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Title: IC Post-Doctoral Fellowship Abstract and Bio.

Abstract

Whole cell biosensors (WCBs) utilize an organism’s natural ability to sense and respond to the environment. Through implementation of two different protein engineering methods, I seek to develop a WCB for the detection of important chemical signatures in the environment. I will reengineer the ligand binding profile of proteins known to alter transcription of genes, and I will engineer signal transduction in proteins already known to bind relevant compounds. In both cases, detection of compounds of interest will lead to the production of a measurable fluorescent signal within the organism. These approaches will provide the groundwork for the development of novel chemical sensing technologies that provide a cheap and efficient alternative to traditional methods for detection of compounds.

Authors:
 [1]
  1. Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Publication Date:
Research Org.:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1333518
Report Number(s):
SAND-2016-11823R
649373
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Lacey, Randy. IC Post-Doctoral Fellowship Abstract and Bio.. United States: N. p., 2016. Web. doi:10.2172/1333518.
Lacey, Randy. IC Post-Doctoral Fellowship Abstract and Bio.. United States. doi:10.2172/1333518.
Lacey, Randy. Tue . "IC Post-Doctoral Fellowship Abstract and Bio.". United States. doi:10.2172/1333518. https://www.osti.gov/servlets/purl/1333518.
@article{osti_1333518,
title = {IC Post-Doctoral Fellowship Abstract and Bio.},
author = {Lacey, Randy},
abstractNote = {Whole cell biosensors (WCBs) utilize an organism’s natural ability to sense and respond to the environment. Through implementation of two different protein engineering methods, I seek to develop a WCB for the detection of important chemical signatures in the environment. I will reengineer the ligand binding profile of proteins known to alter transcription of genes, and I will engineer signal transduction in proteins already known to bind relevant compounds. In both cases, detection of compounds of interest will lead to the production of a measurable fluorescent signal within the organism. These approaches will provide the groundwork for the development of novel chemical sensing technologies that provide a cheap and efficient alternative to traditional methods for detection of compounds.},
doi = {10.2172/1333518},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2016},
month = {11}
}

Technical Report:

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