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Title: Synthesis and use of 2-[ 18F]fluoromalondialdehyde, an accessible synthon for bioconjugation

Abstract

We proposed methods for the synthesis and purification of 2-[ 18F]fluoromalondialdehyde, which will be a readily accessible synthon for bioconjugation. Our achievements in these areas will specifically address a stated goal of the DOE providing a transformational technology for macromolecule radiolabeling. Accomplishment of our aims will serve both DOE mission-related research as well as nuclear medicine research supported by the NIH and industry. At the heart of our proposal is the aim to “improve synthetic methodology for rapidly and efficiently incorporating radionuclides into a wide range of organic compounds.”

Authors:
 [1]
  1. Massachusetts General Hospital, Boston, MA (United States)
Publication Date:
Research Org.:
Massachusetts General Hospital, Boston, MA (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)
OSTI Identifier:
1346940
Report Number(s):
DOE-MGH-0011947
DOE Contract Number:  
SC0011947
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Hooker, Jacob M. Synthesis and use of 2-[18F]fluoromalondialdehyde, an accessible synthon for bioconjugation. United States: N. p., 2017. Web. doi:10.2172/1346940.
Hooker, Jacob M. Synthesis and use of 2-[18F]fluoromalondialdehyde, an accessible synthon for bioconjugation. United States. doi:10.2172/1346940.
Hooker, Jacob M. Thu . "Synthesis and use of 2-[18F]fluoromalondialdehyde, an accessible synthon for bioconjugation". United States. doi:10.2172/1346940. https://www.osti.gov/servlets/purl/1346940.
@article{osti_1346940,
title = {Synthesis and use of 2-[18F]fluoromalondialdehyde, an accessible synthon for bioconjugation},
author = {Hooker, Jacob M.},
abstractNote = {We proposed methods for the synthesis and purification of 2-[18F]fluoromalondialdehyde, which will be a readily accessible synthon for bioconjugation. Our achievements in these areas will specifically address a stated goal of the DOE providing a transformational technology for macromolecule radiolabeling. Accomplishment of our aims will serve both DOE mission-related research as well as nuclear medicine research supported by the NIH and industry. At the heart of our proposal is the aim to “improve synthetic methodology for rapidly and efficiently incorporating radionuclides into a wide range of organic compounds.”},
doi = {10.2172/1346940},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Thu Mar 16 00:00:00 EDT 2017},
month = {Thu Mar 16 00:00:00 EDT 2017}
}

Technical Report:

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