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Two-dimensional fourier transform spectrometer

Patent ·
OSTI ID:1330327

The present invention relates to a system and methods for acquiring two-dimensional Fourier transform (2D FT) spectra. Overlap of a collinear pulse pair and probe induce a molecular response which is collected by spectral dispersion of the signal modulated probe beam. Simultaneous collection of the molecular response, pulse timing and characteristics permit real time phasing and rapid acquisition of spectra. Full spectra are acquired as a function of pulse pair timings and numerically transformed to achieve the full frequency-frequency spectrum. This method demonstrates the ability to acquire information on molecular dynamics, couplings and structure in a simple apparatus. Multi-dimensional methods can be used for diagnostic and analytical measurements in the biological, biomedical, and chemical fields.

Research Organization:
Massachusetts Institute of Technology, Cambridge, MA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
FG02-99ER14988
Assignee:
Massachusetts Institute of Technology (Cambridge, MA)
Patent Number(s):
9,476,768
Application Number:
13/955,158
OSTI ID:
1330327
Country of Publication:
United States
Language:
English

References (5)

Coherent 2D IR Spectroscopy:  Molecular Structure and Dynamics in Solution journal July 2003
Automated 2D IR spectroscopy using a mid-IR pulse shaper and application of this technology to the human islet amyloid polypeptide journal May 2007
Inherently phase-stable coherent two-dimensional spectroscopy using only conventional optics journal January 2008
T WO -D IMENSIONAL F EMTOSECOND S PECTROSCOPY journal October 2003
Signal enhancement and background cancellation in collinear two-dimensional spectroscopies journal January 2008