.sup.100Mo compounds as accelerator targets for production of .sup.99mTc

Richards, Vernal; Lapi, Suzanne

Title: .sup.100Mo compounds as accelerator targets for production of .sup.99mTc

Patent · Tue Sep 20 00:00:00 EDT 2016

OSTI ID:1325736

Richards, Vernal; Lapi, Suzanne

Methods of synthesizing .sup.100Mo.sub.2C and .sup.99mTcO.sub.4.sup.- are disclosed. Methods of .sup.100Mo.sub.2C generation involve thermally carburizing .sup.100MoO.sub.3. Methods of .sup.99mTcO.sub.4 generation involve proton bombardment of .sup.100Mo.sub.2C in a cyclotron. Yields of .sup.99mTcO.sub.4 can be increased by sintering .sup.100Mo.sub.2C prior to bombardment. The methods also include recycling of .sup.100Mo.sub.2C to form .sup.100MoO.sub.3. SPECT images obtained using .sup.99mTcO.sub.4 generated by the disclosed methods are also presented.

View Patent

Cite

Export

Save

Research Organization:: Washington University, Saint Louis, MO (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: SC0006435

Assignee:: Washington University (Saint Louis, MO)

Patent Number(s):: 9,449,726

Application Number:: 14/293,599

OSTI ID:: 1325736

Resource Relation:: Patent File Date: 2014 Jun 02

Country of Publication:: United States

Language:: English

References (21)

