skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Method for producing 3-hydroxypropionic acid and other products

Patent ·
OSTI ID:1312647
; ;

This invention relates to metabolically engineered microorganism strains, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a chemical product, which includes 3-hydroxypropionic acid.

Research Organization:
Cargill, Incorporated, Wayzata, MN (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AR0000088
Assignee:
Cargill, Incorporated (Wayzata, MN)
Patent Number(s):
9,428,778
Application Number:
14/575,927
OSTI ID:
1312647
Resource Relation:
Patent File Date: 2014 Dec 18
Country of Publication:
United States
Language:
English

References (258)

Production of Organic Compounds patent October 1946
Preparation of Esters of Acrylic Acid patent March 1949
Preparation of Acrylic Acid patent May 1949
Carboxylic Polymers patent July 1957
Polyacrylic acid having high chelation value and its production patent September 1975
Unsaturated carboxylic acid-long chain alkyl ester copolymers and tri-polymers water thickening agents and emulsifiers patent October 1975
Polymers for use in water treatment patent June 1977
Acrylic acid-acrylate copolymer thickening agents patent May 1981
Manufacture of polymers of acrylic acid or methacrylic acid patent November 1981
Use of acrylamide/acrylic acid copolymers for prevention of fouling by Ca.sub.3 (PO.sub.4).sub.2 patent February 1984
Absorbent article patent May 1987
Disposable diaper having density and basis weight profiled absorbent core patent August 1987
Suspending agent for the suspension polymerization of water-soluble monomers patent November 1987
Water absorbing agent patent March 1988
Process for the continuous production of polymers and copolymers of water-soluble monomers patent August 1989
Fermentation of trichoderma reesei and apparatus therefor patent August 1990
Process for preparing water-absorbing resins patent January 1991
Thin, flexible sanitary napkin patent April 1991
Removal of residual solvent from acrylic acid polymer patent March 1992
Process for producing acid-type maleic acid polymer and water-treating agent and detergent additive containing said polymer patent August 1992
Super-absorbent polymer having improved absorbency properties patent September 1992
Process for production of water-absorbent resin patent January 1993
Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use patent October 1993
Continuous process for manufacture of a purified lactide patent December 1993
Hydrophilic, highly swellable hydrogels patent July 1994
Process for recycling aqueous fluid absorbents fines to a polymerizer patent August 1994
Process for the conversion of fine superabsorbent polymer particles into larger particles patent September 1994
Catalyzed esterification process patent June 1995
Free radical copper(II)-enolate polymerization initiators patent November 1995
Free radical initiator delivery system patent April 1996
Lactic acid production, separation and/or recovery process patent April 1996
Sanitary napkin having an internal shaping component patent September 1996
Esterification of fermentation-derived acids via pervaporation patent March 1998
Process for the production of malonic acid or a salt thereof patent October 1998
Sanitary napkin comprising an absorbent core having a density gradient patent October 1998
Mutant phosphoenolpyruvate carboxylase, its gene, and production method of amino acid patent March 1999
Method for producing L-lysine patent December 1999
Method for the production of 1,3-propanediol by recombinant microorganisms patent January 2000
Microbial production of 1,2-propanediol from sugar patent July 2000
Method for producing nucleic acid substances patent September 2001
Water-absorbing agent and production process therefor patent October 2001
Method for producing hydroxycarboxylic acids by auto-degradation of polyhydroxyalkanoates patent October 2002
Method for purifying lactic acid patent December 2002
Lactic acid processing; methods; arrangements; and, products patent March 2003
Process for preparation of D-pantothenic acid and/or salts thereof patent September 2003
Method for making auto-self-aligned top electrodes for DRAM capacitors with improved capacitor-to-bit-line-contact overlay margin patent March 2004
Acid-dyeable polymer compositions patent April 2004
Production of 3-hydroxypropionic acid in recombinant organisms patent February 2005
Methods of making amino acids using E. coli transformed with csc genes patent November 2005
Method for producing target substance by fermentation patent August 2006
