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Title: Recent Activities at Los Alamos National Laboratory Supporting Domestic Production of 99Mo

Authors:
 [1]
  1. Los Alamos National Laboratory
Publication Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE National Nuclear Security Administration (NNSA), Office of Defense Nuclear Nonproliferation (NA-20)
OSTI Identifier:
1329643
Report Number(s):
LA-UR-16-26942
DOE Contract Number:
AC52-06NA25396
Resource Type:
Conference
Resource Relation:
Conference: Mo-99 Topical Meeting ; 2016-09-12 - 2016-09-12 ; St Louis, Missouri, United States
Country of Publication:
United States
Language:
English

Citation Formats

Dale, Gregory E. Recent Activities at Los Alamos National Laboratory Supporting Domestic Production of 99Mo. United States: N. p., 2016. Web.
Dale, Gregory E. Recent Activities at Los Alamos National Laboratory Supporting Domestic Production of 99Mo. United States.
Dale, Gregory E. 2016. "Recent Activities at Los Alamos National Laboratory Supporting Domestic Production of 99Mo". United States. doi:. https://www.osti.gov/servlets/purl/1329643.
@article{osti_1329643,
title = {Recent Activities at Los Alamos National Laboratory Supporting Domestic Production of 99Mo},
author = {Dale, Gregory E.},
abstractNote = {},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = 2016,
month = 9
}

Conference:
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  • Prior to 1989 {sup 99}Mo was produced in the US by a single supplier, Cintichem Inc., Tuxedo, NY. Because of problems associated with operating its facility, in 1989 Cintichem elected to decommission the facility rather than incur the costs for repair. The demise of the {sup 99}Mo capability at Cintichem left the US totally reliant upon a single foreign source, Nordion International, located in Ottawa Canada. In 1992 the DOE purchased the Cintichem {sup 99}Mo Production Process and Drug Master File (DMF). In 1994 the DOE funded Sandia National Laboratories (SNL) to produce {sup 99}Mo. Although Cintichem produced {sup 99}Momore » and {sup 99m}Tc generators for many years, there was no requirement for process validation which is now required by the Food and Drug Administration (FDA). In addition to the validation requirement, the requirements for current Good manufacturing Practices were codified into law. The purpose of this paper is to describe the process validation being conducted at SNL for the qualification of SNL as a supplier of {sup 99}Mo to US pharmaceutical companies.« less
  • Summary of LANL FY12 Activities are: (1) Preparation, performance, and data analysis for the FY12 accelerator tests at ANL - (a) LANL designed and installed a closed-loop helium target cooling system at ANL for the FY12 accelerator tests, (b) Thermal test was performed on March 27, (c) 24 h production test to follow the accelerator upgrade at ANL; (2) Local target shielding design and OTR/IR recommendations - (a) Target dose rate and activation products were calculated with MCNPX, (b) {sup 206}Pb({gamma},2n){sup 204m}Pb vs {sup 204g}Pb branching ratio unpublished, will measure using the LANL microtron, (c) OTR system nearing final configuration,more » (d) IR prototype system demonstrated during the recent thermal test at ANL; (3) Target housing lifetime estimation - Target housing material specifications and design to be finalized following the thermal test, lifetime not believed to be an issue; and (4) Target cooling system reliability - Long duration system characterizations will begin following the thermal test.« less
  • An update will be given of activities at Los Alamos National Laboratory aimed at developing optical model potentials for applied calculations. Recent work on a coupled-channels potential for neutron reactions on {sup 241,243}Am and spherical neutron potential updates for {sup 56}Fe and {sup 59}Co will be presented, together with examples of their application in nuclear reaction calculations with the GNASH code system. New potentials utilized in evaluations at Livermore for {sup 12}C, {sup 14}N and {sup 16}O are described and additional potentials from earlier analyses at Los Alamos of Ti, V, and Ni data are made available for possible inclusionmore » in the Reference Input Parameter Library (RIPL) for nuclear model calculations of nuclear data. Specific activities directed at development of the optical potential segment of the RIPL will be summarized.« less