Technetium-99m generators Evans, John V.; Matthews, Ralph W. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4280053 US Patent Document 4,280,053	patent	July 1981
Radionuclide generator system and method for its preparation and use Vanderheyden, Jean-Luc; Su, Fu-Min https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4990787 US Patent Document 4,990,787	patent	February 1991
Process for the preparation of rhenium-188 and technetium-99m generators Ehrhardt, Gary J.; Wolfangel, Robert G.; Deutsch, Edward A. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5382388 US Patent Document 5,382,388	patent	January 1995
Method for the production of .sup.99m Tc compositions from .sup.99 Mo-containing materials Bennett, Ralph G.; Christian, Jerry D.; Grover, S. Blaine https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5802439 US Patent Document 5,802,439	patent	September 1998
System for the control, verification and recording of the performance of a radioisotope generator's operations Casale, Guillermo Arturo; Nicolini, Jorge Osvaldo; Kock, Elvira Calvo https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7737415 US Patent Document 7,737,415	patent	June 2010
Medical radioisotopes and methods for producing the same Schenter, Robert E.; Wester, Dennis W.; Hollenberg, Glenn W. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8126104 US Patent Document 8,126,104	patent	February 2012
Clinical studies with spleen-specific radiolabeled agents Armas, Renato R. Seminars in Nuclear Medicine, Vol. 15, Issue 3, p. 260-275 https://doi.org/10.1016/S0001-2998(85)80004-0	journal	July 1985
Evolution of Tc-99m in diagnostic radiopharmaceuticals Banerjee, Sharmila; Ambikalmajan Pillai, Maroor Raghavan; Ramamoorthy, Natesan Seminars in Nuclear Medicine, Vol. 31, Issue 4 https://doi.org/10.1053/snuc.2001.26205	journal	October 2001
A Monte Carlo computer program for the transport of energetic ions in amorphous targets Biersack, J. P.; Haggmark, L. G. Nuclear Instruments and Methods, Vol. 174, Issue 1-2, p. 257-269 https://doi.org/10.1016/0029-554X(80)90440-1	journal	August 1980
Advances in the production, processing and microPET image quality of technetium-94m Bigott, Heather M.; Laforest, Richard; Liu, Xiaodong Nuclear Medicine and Biology, Vol. 33, Issue 7, p. 923-933 https://doi.org/10.1016/j.nucmedbio.2006.07.001	journal	October 2006
Decomposition of molybdate–hexamethylenetetramine complex: One single source route for different catalytic materials Chouzier, Sandra; Czeri, Tivadar; Roy-Auberger, Magalie Journal of Solid State Chemistry, Vol. 184, Issue 10, p. 2668-2677 https://doi.org/10.1016/j.jssc.2011.08.005	journal	October 2011
⁹⁹Mo/^99mTc separation: An assessment of technology options Dash, Ashutosh; Knapp, F. F. (Russ); Pillai, M. R. A. Nuclear Medicine and Biology, Vol. 40, Issue 2, p. 167-176 https://doi.org/10.1016/j.nucmedbio.2012.10.005	journal	February 2013
Unparalleled Contribution of Technetium-99m to Medicine Over 5 Decades Eckelman, William C. JACC: Cardiovascular Imaging, Vol. 2, Issue 3, p. 364-368 https://doi.org/10.1016/j.jcmg.2008.12.013	journal	March 2009
Cyclotron production of ^99mTc: Experimental measurement of the ¹⁰⁰Mo(p,x)⁹⁹Mo, ^99mTc and ^99gTc excitation functions from 8 to 18 MeV Gagnon, Katherine; Bénard, François; Kovacs, Michael Nuclear Medicine and Biology, Vol. 38, Issue 6, p. 907-916 https://doi.org/10.1016/j.nucmedbio.2011.02.010	journal	August 2011
Cyclotron production of ^99mTc: Recycling of enriched ¹⁰⁰Mo metal targets Gagnon, K.; Wilson, J. S.; Holt, C. M. B. Applied Radiation and Isotopes, Vol. 70, Issue 8, p. 1685-1690 https://doi.org/10.1016/j.apradiso.2012.04.016	journal	August 2012
The structural and dynamical properties of Al clusters adsorbed on Ni surface Wang, Y. X.; Pan, Z. Y.; Ho, Y. K. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 180, Issue 1-4, p. 251-256 https://doi.org/10.1016/S0168-583X(01)00425-6	journal	June 2001
Cyclotron production of NCA ^99mTc and ⁹⁹Mo. An alternative non-reactor supply source of instant ^99mTc and ⁹⁹Mo→^99mTc generators Lagunas-Solar, Manuel C.; Kiefer, Phil M.; Carvacho, Omar F. International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 42, Issue 7, p. 643-657 https://doi.org/10.1016/0883-2889(91)90035-Y	journal	January 1991
Solid state metathesis: synthesis of metal carbides from metal oxides Nartowski, Artur M.; Parkin, Ivan P.; Mackenzie, Maureen Journal of Materials Chemistry, Vol. 11, Issue 12, p. 3116-3119 https://doi.org/10.1039/B105352N	journal	September 2001
Sustained Availability of 99mTc: Possible Paths Forward Pillai, M. R. A.; Dash, A.; Knapp, F. F. Journal of Nuclear Medicine, Vol. 54, Issue 2 https://doi.org/10.2967/jnumed.112.110338	journal	December 2012
Evaluation of proton induced reactions on ¹⁰⁰Mo: New cross sections for production of ^{99 m}Tc and ⁹⁹Mo Takács, S.; Szűcs, Z.; Tárkányi, F. Journal of Radioanalytical and Nuclear Chemistry, Vol. 257, Issue 1, p. 195-201 https://doi.org/10.1023/A:1024790520036	journal	January 2003
Synthesis of Bulk and Supported Molybdenum Carbide by a Single-Step Thermal Carburization Method Wang, Hua-Min; Wang, Xiao-Hui; Zhang, Ming-Hui Chemistry of Materials, Vol. 19, Issue 7 https://doi.org/10.1021/cm0615471	journal	April 2007

Similar Records

The Recovery of Medical Isotope ¹⁸⁸W from Irradiated W Metal Target - A New Approach

Technical Report · Wed Feb 01 00:00:00 EST 2023 · OSTI ID:1325736

Du, Miting

Scale-up of high specific activity ^186gRe production using graphite-encased thick ¹⁸⁶W targets and demonstration of an efficient target recycling process

Journal Article · Fri Aug 18 00:00:00 EDT 2017 · Radiochimica Acta · OSTI ID:1325736

Balkin, Ethan R.; Gagnon, Katherine; Dorman, Eric; +11 more

Recovery of Mo for Accelerator Production of Mo-99 Using (y,n) Reaction on Mo-100

Technical Report · Mon Sep 30 00:00:00 EDT 2013 · OSTI ID:1325736

Tkac, Peter; Vandegrift, George F.; Nunn, Stephen D.; +1 more

Related Subjects

36 MATERIALS SCIENCE
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Title: .sup.100Mo compounds as accelerator targets for production of .sup.99mTc

Citation Formats

References (21)

Similar Records

Related Subjects