Single-stage separation and esterification of cation salt carboxylates using electrodeionization patent November 2006
Nucleic acid fragments encoding nitrile hydratase and amidase enzymes from Comamonas testosteroni 5-MGAM-4D and recombinant organisms expressing those enzymes useful for the production of amides and acids patent December 2006
Methods of making intermediates from polyhydroxyalkanoates patent January 2007
3-hydroxypropionic acid and other organic compounds patent March 2007
Process for preparing carboxylic acids and derivatives thereof patent March 2007
Mutant E. coli strain with increased succinic acid production patent May 2007
Process for separating and recovering 3-hydroxypropionic acid and acrylic acid patent October 2007
Nucleic acid fragments encoding nitrile hydratase and amidase enzymes from Comamonas testosteroni 5-MGAM-4D and recombinant organisms expressing those enzymes useful for the production of amides and acids patent October 2007
Alanine 2,3-Aminomutase patent December 2007
Increasing intracellular NADPH availability in E. coli patent February 2008
Production of 3-hydroxycarboxylic acid using nitrilase mutants patent April 2008
3-Hydroxypropionic acid and other organic compounds patent July 2008
Utilization of fructose in microbial production strains patent April 2009
Preparation of acrylic acid derivatives from α- or β-hydroxy carboxylic acids patent May 2009
3-hydroxypropionic acid and other organic compounds patent December 2009
Atom or group transfer radical polymerization patent March 2010
Method for conversion of β-hydroxy carbonyl compounds patent March 2010
Method for redesign of microbial production systems patent November 2010
Amino acid producing microorganism and a method for producing an amino acid patent November 2010
Biosynthesis of phloroglucinol and preparation of 1,3-dihydroxybenzene therefrom patent May 2011
Compositions and methods for 3-hydroxypropionate bio-production from biomass patent November 2011
Method for producing an organic acid patent December 2011
Compositions and methods for 3-hydroxypropionate bio-production from biomass patent February 2014
Genetically modified organisms for increased microbial production of 3-hydroxypropionic acid involving an oxaloacetate alpha-decarboxylase patent August 2014
Methods for producing 3-hydroxypropionic acid and other products patent November 2014
Production of Polyhydroxyalkanoates From Polyols patent-application November 2002
Schizochytrium PKS Genes patent-application May 2003
Novel Antimicrobial Activity of Gemfibrozil and Related Compounds and Derivatives and Metabolites Thereof patent-application October 2003
Bioabsorbable Polymer Containing 2-hydroxyacid Monomers patent-application November 2003
Expression of microbial proteins in plants for production of plants with improved properties patent-application December 2003
Production Of Polyketides patent-application December 2003
Method For Determining Gene Knockouts patent-application January 2004
3-hydroxypropionic Acid And Other Organic Compounds patent-application April 2004
Materials and methods for the efficient production of acetate and other products patent-application August 2004
Process for the Biological Production of 1,3-propanediol With High Yield patent-application August 2004
Synthesis of 1,2,3,4-tetrahydroxybenzenes From Biomass-derived Carbon patent-application October 2004
Process for Preparing Carboxylic Acids and Derivatives Thereof patent-application October 2004
Process for the production of L-amino acids using strains of the enterobacteriaceae family patent-application October 2004
Method for the Preparation of an Evolved Microorganism for the Creation or the Modification of Metabolic Pathways patent-application March 2005
Novel Enoyl Reductases and Methods of Use Thereof patent-application September 2005
Alanine 2,3,aminomutase patent-application October 2005
Preparation of acrylic acid derivatives from alpha-or beta-hydroxy carboxylic acids patent-application October 2005
Production Of Fermentation Product patent-application October 2005
Polyhydroxyalkanoate Production From Polyols patent-application October 2005
Process For Production And Purification Of Fermentation Derived Organic Acids patent-application December 2005
Process for Preparation of 1,3-propanediol patent-application December 2005
Process for Production of Organic Acid Esters patent-application January 2006
Mixed-library Parallel Gene Mapping Quantitative Micro-array Technique For Genome-wide Identification Of Trait Conferring Genes patent-application April 2006
Instruments And Methods For Accessing An Anatomic Space patent-application January 2007
