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Title: Influence of early life exposure, host genetics and diet on the mouse gut microbiome and metabolome

Abstract

Although the gut microbiome plays important roles in host physiology, health and disease1, we lack understanding of the complex interplay between host genetics and early life environment on the microbial and metabolic composition of the gut.We used the genetically diverse Collaborative Cross mouse system2 to discover that early life history impacts themicrobiome composition, whereas dietary changes have only a moderate effect. By contrast, the gut metabolome was shaped mostly by diet, with specific non-dietary metabolites explained by microbial metabolism. Quantitative trait analysis identified mouse genetic trait loci (QTL) that impact the abundances of specific microbes. Human orthologues of genes in the mouse QTL are implicated in gastrointestinal cancer. Additionally, genes located in mouse QTL for Lactobacillales abundance are implicated in arthritis, rheumatic disease and diabetes. Furthermore, Lactobacillales abundance was predictive of higher host T-helper cell counts, suggesting an important link between Lactobacillales and host adaptive immunity.

Authors:
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Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1342294
Report Number(s):
PNNL-SA-118063
Journal ID: ISSN 2058-5276; 453040086
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Journal Article
Journal Name:
Nature Microbiology
Additional Journal Information:
Journal Volume: 2; Journal ID: ISSN 2058-5276
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; Collaborative Cross; microbiome; Metabolome

Citation Formats

Snijders, Antoine M., Langley, Sasha A., Kim, Young-Mo, Brislawn, Colin J., Noecker, Cecilia, Zink, Erika M., Fansler, Sarah J., Casey, Cameron P., Miller, Darla R., Huang, Yurong, Karpen, Gary H., Celniker, Susan E., Brown, James B., Borenstein, Elhanan, Jansson, Janet K., Metz, Thomas O., and Mao, Jian-Hua. Influence of early life exposure, host genetics and diet on the mouse gut microbiome and metabolome. United States: N. p., 2016. Web. doi:10.1038/nmicrobiol.2016.221.
Snijders, Antoine M., Langley, Sasha A., Kim, Young-Mo, Brislawn, Colin J., Noecker, Cecilia, Zink, Erika M., Fansler, Sarah J., Casey, Cameron P., Miller, Darla R., Huang, Yurong, Karpen, Gary H., Celniker, Susan E., Brown, James B., Borenstein, Elhanan, Jansson, Janet K., Metz, Thomas O., & Mao, Jian-Hua. Influence of early life exposure, host genetics and diet on the mouse gut microbiome and metabolome. United States. doi:10.1038/nmicrobiol.2016.221.
Snijders, Antoine M., Langley, Sasha A., Kim, Young-Mo, Brislawn, Colin J., Noecker, Cecilia, Zink, Erika M., Fansler, Sarah J., Casey, Cameron P., Miller, Darla R., Huang, Yurong, Karpen, Gary H., Celniker, Susan E., Brown, James B., Borenstein, Elhanan, Jansson, Janet K., Metz, Thomas O., and Mao, Jian-Hua. Mon . "Influence of early life exposure, host genetics and diet on the mouse gut microbiome and metabolome". United States. doi:10.1038/nmicrobiol.2016.221.
@article{osti_1342294,
title = {Influence of early life exposure, host genetics and diet on the mouse gut microbiome and metabolome},
author = {Snijders, Antoine M. and Langley, Sasha A. and Kim, Young-Mo and Brislawn, Colin J. and Noecker, Cecilia and Zink, Erika M. and Fansler, Sarah J. and Casey, Cameron P. and Miller, Darla R. and Huang, Yurong and Karpen, Gary H. and Celniker, Susan E. and Brown, James B. and Borenstein, Elhanan and Jansson, Janet K. and Metz, Thomas O. and Mao, Jian-Hua},
abstractNote = {Although the gut microbiome plays important roles in host physiology, health and disease1, we lack understanding of the complex interplay between host genetics and early life environment on the microbial and metabolic composition of the gut.We used the genetically diverse Collaborative Cross mouse system2 to discover that early life history impacts themicrobiome composition, whereas dietary changes have only a moderate effect. By contrast, the gut metabolome was shaped mostly by diet, with specific non-dietary metabolites explained by microbial metabolism. Quantitative trait analysis identified mouse genetic trait loci (QTL) that impact the abundances of specific microbes. Human orthologues of genes in the mouse QTL are implicated in gastrointestinal cancer. Additionally, genes located in mouse QTL for Lactobacillales abundance are implicated in arthritis, rheumatic disease and diabetes. Furthermore, Lactobacillales abundance was predictive of higher host T-helper cell counts, suggesting an important link between Lactobacillales and host adaptive immunity.},
doi = {10.1038/nmicrobiol.2016.221},
journal = {Nature Microbiology},
issn = {2058-5276},
number = ,
volume = 2,
place = {United States},
year = {2016},
month = {11}
}