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Title: Positron emission tomography probe to monitor selected sugar metabolism in vivo

Abstract

The invention disclosed herein discloses selected ribose isomers that are useful as PET probes (e.g. [18F]-2-fluoro-2-deoxy-arabinose). These PET probes are useful, for example, in methods designed to monitor physiological processes including ribose metabolism and/or to selectively observe certain tissue/organs in vivo. The invention disclosed herein further provides methods for making and using such probes.

Inventors:
; ; ; ;
Publication Date:
Research Org.:
The Regents of the University of California, Oakland, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1346982
Patent Number(s):
9,592,309
Application Number:
14/399,701
Assignee:
The Regents of the University of California CHO
DOE Contract Number:
SC0001249
Resource Type:
Patent
Resource Relation:
Patent File Date: 2013 May 09
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; 47 OTHER INSTRUMENTATION

Citation Formats

Witte, Owen, Clark, Peter M., Castillo, Blanca Graciela Flores, Jung, Michael E., and Evdokimov, Nikolai M.. Positron emission tomography probe to monitor selected sugar metabolism in vivo. United States: N. p., 2017. Web.
Witte, Owen, Clark, Peter M., Castillo, Blanca Graciela Flores, Jung, Michael E., & Evdokimov, Nikolai M.. Positron emission tomography probe to monitor selected sugar metabolism in vivo. United States.
Witte, Owen, Clark, Peter M., Castillo, Blanca Graciela Flores, Jung, Michael E., and Evdokimov, Nikolai M.. Tue . "Positron emission tomography probe to monitor selected sugar metabolism in vivo". United States. doi:. https://www.osti.gov/servlets/purl/1346982.
@article{osti_1346982,
title = {Positron emission tomography probe to monitor selected sugar metabolism in vivo},
author = {Witte, Owen and Clark, Peter M. and Castillo, Blanca Graciela Flores and Jung, Michael E. and Evdokimov, Nikolai M.},
abstractNote = {The invention disclosed herein discloses selected ribose isomers that are useful as PET probes (e.g. [18F]-2-fluoro-2-deoxy-arabinose). These PET probes are useful, for example, in methods designed to monitor physiological processes including ribose metabolism and/or to selectively observe certain tissue/organs in vivo. The invention disclosed herein further provides methods for making and using such probes.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Mar 14 00:00:00 EDT 2017},
month = {Tue Mar 14 00:00:00 EDT 2017}
}

Patent:

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  • Compounds for use as PET probes and methods for synthesizing and using these, comprising [.sup.18F]D-FAC and other cytosine and adenosine analogs.
  • Based upon data obtained with our arterio-venous technique for the determination of cerebral metabolism in humans in vivo we have proposed a method for the determination of cerebral regional intermediary glucose metabolism in humans in vivo using specifically labeled /sup 11/C-glucose and positron emission transverse tomography (PETT). In it we would give the subject successive intravenous injections of (3,4-/sup 11/C) glucose, (2,5-/sup 11/C) glucose and (1-/sup 11/C) glucose. There would be a 30 min period of continuous PETT measurements following each injection and a 2 hr interval after the first and second injections. The data would be used with suitablemore » equations and algorithms to estimate for each specific region of the subject's brain the dynamics of the Embden-Meyerhof-Parnas (EMP) and the tricarboxylic acid cycle (TCA) metabolic pathways and the incorporation of glucose carbons into lactate, and the extent of dilution of glucose carbons into lactate, and the extent of dilution of glucose carbons in traversing the TCA with their subsequent incorporation into other carbon pools of the brain (ie, glutamate, glutamine, GABA, alanine). Using /sup 14/C as a model for /sup 11/C and autoradiographs made with rat brain slices, we have produced an animal model to demonstrate the feasibility of our proposed method. The resulting autoradiographs have provided evidence of the validity of the predictions made from our arterio-venous data. The model was employed to show the selective reductions in the rates of incorporation of specific carbon atoms of glucose into regions of the rat brain and evidence of altered metabolic pathways following a single electroconvulsive shock (ECS) and after a series of nine ECS.« less
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