skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: The structure of a doripenem-bound OXA-51 class D β-lactamase variant with enhanced carbapenemase activity: Structure of OXA-51 I129L with Doripenem Bound

Journal Article · · Protein Science
DOI:https://doi.org/10.1002/pro.3040· OSTI ID:1347020
 [1];  [1];  [1];  [2];  [3];  [1];  [2];  [1]
  1. Department of Chemistry, Grand Valley State University, Allendale Michigan 49401
  2. Department of Cell and Molecular Biology, Grand Valley State University, Allendale Michigan 49401
  3. Life Sciences Collaborative Access Team, Synchrotron Research Center, Northwestern University, Argonne Illinois 60439

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
UNIVERSITYNIH
OSTI ID:
1347020
Journal Information:
Protein Science, Vol. 25, Issue 12; ISSN 0961-8368
Publisher:
The Protein Society
Country of Publication:
United States
Language:
ENGLISH

References (33)

Evolution of Carbapenem-Resistant Acinetobacter baumannii Revealed through Whole-Genome Sequencing and Comparative Genomic Analysis journal December 2014
An OXA-66/OXA-51-Like Carbapenemase and Possibly an Efflux Pump Are Associated with Resistance to Imipenem in Acinetobacter baumannii journal August 2007
blaOXA-51-type β-lactamase genes are ubiquitous and vary within a strain in Acinetobacter baumannii journal August 2006
Class D β-Lactamases: A Reappraisal after Five Decades journal July 2013
First Identification of bla OXA-51-like in Non- baumannii Acinetobacter spp. journal October 2009
The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumannii: Role of ISAba1 in expression of OXA carbapenemase genes journal May 2006
The 1.4 Å Crystal Structure of the Class D β-Lactamase OXA-1 Complexed with Doripenem journal December 2009
Structures of the Class D Carbapenemase OXA-24 from Acinetobacter baumannii in Complex with Doripenem journal March 2011
Antimicrobial Resistance Determinants in Acinetobacter baumannii Isolates Taken from Military Treatment Facilities journal November 2013
MMTSB Tool Set: enhanced sampling and multiscale modeling methods for applications in structural biology journal May 2004
Structural Basis for Carbapenemase Activity of the OXA-23 β-Lactamase from Acinetobacter baumannii journal September 2013
Structural Basis for Enhancement of Carbapenemase Activity in the OXA-51 Family of Class D β-Lactamases journal June 2015
Structural Basis of Activity against Aztreonam and Extended Spectrum Cephalosporins for Two Carbapenem-Hydrolyzing Class D β-Lactamases from Acinetobacter baumannii journal March 2015
Comparison of simple potential functions for simulating liquid water journal July 1983
Extensively Drug-Resistant Acinetobacter baumannii journal June 2009
Crystal Structure of the OXA-48 β-Lactamase Reveals Mechanistic Diversity among Class D Carbapenemases journal May 2009
Structures of the Class D Carbapenemases OXA-23 and OXA-146: Mechanistic Basis of Activity against Carbapenems, Extended-Spectrum Cephalosporins, and Aztreonam journal July 2013
The Rise of Carbapenem-Resistant Acinetobacter baumannii journal January 2013
Outer membrane permeability of Acinetobacter calcoaceticus and its implication in antibiotic resistance journal January 1991
Protein structure prediction on the Web: a case study using the Phyre server journal February 2009
CHARMM: The biomolecular simulation program journal July 2009
OXA  -Lactamases journal April 2014
Calculation of protein extinction coefficients from amino acid sequence data journal November 1989
Eleven novel OXA-51-like enzymes from clinical isolates of Acinetobacter baumannii journal November 2007
Common Clinical Substitutions Enhance the Carbapenemase Activity of OXA-51-Like Class D β-Lactamases from Acinetobacter spp. journal August 2014
Emergence and Distribution of Plasmids Bearing the blaOXA-51-Like Gene with an Upstream ISAba1 in Carbapenem-Resistant Acinetobacter baumannii Isolates in Taiwan journal August 2010
Clinical Variants of the Native Class D β-Lactamase of Acinetobacter baumannii Pose an Emerging Threat through Increased Hydrolytic Activity against Carbapenems journal August 2016
Evolution to carbapenem-hydrolyzing activity in noncarbapenemase class D  -lactamase OXA-10 by rational protein design journal October 2011
Conversion of OXA-66 into OXA-82 in clinical Acinetobacter baumannii isolates and association with altered carbapenem susceptibility journal September 2012
Mutation of the Active Site Carboxy-Lysine (K70) of OXA-1 β-Lactamase Results in a Deacylation-Deficient Enzyme journal July 2009
[20] Processing of X-ray diffraction data collected in oscillation mode book January 1997
OXA-51-like β-lactamases and their association with particular epidemic lineages of Acinetobacter baumannii journal March 2008
Phaser crystallographic software journal July 2007