Linkage disequilibrium between polymorphisms at the 5{prime} untranslated region and intron 5 (Dde I) of the antithrombin III (ATIII) gene in the Chinese

Journal Article · Thu Sep 01 00:00:00 EDT 1994 · American Journal of Human Genetics

OSTI ID:134669

Tay, J S.H.; Liu, Y; Low, P S ^[1]

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1. National Univ. of Sinagapore (Singapore); and others

A length polymorphism at the 5{prime} untranslated region of exon 1 and an RFLP (Dde I) in intron 5 (nt 160) of the ATIII gene were amplified by polymerase chain reaction with primers of published sequences. DNA fragments were size-fractionated by agarose gel electrophoresis (3% NuSieve and 1% Seakem GTG) and photographed over a UV transilluminator. A strong linkage disequilibrium was observed between these two polymorphisms of the ATIII gene in the Chinese ({chi}{sup 2} = 63.7; {triangle} 0.42, P < 0.001). The estimated frequencies of the three haplotypes were found to be 0.37 for SD+, 0.40 for LD+ and 0.23 for LD-.

• OSTI ID: 134669
• Report Number(s): CONF-941009-; ISSN 0002-9297; TRN: 95:005313-1406
• Journal Information: American Journal of Human Genetics, Vol. 55, Issue Suppl.3; Conference: 44. annual meeting of the American Society of Human Genetics, Montreal (Canada), 18-22 Oct 1994; Other Information: PBD: Sep 1994
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
THROMBIN
GENES
GENE MUTATIONS
MUTATION FREQUENCY
DETECTION
CHINA
HUMAN POPULATIONS
POLYMERASE CHAIN REACTION
EXONS
ELECTROPHORESIS
STATISTICS
INTRONS
RFLPS
NUCLEOTIDES
DNA SEQUENCING