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Title: Dose-rate controlled energy dispersive x-ray spectroscopic mapping of the metallic components in a biohybrid nanosystem

Abstract

In this work, we showcase that through precise control of the electron dose rate, state-of-the-art large solid angle energy dispersive X-ray spectroscopy (EDS) mapping in aberration-corrected scanning transmission electron microscope (STEM) is capable of faithful and unambiguous chemical characterization of the Pt and Pd distribution in a peptide-mediated nanosystem. This low-dose-rate recording scheme adds another dimension of flexibility to the design of elemental mapping experiments, and holds significant potential for extending its application to a wide variety of beam sensitive hybrid nanostructures.

Authors:
; ; ; ; ; ;
Publication Date:
Research Org.:
Pacific Northwest National Laboratory (PNNL), Richland, WA (US), Environmental Molecular Sciences Laboratory (EMSL)
Sponsoring Org.:
USDOE
OSTI Identifier:
1324914
Report Number(s):
PNNL-SA-116408
Journal ID: ISSN 0268-1242; 48583
DOE Contract Number:
AC05-76RL01830
Resource Type:
Journal Article
Resource Relation:
Journal Name: Semiconductor Science and Technology; Journal Volume: 31; Journal Issue: 8
Country of Publication:
United States
Language:
English
Subject:
energy dispersive X-ray spectroscopy (EDS); hybrid nanostructure; composition mapping; Environmental Molecular Sciences Laboratory

Citation Formats

Zhu, Yuanyuan, Munro, Catherine J., Olszta, Matthew J., Edwards, Danny J., Braunschweig, Adam B., Knecht, Marc R., and Browning, Nigel D. Dose-rate controlled energy dispersive x-ray spectroscopic mapping of the metallic components in a biohybrid nanosystem. United States: N. p., 2016. Web. doi:10.1088/0268-1242/31/8/084002.
Zhu, Yuanyuan, Munro, Catherine J., Olszta, Matthew J., Edwards, Danny J., Braunschweig, Adam B., Knecht, Marc R., & Browning, Nigel D. Dose-rate controlled energy dispersive x-ray spectroscopic mapping of the metallic components in a biohybrid nanosystem. United States. doi:10.1088/0268-1242/31/8/084002.
Zhu, Yuanyuan, Munro, Catherine J., Olszta, Matthew J., Edwards, Danny J., Braunschweig, Adam B., Knecht, Marc R., and Browning, Nigel D. 2016. "Dose-rate controlled energy dispersive x-ray spectroscopic mapping of the metallic components in a biohybrid nanosystem". United States. doi:10.1088/0268-1242/31/8/084002.
@article{osti_1324914,
title = {Dose-rate controlled energy dispersive x-ray spectroscopic mapping of the metallic components in a biohybrid nanosystem},
author = {Zhu, Yuanyuan and Munro, Catherine J. and Olszta, Matthew J. and Edwards, Danny J. and Braunschweig, Adam B. and Knecht, Marc R. and Browning, Nigel D.},
abstractNote = {In this work, we showcase that through precise control of the electron dose rate, state-of-the-art large solid angle energy dispersive X-ray spectroscopy (EDS) mapping in aberration-corrected scanning transmission electron microscope (STEM) is capable of faithful and unambiguous chemical characterization of the Pt and Pd distribution in a peptide-mediated nanosystem. This low-dose-rate recording scheme adds another dimension of flexibility to the design of elemental mapping experiments, and holds significant potential for extending its application to a wide variety of beam sensitive hybrid nanostructures.},
doi = {10.1088/0268-1242/31/8/084002},
journal = {Semiconductor Science and Technology},
number = 8,
volume = 31,
place = {United States},
year = 2016,
month = 6
}
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  • From September, 1974 through December, 1979, a total of 249 patients with carcinoma of the cervix uteri Stage IIb and III were randomly allocated to either remotely controlled high-dose-rate intracavitary radiotherapy or manual afterloading low-dose-rate therapy, with radiotherapy of 20 Gy in 2 weeks to Point A to whole pelvis and 40 Gy in 4 weeks to the parametria. The dose to Point A by intracavitary radiotherapy was 40-60 Gy with one or two fractions in the low-dose-rate group and 30 Gy for the high-dose-rate group by 3 fractions with a once a week schedule. The purpose of this papermore » is to compare the results between the groups and to clarify the problems in the high-dose-rate group clinically. The local control rate was higher in the high-dose-rate group; however, the complication rate was also higher in this group than in the low-dose-rate group. The dose schedule and the place of rectal dose measurement is discussed. The overall cumulative survival rate was nearly the same in both groups (55% at 5 years), although some difference was noted in each stage. The most common cause of death was distant metastasis outside the pelvis and the second most common was intercurrent disease in Stage IIb and local failure in Stage III.« less
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