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Title: Red fluorescent zinc oxide nanoparticle: A novel platform for cancer targeting

Abstract

Multifunctional zinc oxide (ZnO) nanoparticles (NPs) with well-integrated multimodality imaging capacities have generated increasing research interest in the past decade. However, limited progress has been made in developing ZnO NP-based multimodality tumor-imaging agents. In this paper, we developed novel red fluorescent ZnO NPs and described the successful conjugation of 64Cu ( t 1/2 = 12.7 h) and TRC105, a chimeric monoclonal antibody against CD105, to these ZnO NPs via well-developed surface engineering procedures. The produced dual-modality ZnO NPs were readily applicable for positron emission tomography (PET) imaging and fluorescence imaging of the tumor vasculature. Their pharmacokinetics and tumor-targeting efficacy/specificity in mice bearing murine breast 4T1 tumor were thoroughly investigated. In conclusion, ZnO NPs with dual-modality imaging properties can serve as an attractive candidate for future cancer theranostics.

Authors:
 [1];  [1];  [1];  [1];  [2];  [1];  [3];  [1];  [1];  [4]
  1. Univ. of Wisconsin, Madison, WI (United States)
  2. Univ. of Wisconsin, Madison, WI (United States); American Univ. of Beirut, Beirut (Lebanon)
  3. TRACON Pharmaceuticals, San Diego, CA (United States)
  4. Univ. of Wisconsin, Madison, WI (United States); Univ. of Wisconsin Carbone Cancer Center, Madison, WI (United States)
Publication Date:
Research Org.:
Univ. of Wisconsin, Madison, WI (United States)
Sponsoring Org.:
USDOE Office of Science (SC); USDOE Advanced Research Projects Agency - Energy (ARPA-E); National Institutes of Health (NIH); US Air Force Office of Scientific Research (AFOSR); American Cancer Society
OSTI Identifier:
1345171
Alternate Identifier(s):
OSTI ID: 1441140
Grant/Contract Number:  
SC0008384; SC0008391; 1R01CA169365; P30CA014520; W81XWH-11-1-0644; W81XWH- 11-1-0648; 125246-RSG-13-099-01-CCE
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
ACS Applied Materials and Interfaces
Additional Journal Information:
Journal Volume: 7; Journal Issue: 5; Journal ID: ISSN 1944-8244
Publisher:
American Chemical Society (ACS)
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 60 APPLIED LIFE SCIENCES; angiogenesis; CD105; drug delivery; imaging; positron emission tomography; zinc oxide; 77 NANOSCIENCE AND NANOTECHNOLOGY

Citation Formats

Hong, Hao, Wang, Fei, Zhang, Yin, Graves, Stephen A., Eddine, Savo Bou Zein, Yang, Yunan, Theuer, Charles P., Nickles, Robert J., Wang, Xudong, and Cai, Weibo. Red fluorescent zinc oxide nanoparticle: A novel platform for cancer targeting. United States: N. p., 2015. Web. doi:10.1021/am508440j.
Hong, Hao, Wang, Fei, Zhang, Yin, Graves, Stephen A., Eddine, Savo Bou Zein, Yang, Yunan, Theuer, Charles P., Nickles, Robert J., Wang, Xudong, & Cai, Weibo. Red fluorescent zinc oxide nanoparticle: A novel platform for cancer targeting. United States. doi:10.1021/am508440j.
Hong, Hao, Wang, Fei, Zhang, Yin, Graves, Stephen A., Eddine, Savo Bou Zein, Yang, Yunan, Theuer, Charles P., Nickles, Robert J., Wang, Xudong, and Cai, Weibo. Wed . "Red fluorescent zinc oxide nanoparticle: A novel platform for cancer targeting". United States. doi:10.1021/am508440j. https://www.osti.gov/servlets/purl/1345171.
@article{osti_1345171,
title = {Red fluorescent zinc oxide nanoparticle: A novel platform for cancer targeting},
author = {Hong, Hao and Wang, Fei and Zhang, Yin and Graves, Stephen A. and Eddine, Savo Bou Zein and Yang, Yunan and Theuer, Charles P. and Nickles, Robert J. and Wang, Xudong and Cai, Weibo},
abstractNote = {Multifunctional zinc oxide (ZnO) nanoparticles (NPs) with well-integrated multimodality imaging capacities have generated increasing research interest in the past decade. However, limited progress has been made in developing ZnO NP-based multimodality tumor-imaging agents. In this paper, we developed novel red fluorescent ZnO NPs and described the successful conjugation of 64Cu (t1/2 = 12.7 h) and TRC105, a chimeric monoclonal antibody against CD105, to these ZnO NPs via well-developed surface engineering procedures. The produced dual-modality ZnO NPs were readily applicable for positron emission tomography (PET) imaging and fluorescence imaging of the tumor vasculature. Their pharmacokinetics and tumor-targeting efficacy/specificity in mice bearing murine breast 4T1 tumor were thoroughly investigated. In conclusion, ZnO NPs with dual-modality imaging properties can serve as an attractive candidate for future cancer theranostics.},
doi = {10.1021/am508440j},
journal = {ACS Applied Materials and Interfaces},
number = 5,
volume = 7,
place = {United States},
year = {Wed Jan 21 00:00:00 EST 2015},
month = {Wed Jan 21 00:00:00 EST 2015}
}

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Cited by: 15 works
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