Micro-/mesoporous carbons for controlled release of antipyrine and indomethacin

Saha, Dipendu; Moken, Tara; Chen, Jihua; Hensley, Dale K.; Delaney, Kristen; Hunt, Marcus A.; Nelson, Karl; Spurri, Amada; Benham, Lauren; Brice, Robin; Azoro, Martina

doi:10.1039/C5RA00251F

Title: Micro-/mesoporous carbons for controlled release of antipyrine and indomethacin

Journal Article · Tue Feb 24 00:00:00 EST 2015 · RSC Advances

DOI:https://doi.org/10.1039/C5RA00251F· OSTI ID:1325496

Saha, Dipendu ^[1]; Moken, Tara ^[1]; Chen, Jihua ^[2]; Hensley, Dale K. ^[2]; Delaney, Kristen ^[3]; Hunt, Marcus A. ^[3]; Nelson, Karl ^[1]; Spurri, Amada ^[1]; Benham, Lauren ^[1]; Brice, Robin ^[3]; Azoro, Martina ^[3]

Widener Univ., Chester, PA (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Fayetteville State Univ., Fayetteville, NC (United States)

Here, we have demonstrated the potential of meso- and microporous carbons in controlled release applications and targeted oral drug delivery. We have employed two mesoporous and two microporous carbons for the sustained release of one water-soluble drug (antipyrine) and one water-insoluble drug (indomethacin), using these as models to examine the controlled release characteristics. The micro-/mesoporous carbons were characterized as having a BET surface area of 372–2251 m² g^–1 and pore volume 0.63–1.03 cm³ g^–1. The toxicity studies with E. coli bacterial cells did not reveal significant toxicity, which is in accordance with our previous studies on human cells with similar materials. Mucin adsorption tests with type III pork mucin demonstrated 20–30% mucin adsorption by the carbon samples and higher mucin adsorption could be attributed to higher surface area and more oxygen functionalities. Antipyrine and indomethacin loading was 6–78% in these micro-/mesoporous carbons. The signatures in thermogravimetric studies revealed the presence of drug molecules within the porous moieties of the carbon. The partial shifting of the decomposition peak of the drug adsorbed within the carbon pores was caused by the confinement of drug molecules within the narrow pore space of the carbon. The release profiles of both drugs were examined in simulated gastric fluid (pH = 1.2) and in three other release media with respective pH values of 4.5, 6.8 and 7.4, along with varying residence times to simulate the physiological conditions of the stomach, duodenum, small intestine and colon, respectively. All the release profiles manifested diffusion controlled sustained release that corroborates the effective role of micro-/mesoporous carbons as potential drug carriers.

View Accepted Manuscript (DOE)

Cite

Export

Save

Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Sciences (CNMS)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1325496

Journal Information:: RSC Advances, Vol. 5, Issue 30; ISSN 2046-2069

Publisher:: Royal Society of ChemistryCopyright Statement

Country of Publication:: United States

Language:: English

Citation Metrics:

Cited by: 11 works

Citation information provided by
Web of Science

References (21)

Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention Singh, B. Journal of Controlled Release, Vol. 63, Issue 3 https://doi.org/10.1016/S0168-3659(99)00204-7	journal	February 2000
Application of organogels as oral controlled release formulations of hydrophilic drugs Iwanaga, Kazunori; Kawai, Mineo; Miyazaki, Makoto International Journal of Pharmaceutics, Vol. 436, Issue 1-2 https://doi.org/10.1016/j.ijpharm.2012.06.041	journal	October 2012
Biocompatibility of Soft-Templated Mesoporous Carbons Gencoglu, Maria F.; Spurri, Amanda; Franko, Mitchell ACS Applied Materials & Interfaces, Vol. 6, Issue 17 https://doi.org/10.1021/am503076u	journal	August 2014
Sustainable Mesoporous Carbons as Storage and Controlled-Delivery Media for Functional Molecules Saha, Dipendu; Payzant, E. Andrew; Kumbhar, Amar S. ACS Applied Materials & Interfaces, Vol. 5, Issue 12 https://doi.org/10.1021/am401661f	journal	June 2013
Toxicological Impact Studies Based on Escherichia coli Bacteria in Ultrafine ZnO Nanoparticles Colloidal Medium Brayner, Roberta; Ferrari-Iliou, Roselyne; Brivois, Nicolas Nano Letters, Vol. 6, Issue 4 https://doi.org/10.1021/nl052326h	journal	March 2006
Mesoporous silicon microparticles for oral drug delivery: Loading and release of five model drugs Salonen, J.; Laitinen, L.; Kaukonen, A. M. Journal of Controlled Release, Vol. 108, Issue 2-3 https://doi.org/10.1016/j.jconrel.2005.08.017	journal	November 2005
Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers Slowing, I.; Vivero-Escoto, J.; Wu, C. Advanced Drug Delivery Reviews, Vol. 60, Issue 11, p. 1278-1288 https://doi.org/10.1016/j.addr.2008.03.012	journal	August 2008
Improved oral bioavailability of alendronate via the mucoadhesive liposomal delivery system Han, Hyo-Kyung; Shin, Hyun-Jae; Ha, Dong Hoon European Journal of Pharmaceutical Sciences, Vol. 46, Issue 5 https://doi.org/10.1016/j.ejps.2012.04.002	journal	August 2012
Mesoporous Silica Nanoparticles for Drug Delivery and Biosensing Applications Slowing, I. I.; Trewyn, B. G.; Giri, S. Advanced Functional Materials, Vol. 17, Issue 8 https://doi.org/10.1002/adfm.200601191	journal	April 2007
Degradable Polymer Microspheres for Controlled Drug Delivery Edlund, U.; Albertsson, A. -C. Degradable Aliphatic Polyesters https://doi.org/10.1007/3-540-45734-8_3	book	January 2007
Novel synthesis of Fe-containing mesoporous carbons and their release of ibuprofen Wang, Xiufang; Liu, Ping; Tian, Yong Microporous and Mesoporous Materials, Vol. 145, Issue 1-3 https://doi.org/10.1016/j.micromeso.2011.04.033	journal	November 2011
Hydrophilic mesoporous carbon nanoparticles as carriers for sustained release of hydrophobic anti-cancer drugs Gu, Jinlou; Su, Shasha; Li, Yongsheng Chem. Commun., Vol. 47, Issue 7 https://doi.org/10.1039/C0CC04598E	journal	January 2011
Soft-templated mesoporous carbons as potential materials for oral drug delivery Saha, Dipendu; Warren, Kaitlyn E.; Naskar, Amit K. Carbon, Vol. 71 https://doi.org/10.1016/j.carbon.2014.01.005	journal	May 2014
Functionalized mesoporous silica materials for controlled drug delivery Yang, Piaoping; Gai, Shili; Lin, Jun Chemical Society Reviews, Vol. 41, Issue 9 https://doi.org/10.1039/c2cs15308d	journal	January 2012
Development of new drug delivery system based on ordered mesoporous carbons: characterisation and cytocompatibility studies Karavasili, Christina; Amanatiadou, Elsa P.; Sygellou, Lambrini Journal of Materials Chemistry B, Vol. 1, Issue 25 https://doi.org/10.1039/c3tb20304b	journal	January 2013
Uniform mesoporous carbon as a carrier for poorly water soluble drug and its cytotoxicity study Zhao, Peng; Wang, Lihong; Sun, Changshan European Journal of Pharmaceutics and Biopharmaceutics, Vol. 80, Issue 3 https://doi.org/10.1016/j.ejpb.2011.12.002	journal	April 2012
Controlled release of antipyrine from mesoporous carbons Saha, Dipendu; Warren, Kaitlyn E.; Naskar, Amit K. Microporous and Mesoporous Materials, Vol. 196 https://doi.org/10.1016/j.micromeso.2014.05.024	journal	September 2014
Mesoporous Materials for Drug Delivery Vallet-Regí, María; Balas, Francisco; Arcos, Daniel Angewandte Chemie International Edition, Vol. 46, Issue 40 https://doi.org/10.1002/anie.200604488	journal	October 2007
Slow release kinetics of mitoxantrone from ordered mesoporous carbon films Labiano, Alpha; Dai, Mingzhi; Taylor, David Microporous and Mesoporous Materials, Vol. 160 https://doi.org/10.1016/j.micromeso.2012.05.003	journal	September 2012
Silica Particles: A Novel Drug-Delivery System Barbé, C.; Bartlett, J.; Kong, L. Advanced Materials, Vol. 16, Issue 21 https://doi.org/10.1002/adma.200400771	journal	November 2004
pH-Controlled Delivery of Doxorubicin to Cancer Cells, Based on Small Mesoporous Carbon Nanospheres Zhu, Jie; Liao, Lei; Bian, Xiaojun Small, Vol. 8, Issue 17 https://doi.org/10.1002/smll.201200217	journal	June 2012

Similar Records

Controlled release of alendronate from nitrogen-doped mesoporous carbon

Journal Article · Wed Apr 13 00:00:00 EDT 2016 · Microporous and Mesoporous Materials · OSTI ID:1325496

Saha, Dipendu; Spurri, Amanda; Chen, Jihua; +1 more

Soft-Template-Synthesized Mesoporous Carbon for Oral Drug Delivery

Journal Article · Wed Jan 01 00:00:00 EST 2014 · Carbon · OSTI ID:1325496

Saha, Dipendu; Warren, Kaitlyn E; Naskar, Amit K

Hierarchical Metal–Organic Framework Hybrids: Perturbation-Assisted Nanofusion Synthesis

Journal Article · Fri Dec 04 00:00:00 EST 2015 · Accounts of Chemical Research · OSTI ID:1325496

Yue, Yanfeng; Fulvio, Pasquale F.; Dai, Sheng

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
59 BASIC BIOLOGICAL SCIENCES

Title: Micro-/mesoporous carbons for controlled release of antipyrine and indomethacin

Citation Formats

References (21)

Similar Records

Related Subjects