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Title: Research Projects for Interrogations of Biological Systems: Training for the Development of Novel Radiotracers

Abstract

This grant was situated at the University of Missouri to train Ph.D. scientists in radiochemistry and synthetic chemistry in conjunction with Faculty from the Interdisciplinary Plant Group, Division of Biological Sciences, the MU Research Reactor Center, Molecular Biology and the Radiopharmaceutical Sciences Institute. This project was collaborative with Brookhaven National Laboratory (Richard Ferrieri, PI). Projects for the Ph.D. candidates included novel probe development for peptides, nucleosides, small molecules or radiometals, the direct use of radiometals as probes, or nuclear techniques for analysis. The projects for the postdoctoral fellow involved synthetic chemistry for the preparation of precursors for novel tracers that will be radiolabeled with 18F or other appropriate radionuclides. The skill sets of our team members allowed us to prepare probes with positron or single photon emitters, as well as ones that are dual-labeled (fluorescent and radiolabeled). We focused our technical advances to those that will be broadly applicable to any research field.

Authors:
 [1];  [1];  [1]
  1. Univ. of Missouri, Columbia, MO (United States)
Publication Date:
Research Org.:
Univ. of Missouri, Columbia, MO (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)
OSTI Identifier:
1327823
Report Number(s):
DOE-MU-2040-1
TRN: US1700325
DOE Contract Number:
SC0002040
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; FLUORINE 18; RADIOCHEMISTRY; TRACER TECHNIQUES; FLUORESCENCE; TRAINING; NUCLEOSIDES; PEPTIDES; PROBES; RADIOPHARMACEUTICALS; MOLECULAR BIOLOGY; PLANTS; PRECURSOR; radiotracer uptake; radiotracer transport; plant imaging; radiometals; fluorine-18 labeled sucrose

Citation Formats

Jurisson, Silvia S., Lever, Susan Z., and Robertson, J. David. Research Projects for Interrogations of Biological Systems: Training for the Development of Novel Radiotracers. United States: N. p., 2016. Web. doi:10.2172/1327823.
Jurisson, Silvia S., Lever, Susan Z., & Robertson, J. David. Research Projects for Interrogations of Biological Systems: Training for the Development of Novel Radiotracers. United States. doi:10.2172/1327823.
Jurisson, Silvia S., Lever, Susan Z., and Robertson, J. David. Tue . "Research Projects for Interrogations of Biological Systems: Training for the Development of Novel Radiotracers". United States. doi:10.2172/1327823. https://www.osti.gov/servlets/purl/1327823.
@article{osti_1327823,
title = {Research Projects for Interrogations of Biological Systems: Training for the Development of Novel Radiotracers},
author = {Jurisson, Silvia S. and Lever, Susan Z. and Robertson, J. David},
abstractNote = {This grant was situated at the University of Missouri to train Ph.D. scientists in radiochemistry and synthetic chemistry in conjunction with Faculty from the Interdisciplinary Plant Group, Division of Biological Sciences, the MU Research Reactor Center, Molecular Biology and the Radiopharmaceutical Sciences Institute. This project was collaborative with Brookhaven National Laboratory (Richard Ferrieri, PI). Projects for the Ph.D. candidates included novel probe development for peptides, nucleosides, small molecules or radiometals, the direct use of radiometals as probes, or nuclear techniques for analysis. The projects for the postdoctoral fellow involved synthetic chemistry for the preparation of precursors for novel tracers that will be radiolabeled with 18F or other appropriate radionuclides. The skill sets of our team members allowed us to prepare probes with positron or single photon emitters, as well as ones that are dual-labeled (fluorescent and radiolabeled). We focused our technical advances to those that will be broadly applicable to any research field.},
doi = {10.2172/1327823},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Oct 04 00:00:00 EDT 2016},
month = {Tue Oct 04 00:00:00 EDT 2016}
}

Technical Report:

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