Production of isotopes using high power proton beams

Nolen, Jr., Jerry A.; Gomes, Itacil C.

Production of isotopes using high power proton beams

Patent · 30 November 2015

OSTI ID:1345367

Nolen, Jr., Jerry A.; Gomes, Itacil C.

The invention provides for a method for producing isotopes using a beam of particles from an accelerator, whereby the beam is maintained at between about 70 to 2000 MeV; and contacting a thorium-containing target with the particles. The medically important isotope .sup.225Ac is produced via the nuclear reaction (p,2p6n), whereby an energetic proton causes the ejection of 2 protons and 6 neutrons from a .sup.232Th target nucleus. Another medically important isotope .sup.213Bi is then available as a decay product. The production of highly purified .sup.211At is also provided.

Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-06CH11357

Assignee:: UCHICAGO ARGONNE, LLC (Chicago, IL)

Patent Number(s):: 9,202,602

Application Number:: 13/025,079

OSTI ID:: 1345367

Country of Publication:: United States

Language:: English

References (6)

Targeted α-particle radiotherapy with ²¹¹At-labeled monoclonal antibodies Zalutsky, Michael R.; Reardon, David A.; Pozzi, Oscar R. Nuclear Medicine and Biology, Vol. 34, Issue 7, p. 779-785 https://doi.org/10.1016/j.nucmedbio.2007.03.007	journal	October 2007
Production of Ac-225 from Th-229 for Targeted α Therapy Apostolidis, C.; Molinet, R.; Rasmussen, G. Analytical Chemistry, Vol. 77, Issue 19 https://doi.org/10.1021/ac0580114	journal	October 2005
Cancer Therapy with Alpha-Emitters Labeled Peptides Dadachova, Ekaterina Seminars in Nuclear Medicine, Vol. 40, Issue 3 https://doi.org/10.1053/j.semnuclmed.2010.01.002	journal	May 2010
Production of ²²⁵Ac and ²²³Ra by irradiation of Th with accelerated protons Zhuikov, B. L.; Kalmykov, S. N.; Ermolaev, S. V. Radiochemistry, Vol. 53, Issue 1, p. 73-80 https://doi.org/10.1134/S1066362211010103	journal	February 2011
Spallation of Uranium and Thorium Nuclei with Bev-Energy Protons Pate, B. D.; Poskanzer, A. M. Physical Review, Vol. 123, Issue 2 https://doi.org/10.1103/PhysRev.123.647	journal	July 1961
Targeted Killing of Virally Infected Cells by Radiolabeled Antibodies to Viral Proteins Dadachova, Ekaterina; Patel, Mahesh C.; Toussi, Sima PLoS Medicine, Vol. 3, Issue 11 https://doi.org/10.1371/journal.pmed.0030427	journal	November 2006

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