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Title: Orthogonal Cas9 proteins for RNA-guided gene regulation and editing

Abstract

Methods of modulating expression of a target nucleic acid in a cell are provided including use of multiple orthogonal Cas9 proteins to simultaneously and independently regulate corresponding genes or simultaneously and independently edit corresponding genes.

Inventors:
; ;
Publication Date:
Research Org.:
President and Fellows of Harvard College, Cambridge, MA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1346066
Patent Number(s):
9,587,252
Application Number:
14/674,895
Assignee:
President and Fellows of Harvard College CHO
DOE Contract Number:  
FG02-02ER63445
Resource Type:
Patent
Resource Relation:
Patent File Date: 2015 Mar 31
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Church, George M., Esvelt, Kevin, and Mali, Prashant. Orthogonal Cas9 proteins for RNA-guided gene regulation and editing. United States: N. p., 2017. Web.
Church, George M., Esvelt, Kevin, & Mali, Prashant. Orthogonal Cas9 proteins for RNA-guided gene regulation and editing. United States.
Church, George M., Esvelt, Kevin, and Mali, Prashant. Tue . "Orthogonal Cas9 proteins for RNA-guided gene regulation and editing". United States. doi:. https://www.osti.gov/servlets/purl/1346066.
@article{osti_1346066,
title = {Orthogonal Cas9 proteins for RNA-guided gene regulation and editing},
author = {Church, George M. and Esvelt, Kevin and Mali, Prashant},
abstractNote = {Methods of modulating expression of a target nucleic acid in a cell are provided including use of multiple orthogonal Cas9 proteins to simultaneously and independently regulate corresponding genes or simultaneously and independently edit corresponding genes.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Mar 07 00:00:00 EST 2017},
month = {Tue Mar 07 00:00:00 EST 2017}
}

Patent:

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