Optimised Micro-organism Strains For Nadph-consuming Biosynthetic Pathways patent-application April 2007
Production of 3-hydropropionic Acid Using Beta-alanine/pyruvate Aminotransferase patent-application May 2007
Process For Producing 1,3-propanediol and/or 3-hydroxypropionic Acid patent-application June 2007
3-hydroxypropionic acid and other organic compounds patent-application August 2007
Method and Apparatus for Conversion of Beta-hydroxy Carbonyl Compounds patent-application September 2007
Polyunsaturated fatty acid production in heterologous organisms using PUFA polyketide synthase systems patent-application October 2007
3-Hydroxypropionic Acid And Other Organic Compounds patent-application March 2008
Alanine 2, 3-aminomutase patent-application May 2008
Energy Efficient Methods To Produce Products patent-application August 2008
Methods and Organisms for Growth-Coupled Production of 3-Hydroxypropionic Acid patent-application August 2008
Membrane Supported Bioreactor For Conversion Of Syngas Components To Liquid Products patent-application January 2009
Water-absorbent polymer structures based on renewable resources and method for producing said structures patent-application January 2009
Alanine 2, 3 Aminomutases patent-application January 2009
3-hydroxypropionic acid and other organic compounds patent-application February 2009
Process for Converting a Hydroxycarboxylic Acid, or Salts Thereof, to an Unsaturated Carboxylic Acid and/or Its Esters patent-application March 2009
Method for the Production of Resveratrol in a Recombinant Oleaginous Microorganism patent-application March 2009
Production of Polyketides patent-application April 2009
Strain for butanol production patent-application August 2009
Methods and Composition for Extraction and Transesterification of Biomass Components patent-application September 2009
Beta-alanine/alpha-ketoglutarate Aminotransferase for 3-hydroxypropionic Acid Production patent-application November 2009
Methods of manufacturing derivatives of beta-hydroxycarboxylic acids patent-application December 2009
Deletion mutants for the production of isobutanol patent-application December 2009
Microbiological Production Of 3-Hydroxypropionic Acid patent-application December 2009
Carboxylic Acids Prepared Using a Salt-Splitting Process patent-application April 2010
Biological Synthesis Of Difunctional Alkanes From Carbohydrate Feedstocks patent-application June 2010
Compositions and Methods for Enhancing Tolerance for the Production of Organic Chemicals Produced by Microorganisms patent-application August 2010
Purification of aqueous solutions of organic acids patent-application April 2011
Production of an Organic Acid and/or Related Chemicals patent-application May 2011
Process for the Biological Production of 3-Hydroxypropionic Acid with High Yield patent-application June 2011
Biosynthesis Of Phloroglucinol And Preparation Of 1,3-Dihydroxybenzene Therefrom patent-application July 2011
Methods, systems and compositions for increased microorganism tolerance to and production of 3-hydroxypropionic acid (3-HP) patent-application October 2011
Carboxylic acid recovery and methods related thereto patent-application November 2011
Compositions and methods for 3-hydroxypropionate bio-production from biomass patent-application February 2012
3-Hydroxypropionic Acid and Other Organic Compounds patent-application September 2012
Methods, Systems And Compositions For Increased Microorganism Tolerance To And Production Of 3-Hydroxypropionic Acid (3-HP) patent-application October 2012
Methods for producing 3-hydroxypropionic acid and other products patent-application March 2013
Microorganism Production of High-Value Chemical Products, and Related Compositions, Methods and Systems patent-application May 2013
Methods, Systems And Compositions Related To Reduction Of Conversions Of Microbially Produced 3-Hydroxyproplonic Acid (3-HP) To Aldehyde Metabolites patent-application July 2013
Purification Of 3-Hydroxypropionic Acid From Crude Cell Broth And Production Of Acrylamide patent-application December 2013
Compositions and methods for 3-hydroxypropionate bio-production from biomass patent-application May 2014
Purification of 3-Hydroxypropionic Acid from Crude Cell Broth and Production of Acrylamide patent-application October 2014
Microorganism production of high-value chemical products, and related compositions, methods and systems patent-application February 2015
Methods, systems, and compositions for increased microorganism tolerance to and production of 3-hydroxypropionic acid (3-HP) patent-application February 2015
Flash evaporation for product purification and recovery patent-application February 2015
