †Nanobody is a registered trademark of Ablynx NV. as inhaled biotherapeutics for lung diseases Van Heeke, Gino; Allosery, Koen; De Brabandere, Veronique Pharmacology & Therapeutics, Vol. 169 https://doi.org/10.1016/j.pharmthera.2016.06.012	journal	January 2017
Molecular mechanism of respiratory syncytial virus fusion inhibitors Battles, Michael B.; Langedijk, Johannes P.; Furmanova-Hollenstein, Polina Nature Chemical Biology, Vol. 12, Issue 2 https://doi.org/10.1038/nchembio.1982	journal	December 2015
The Comparative Genomics of Human Respiratory Syncytial Virus Subgroups A and B: Genetic Variability and Molecular Evolutionary Dynamics Tan, L.; Coenjaerts, F. E. J.; Houspie, L. Journal of Virology, Vol. 87, Issue 14 https://doi.org/10.1128/JVI.03278-12	journal	May 2013
Preclinical efficacy and safety of mepolizumab (SB-240563), a humanized monoclonal antibody to IL-5, in cynomolgus monkeys Hart, Timothy K.; Cook, Richard M.; Zia-Amirhosseini, Parnian Journal of Allergy and Clinical Immunology, Vol. 108, Issue 2 https://doi.org/10.1067/mai.2001.116576	journal	August 2001
Characterization of a Prefusion-Specific Antibody That Recognizes a Quaternary, Cleavage-Dependent Epitope on the RSV Fusion Glycoprotein Gilman, Morgan S. A.; Moin, Syed M.; Mas, Vicente PLOS Pathogens, Vol. 11, Issue 7 https://doi.org/10.1371/journal.ppat.1005035	journal	July 2015
Cross-neutralization of four paramyxoviruses by a human monoclonal antibody Corti, Davide; Bianchi, Siro; Vanzetta, Fabrizia Nature, Vol. 501, Issue 7467 https://doi.org/10.1038/nature12442	journal	August 2013
Discovery of an Oral Respiratory Syncytial Virus (RSV) Fusion Inhibitor (GS-5806) and Clinical Proof of Concept in a Human RSV Challenge Study Mackman, Richard L.; Sangi, Michael; Sperandio, David Journal of Medicinal Chemistry, Vol. 58, Issue 4 https://doi.org/10.1021/jm5017768	journal	January 2015
Characterization of the epitope for anti-human respiratory syncytial virus F protein monoclonal antibody 101F using synthetic peptides and genetic approaches Wu, S. -J.; Schmidt, A.; Beil, E. J. Journal of General Virology, Vol. 88, Issue 10 https://doi.org/10.1099/vir.0.82753-0	journal	October 2007
Generation and Characterization of ALX-0171, a Potent Novel Therapeutic Nanobody for the Treatment of Respiratory Syncytial Virus Infection Detalle, Laurent; Stohr, Thomas; Palomo, Concepción Antimicrobial Agents and Chemotherapy, Vol. 60, Issue 1 https://doi.org/10.1128/AAC.01802-15	journal	October 2015
Neutralizing antibodies against the preactive form of respiratory syncytial virus fusion protein offer unique possibilities for clinical intervention Magro, M.; Mas, V.; Chappell, K. Proceedings of the National Academy of Sciences, Vol. 109, Issue 8 https://doi.org/10.1073/pnas.1115941109	journal	February 2012
A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversification in sharks Greenberg, Andrew S.; Avila, David; Hughes, Marianne Nature, Vol. 374, Issue 6518 https://doi.org/10.1038/374168a0	journal	March 1995
Respiratory Syncytial Virus Infection in Elderly and High-Risk Adults Falsey, Ann R.; Hennessey, Patricia A.; Formica, Maria A. New England Journal of Medicine, Vol. 352, Issue 17 https://doi.org/10.1056/NEJMoa043951	journal	April 2005
Nanobodies® Specific for Respiratory Syncytial Virus Fusion Protein Protect Against Infection by Inhibition of Fusion Schepens, Bert; Ibañez, Lorena Itatí; De Baets, Sarah The Journal of Infectious Diseases, Vol. 204, Issue 11 https://doi.org/10.1093/infdis/jir622	journal	October 2011
Prefusion F–specific antibodies determine the magnitude of RSV neutralizing activity in human sera Ngwuta, Joan O.; Chen, Man; Modjarrad, Kayvon Science Translational Medicine, Vol. 7, Issue 309 https://doi.org/10.1126/scitranslmed.aac4241	journal	October 2015
Efficient production of human bivalent and trivalent anti-MUC1 Fab-scFv antibodies in Pichia pastoris Schoonooghe, Steve; Kaigorodov, Vladimir; Zawisza, Monika BMC Biotechnology, Vol. 9, Issue 1 https://doi.org/10.1186/1472-6750-9-70	journal	January 2009
Nanobodies as Versatile Tools to Understand, Diagnose, Visualize and Treat Cancer Van Audenhove, Isabel; Gettemans, Jan EBioMedicine, Vol. 8 https://doi.org/10.1016/j.ebiom.2016.04.028	journal	June 2016
Phaser crystallographic software McCoy, Airlie J.; Grosse-Kunstleve, Ralf W.; Adams, Paul D. Journal of Applied Crystallography, Vol. 40, Issue 4 https://doi.org/10.1107/S0021889807021206	journal	July 2007

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