High-energy proton imaging for biomedical applications

Prall, Matthias; Durante, Marco; Berger, Thomas; Przybyla, B.; Graeff, C.; Lang, Phillipp M.; LaTessa, Ciara; Shestov, Less; Simoniello, P.; Danly, Christopher R.; Mariam, Fesseha Gebre; Merrill, Frank Edward; Nedrow, Paul; Wilde, Carl Huerstel; Varentsov, Dmitry

doi:10.1038/srep27651

Title: High-energy proton imaging for biomedical applications

Journal Article · Fri Jun 10 00:00:00 EDT 2016 · Scientific Reports

DOI:https://doi.org/10.1038/srep27651· OSTI ID:1321780

Prall, Matthias ^[1]; Durante, Marco ^[2]; Berger, Thomas ^[3]; Przybyla, B. ^[3]; Graeff, C. ^[1]; Lang, Phillipp M. ^[2]; LaTessa, Ciara ^[4]; Shestov, Less ^[5]; Simoniello, P. ^[1]; Danly, Christopher R. ^[6]; Mariam, Fesseha Gebre ^[6]; Merrill, Frank Edward ^[6]; Nedrow, Paul ^[6]; Wilde, Carl Huerstel ^[6]; Varentsov, Dmitry ^[1]

GSI Helmholtzzentrum fur Schwerionenforschung GmbH, Darmstadt (Germany)
GSI Helmholtzzentrum fur Schwerionenforschung GmbH, Darmstadt (Germany); Technische Univ. Darmstadt, Darmstadt (Germany)
Deutsches Zentrum fur Luft- und Raumfahrt (DLR), Cologne (Germany)
Brookhaven National Lab. (BNL), Upton, NY (United States)
GSI Helmholtzzentrum fur Schwerionenforschung GmbH, Darmstadt (Germany); Technische Univ. Darmstadt, Darmstadt (Germany); Frankfurt Institute for Advanced Studies (FIAS), Frankfurt am Main (Germany)
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

The charged particle community is looking for techniques exploiting proton interactions instead of X-ray absorption for creating images of human tissue. Due to multiple Coulomb scattering inside the measured object it has shown to be highly non-trivial to achieve sufficient spatial resolution. We present imaging of biological tissue with a proton microscope. This device relies on magnetic optics, distinguishing it from most published proton imaging methods. For these methods reducing the data acquisition time to a clinically acceptable level has turned out to be challenging. In a proton microscope, data acquisition and processing are much simpler. This device even allows imaging in real time. The primary medical application will be image guidance in proton radiosurgery. Proton images demonstrating the potential for this application are presented. As a result, tomographic reconstructions are included to raise awareness of the possibility of high-resolution proton tomography using magneto-optics.

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Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC52-06NA25396

OSTI ID:: 1321780

Report Number(s):: LA-UR-16-23081

Journal Information:: Scientific Reports, Vol. 6; ISSN 2045-2322

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 20 works

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