Interactions of 1D- and 2D-layered inorganic nanoparticles with fibroblasts and human mesenchymal stem cells

Rashkow, Jason Thomas; Talukdar, Yahfi; Lalwani, Gaurav; Sitharaman, Balaji

doi:10.2217/nnm.15.35

Title: Interactions of 1D- and 2D-layered inorganic nanoparticles with fibroblasts and human mesenchymal stem cells

Journal Article · Mon Jun 01 00:00:00 EDT 2015 · Nanomedicine

DOI:https://doi.org/10.2217/nnm.15.35· OSTI ID:1345589

Rashkow, Jason Thomas ^[1]; Talukdar, Yahfi ^[1]; Lalwani, Gaurav ^[1]; Sitharaman, Balaji ^[1]

Stony Brook Univ., Stony Brook, NY (United States). Dept. of Biomedical Engineering

Here, this study investigates the effects of tungsten disulfide nanotubes (WSNTs) and molybdenum disulfide nanoplatelets (MSNPs) on fibroblasts (NIH-3T3) and mesenchymal stem cells (MSCs) to determine safe dosages for potential biomedical applications. Cytotoxicity of MSNPs and WSNTs (5–300 μg/ml) on NIH-3T3 and MSCs was assessed at 6, 12 or 24 h. MSC differentiation to adipocytes and osteoblasts was assessed following treatment for 24 h. Only NIH-3T3 cells treated with MSNPs showed dose or time dependent increase in cytotoxicity. Differentiation markers of MSCs in treated groups were unaffected compared with untreated controls. In conclusion, MSNPs and WSNTs at concentrations less than 50 μg/ml are potentially safe for treatment of fibroblasts or MSCs for up to 24 h.

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Research Organization:: Stony Brook Univ., NY (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-98CH10886; 1DP2OD007394-01

OSTI ID:: 1345589

Journal Information:: Nanomedicine, Vol. 10, Issue 11; ISSN 1743-5889

Publisher:: Future MedicineCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 21 works

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Title: Interactions of 1D- and 2D-layered inorganic nanoparticles with fibroblasts and human mesenchymal stem cells

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