5-Fluoroimidazo[4,5- b ]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors

Journal Article · Mon Apr 11 00:00:00 EDT 2016 · ACS Infectious Diseases

DOI:https://doi.org/10.1021/acsinfecdis.6b00036· OSTI ID:1331717

Zhang, Zhongsheng ^[1]; Koh, Cho Yeow ^[1]; Ranade, Ranae M. ^[2]; Shibata, Sayaka ^[1]; Gillespie, J. Robert ^[2]; Hulverson, Matthew A. ^[2]; Huang, Wenlin ^[1]; Nguyen, Jasmine ^[1]; Pendem, Nagendar ^[3]; Gelb, Michael H. ^[3]; Verlinde, Christophe L. M. J. ^[1]; Hol, Wim G. J. ^[1]; Buckner, Frederick S. ^[2]; Fan, Erkang ^[1]

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1. Department of Biochemistry, University of Washington, 1705 N.E. Pacific Street, Seattle, Washington 98195, United States
2. Department of Medicine, Division of Allergy and Infectious Diseases, and the Center for Emerging and Re-emerging Infectious Diseases (CERID), University of Washington, 750 Republican Street, Seattle, Washington 98109, United States
3. Department of Chemistry, Bagley Hall, University of Washington, Seattle, Washington 98195, United States

• Sponsoring Organization: USDOE Office of Science (SC), Basic Energy Sciences (BES)
• Grant/Contract Number: AC02-76SF00515
• OSTI ID: 1331717
• Journal Information: ACS Infectious Diseases, Journal Name: ACS Infectious Diseases Vol. 2 Journal Issue: 6; ISSN 2373-8227
• Publisher: American Chemical Society
• Country of Publication: United States
• Language: English