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Title: Iron ion and iron hydroxide adsorption to charge-neutral phosphatidylcholine templates

Abstract

Surface-sensitive X-ray scattering and spectroscopy techniques reveal significant adsorption of iron ions and iron-hydroxide (Fe(III)) complexes to a charge-neutral zwitterionic template of phosphatidylcholine (PC). The PC template is formed by a Langmuir monolayer of dipalmitoyl-PC (DPPC) that is spread on the surface of 2 to 40 μM FeCl 3 solutions at physiological levels of KCl (100 mM). At 40 μM of Fe(III) as many as ~3 iron atoms are associated with each PC group. Grazing incidence X-ray diffraction measurements indicate a significant disruption in the in-plane ordering of DPPC molecules upon iron adsorption. The binding of iron-hydroxide complexes to a neutral PC surface is yet another example of nonelectrostatic, presumably covalent bonding to a charge-neutral organic template. Furthermore, the strong binding and the disruption of in-plane lipid structure has biological implications on the integrity of PC-derived lipid membranes, including those based on sphingomyelin.

Authors:
 [1];  [2];  [2];  [1];  [2];  [2]
  1. Ames Lab., Ames, IA (United States)
  2. Ames Lab. and Iowa State Univ., Ames, IA (United States)
Publication Date:
Research Org.:
Ames Laboratory (AMES), Ames, IA (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
OSTI Identifier:
1337691
Report Number(s):
IS-J-9113
Journal ID: ISSN 0743-7463
Grant/Contract Number:  
AC02-07CH11358
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Langmuir
Additional Journal Information:
Journal Volume: 32; Journal Issue: 30; Journal ID: ISSN 0743-7463
Publisher:
American Chemical Society
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Wang, Wenjie, Zhang, Honghu, Feng, Shuren, San Emeterio, Josue, Mallapragada, Surya, and Vaknin, David. Iron ion and iron hydroxide adsorption to charge-neutral phosphatidylcholine templates. United States: N. p., 2016. Web. doi:10.1021/acs.langmuir.6b01851.
Wang, Wenjie, Zhang, Honghu, Feng, Shuren, San Emeterio, Josue, Mallapragada, Surya, & Vaknin, David. Iron ion and iron hydroxide adsorption to charge-neutral phosphatidylcholine templates. United States. doi:10.1021/acs.langmuir.6b01851.
Wang, Wenjie, Zhang, Honghu, Feng, Shuren, San Emeterio, Josue, Mallapragada, Surya, and Vaknin, David. Wed . "Iron ion and iron hydroxide adsorption to charge-neutral phosphatidylcholine templates". United States. doi:10.1021/acs.langmuir.6b01851. https://www.osti.gov/servlets/purl/1337691.
@article{osti_1337691,
title = {Iron ion and iron hydroxide adsorption to charge-neutral phosphatidylcholine templates},
author = {Wang, Wenjie and Zhang, Honghu and Feng, Shuren and San Emeterio, Josue and Mallapragada, Surya and Vaknin, David},
abstractNote = {Surface-sensitive X-ray scattering and spectroscopy techniques reveal significant adsorption of iron ions and iron-hydroxide (Fe(III)) complexes to a charge-neutral zwitterionic template of phosphatidylcholine (PC). The PC template is formed by a Langmuir monolayer of dipalmitoyl-PC (DPPC) that is spread on the surface of 2 to 40 μM FeCl3 solutions at physiological levels of KCl (100 mM). At 40 μM of Fe(III) as many as ~3 iron atoms are associated with each PC group. Grazing incidence X-ray diffraction measurements indicate a significant disruption in the in-plane ordering of DPPC molecules upon iron adsorption. The binding of iron-hydroxide complexes to a neutral PC surface is yet another example of nonelectrostatic, presumably covalent bonding to a charge-neutral organic template. Furthermore, the strong binding and the disruption of in-plane lipid structure has biological implications on the integrity of PC-derived lipid membranes, including those based on sphingomyelin.},
doi = {10.1021/acs.langmuir.6b01851},
journal = {Langmuir},
issn = {0743-7463},
number = 30,
volume = 32,
place = {United States},
year = {2016},
month = {7}
}

Journal Article:
Free Publicly Available Full Text
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Cited by: 2 works
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