skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Microbiome-wide association studies link dynamic microbial consortia to disease

Abstract

Rapid advances in DNA sequencing, metabolomics, proteomics and computation dramatically increase accessibility of microbiome studies and identify links between the microbiome and disease. Microbial time-series and multiple molecular perspectives enable Microbiome-Wide Association Studies (MWAS), analogous to Genome-Wide Association Studies (GWAS). Rapid research advances point towards actionable results, although approved clinical tests based on MWAS are still in the future. Appreciating the complexity of interactions between diet, chemistry, health and the microbiome, and determining the frequency of observations needed to capture and integrate this dynamic interface, is paramount for addressing the need for personalized and precision microbiome-based diagnostics and therapies.

Authors:
; ; ; ; ; ; ; ;
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1342303
Report Number(s):
PNNL-SA-118611
Journal ID: ISSN 0028-0836
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Journal Article
Resource Relation:
Journal Name: Nature (London); Journal Volume: 535; Journal Issue: 7610
Country of Publication:
United States
Language:
English
Subject:
MWAS; Microbiome

Citation Formats

Gilbert, Jack A., Quinn, Robert A., Debelius, Justine, Xu, Zhenjiang Z., Morton, James, Garg, Neha, Jansson, Janet K., Dorrestein, Pieter C., and Knight, Rob. Microbiome-wide association studies link dynamic microbial consortia to disease. United States: N. p., 2016. Web. doi:10.1038/nature18850.
Gilbert, Jack A., Quinn, Robert A., Debelius, Justine, Xu, Zhenjiang Z., Morton, James, Garg, Neha, Jansson, Janet K., Dorrestein, Pieter C., & Knight, Rob. Microbiome-wide association studies link dynamic microbial consortia to disease. United States. doi:10.1038/nature18850.
Gilbert, Jack A., Quinn, Robert A., Debelius, Justine, Xu, Zhenjiang Z., Morton, James, Garg, Neha, Jansson, Janet K., Dorrestein, Pieter C., and Knight, Rob. Wed . "Microbiome-wide association studies link dynamic microbial consortia to disease". United States. doi:10.1038/nature18850.
@article{osti_1342303,
title = {Microbiome-wide association studies link dynamic microbial consortia to disease},
author = {Gilbert, Jack A. and Quinn, Robert A. and Debelius, Justine and Xu, Zhenjiang Z. and Morton, James and Garg, Neha and Jansson, Janet K. and Dorrestein, Pieter C. and Knight, Rob},
abstractNote = {Rapid advances in DNA sequencing, metabolomics, proteomics and computation dramatically increase accessibility of microbiome studies and identify links between the microbiome and disease. Microbial time-series and multiple molecular perspectives enable Microbiome-Wide Association Studies (MWAS), analogous to Genome-Wide Association Studies (GWAS). Rapid research advances point towards actionable results, although approved clinical tests based on MWAS are still in the future. Appreciating the complexity of interactions between diet, chemistry, health and the microbiome, and determining the frequency of observations needed to capture and integrate this dynamic interface, is paramount for addressing the need for personalized and precision microbiome-based diagnostics and therapies.},
doi = {10.1038/nature18850},
journal = {Nature (London)},
number = 7610,
volume = 535,
place = {United States},
year = {Wed Jul 06 00:00:00 EDT 2016},
month = {Wed Jul 06 00:00:00 EDT 2016}
}