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Title: Transcription activator-like effectors

Patent ·
OSTI ID:1333298
; ; ;

Provided herein are compositions, kits and methods useful in the construction of designer transcription activator-like effector (dTALE) polypeptides.

Research Organization:
Harvard Univ., Cambridge, MA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
FG02-02ER63445
Assignee:
President and Fellows of Harvard College (Cambridge, MA)
Patent Number(s):
9,499,592
Application Number:
13/353,662
OSTI ID:
1333298
Resource Relation:
Patent File Date: 2012 Jan 19
Country of Publication:
United States
Language:
English

References (12)

A One Pot, One Step, Precision Cloning Method with High Throughput Capability journal November 2008
The Xanthomonas Type III Effector Protein AvrBs3 Modulates Plant Gene Expression and Induces Cell Hypertrophy in the Susceptible Host journal July 2002
Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription journal January 2011
Xanthomonas AvrBs3 Family-Type III Effectors: Discovery and Function journal July 2010
R gene expression induced by a type-III effector triggers disease resistance in rice journal June 2005
TAL effectors: finding plant genes for disease and defense journal August 2010
The repeat domain of the type III effector protein PthA shows a TPR-like structure and undergoes conformational changes upon DNA interaction
  • Murakami, Mário Tyago; Sforça, Mauricio Luis; Neves, Jorge Luiz
  • Proteins: Structure, Function, and Bioinformatics, Vol. 78, Issue 16 https://doi.org/10.1002/prot.22846
journal September 2010
Gene-for-gene-mediated recognition of nuclear-targeted AvrBs3-like bacterial effector proteins journal February 2006
Golden Gate Shuffling: A One-Pot DNA Shuffling Method Based on Type IIs Restriction Enzymes journal May 2009
Scalable gene synthesis by selective amplification of DNA pools from high-fidelity microchips journal November 2010
A Bacterial Effector Acts as a Plant Transcription Factor and Induces a Cell Size Regulator journal October 2007
Plant Pathogen Recognition Mediated by Promoter Activation of the Pepper Bs3 Resistance Gene journal October 2007

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