Optimizing Blue Persistent Luminescence in (Sr 1-δ Ba δ ) 2 MgSi 2 O 7: Eu 2+ ,Dy 3+ via Solid Solution for Use in Point-of-Care Diagnostics
Abstract
Inorganic persistent luminescent phosphors are an excellent class of optical reporters for enabling sensitive point-of-care diagnostics, particularly with smartphone-based biosensing devices in testing formats such as the lateral flow assay (LFA). Here, the development of persistent phosphors for this application is focused on the solid solution (Sr1-δBaδ)2MgSi2O7:Eu2+,Dy3+ (δ = 0, 0.125, 0.25, 0.375), which is prepared using a high-temperature solid-state reaction as confirmed by synchrotron X-ray powder diffraction. The substitution of barium for strontium enables control over the Eu2+ 5d-orbital crystal field splitting (CFS) as a tool for tuning the emission wavelength while maintaining luminescence lifetimes >9 min across the composition range. Thermoluminescence measurements of the solid solution provide evidence that trap states contribute to the persistent lifetimes with the trap depths also remaining constant as a function of composition. Time-gated luminescence images of these compounds are captured on a smartphone arranged in a layout to mimic a point-of-care test and demonstrate the viability of using these materials as optical reporters. Moreover, comparing the blue-emitting (Sr0.625Ba0.375)2MgSi2O7:Eu2+,Dy3+ and the green-emitting SrAl2O4:Eu2+,Dy3+ in a single LFA-type format shows these two compounds can be detected and resolved simultaneously, thereby permitting the development of a multiplexed LFA.
- Authors:
-
- Univ. of Houston, TX (United States). Dept. of Chemistry
- Luminostics Inc., Houston, TX (United States); Univ. of Houston, TX (United States). Dept. of Chemical and Biomolecular Engineering
- Publication Date:
- Research Org.:
- Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1329406
- Resource Type:
- Journal Article
- Journal Name:
- ACS Applied Materials and Interfaces
- Additional Journal Information:
- Journal Volume: 8; Journal Issue: 40; Journal ID: ISSN 1944-8244
- Publisher:
- American Chemical Society
- Country of Publication:
- United States
- Language:
- ENGLISH
- Subject:
- 36 MATERIALS SCIENCE
Citation Formats
Finley, Erin, Cobb, Angelica, Duke, Anna, Paterson, Andrew, and Brgoch, Jakoah. Optimizing Blue Persistent Luminescence in (Sr 1-δ Ba δ ) 2 MgSi 2 O 7: Eu 2+ ,Dy 3+ via Solid Solution for Use in Point-of-Care Diagnostics. United States: N. p., 2016.
Web. doi:10.1021/acsami.6b10303.
Finley, Erin, Cobb, Angelica, Duke, Anna, Paterson, Andrew, & Brgoch, Jakoah. Optimizing Blue Persistent Luminescence in (Sr 1-δ Ba δ ) 2 MgSi 2 O 7: Eu 2+ ,Dy 3+ via Solid Solution for Use in Point-of-Care Diagnostics. United States. https://doi.org/10.1021/acsami.6b10303
Finley, Erin, Cobb, Angelica, Duke, Anna, Paterson, Andrew, and Brgoch, Jakoah. 2016.
"Optimizing Blue Persistent Luminescence in (Sr 1-δ Ba δ ) 2 MgSi 2 O 7: Eu 2+ ,Dy 3+ via Solid Solution for Use in Point-of-Care Diagnostics". United States. https://doi.org/10.1021/acsami.6b10303.
@article{osti_1329406,
title = {Optimizing Blue Persistent Luminescence in (Sr 1-δ Ba δ ) 2 MgSi 2 O 7: Eu 2+ ,Dy 3+ via Solid Solution for Use in Point-of-Care Diagnostics},
author = {Finley, Erin and Cobb, Angelica and Duke, Anna and Paterson, Andrew and Brgoch, Jakoah},
abstractNote = {Inorganic persistent luminescent phosphors are an excellent class of optical reporters for enabling sensitive point-of-care diagnostics, particularly with smartphone-based biosensing devices in testing formats such as the lateral flow assay (LFA). Here, the development of persistent phosphors for this application is focused on the solid solution (Sr1-δBaδ)2MgSi2O7:Eu2+,Dy3+ (δ = 0, 0.125, 0.25, 0.375), which is prepared using a high-temperature solid-state reaction as confirmed by synchrotron X-ray powder diffraction. The substitution of barium for strontium enables control over the Eu2+ 5d-orbital crystal field splitting (CFS) as a tool for tuning the emission wavelength while maintaining luminescence lifetimes >9 min across the composition range. Thermoluminescence measurements of the solid solution provide evidence that trap states contribute to the persistent lifetimes with the trap depths also remaining constant as a function of composition. Time-gated luminescence images of these compounds are captured on a smartphone arranged in a layout to mimic a point-of-care test and demonstrate the viability of using these materials as optical reporters. Moreover, comparing the blue-emitting (Sr0.625Ba0.375)2MgSi2O7:Eu2+,Dy3+ and the green-emitting SrAl2O4:Eu2+,Dy3+ in a single LFA-type format shows these two compounds can be detected and resolved simultaneously, thereby permitting the development of a multiplexed LFA.},
doi = {10.1021/acsami.6b10303},
url = {https://www.osti.gov/biblio/1329406},
journal = {ACS Applied Materials and Interfaces},
issn = {1944-8244},
number = 40,
volume = 8,
place = {United States},
year = {Fri Nov 04 00:00:00 EDT 2016},
month = {Fri Nov 04 00:00:00 EDT 2016}
}