Genetically Modified Organisms for Increased Microbial Production of 3-Hydroxypropionic acid Involving an Oxaloacetate Alpha-Decarboxylase patent-application March 2015
Methods, Systems and Compositions Related to Reduction of Conversion of Microbially Produced 3-Hydroxypropionic Acid (3-HP) to Aldehyde Metabolites patent-application March 2015
Malonyl-Coenzyme A Reductase in the Modified 3-Hydroxypropionate Cycle for Autotrophic Carbon Fixation in Archaeal Metallosphaera and Sulfolobus spp. journal October 2006
Sequencing and overexpression of the Escherichia coli aroE gene encoding shikimate dehydrogenase journal January 1988
A New Enzymatic Method of Acrylamide Production journal May 1982
Inverse metabolic engineering: A strategy for directed genetic engineering of useful phenotypes journal July 2002
Induction of specific base-pair substitutions in E. coli trpA mutants by chloroenthylene oxide, a carcinogenic vinyl chloride metabolite journal November 1985
Engineered ketol-acid reductoisomerase and alcohol dehydrogenase enable anaerobic 2-methylpropan-1-ol production at theoretical yield in Escherichia coli journal May 2011
The biological degradation of cellulose journal January 1994
Sequences of the envM gene and of two mutated alleles in Escherichia coli journal October 1992
Naturally Occurring Adenines within mRNA Coding Sequences Affect Ribosome Binding and Expression in Escherichia coli journal November 2006
Catalytic Plasticity of Fatty Acid Modification Enzymes Underlying Chemical Diversity of Plant Lipids journal November 1998
Synthesis of labeled acrylamide andN-methylolacrylamide (NMA):15N-acrylamide,13C-NMA,15N-NMA, and13C,15N-NMA journal January 2005
The IdhA Gene Encoding the Fermentative Lactate Dehydrogenase of Escherichia Coli journal January 1997
Directed Evolution of Toluene ortho-Monooxygenase for Enhanced 1-Naphthol Synthesis and Chlorinated Ethene Degradation journal January 2002
Semi-rational approaches to engineering enzyme activity: combining the benefits of directed evolution and rational design journal August 2005
Simultaneous synthesis of enantiomerically pure (S)-amino acids and (R)-amines using coupled transaminase reactions journal January 2003
The commercial production of chemicals using pathway engineering journal December 2000
Inhibitory activity spectrum of reuterin produced by Lactobacillus reuteri against intestinal bacteria journal January 2007
DNA shuffling of a family of genes from diverse species accelerates directed evolution journal January 1998
Cloning, crystallization and preliminary characterization of a β-carbonic anhydrase from Escherichia coli journal September 2000
Thermal regulation of membrane lipid fluidity in bacteria journal February 1983
Practical limits of function prediction journal January 2000
The Shikimate Pathway: Aromatic Amino Acids and Phenylpropanoids book January 2009
Engineering of a functional human NADH-dependent cytochrome P450 system journal January 2001
Structure of the EntB Multidomain Nonribosomal Peptide Synthetase and Functional Analysis of Its Interaction with the EntE Adenylation Domain journal April 2006
Lactate-Utilizing Bacteria, Isolated from Human Feces, That Produce Butyrate as a Major Fermentation Product journal October 2004
The overexpression and complete amino acid sequence of Escherichia coli 3-dehydroquinase journal September 1986
Switch of coenzyme specificity of p -hydroxybenzoate hydroxylase 1 1Edited by A. R. Fersht journal September 1999
Improving lycopene production in Escherichia coli by engineering metabolic control journal May 2000
Biorefineries:  Current Status, Challenges, and Future Direction journal July 2006
A Novel Quinone-forming Monooxygenase Family Involved in Modification of Aromatic Polyketides journal February 2005
Genome-wide screening for trait conferring genes using DNA microarrays journal May 2002
Identification and cloning of the Mycobacterium avium folA gene, required for dihydrofolate reductase activity journal November 1997
Metabolic Analysis of Escherichia coli in the Presence and Absence of the Carboxylating Enzymes Phosphoenolpyruvate Carboxylase and Pyruvate Carboxylase journal May 2000
Monofunctional chorismate mutase from Bacillus subtilis: purification of the protein, molecular cloning of the gene, and overexpression of the gene product in Escherichia coli journal January 1990
Overproduction of phage Lambda repressor under control of the lac promotor of Escherichia coli journal January 1976
Genetic Evidence for an Interaction of the UbiG O-Methyltransferase with UbiX in Escherichia coli Coenzyme Q Biosynthesis journal August 2006
Structure–function analysis of NADPH:nitrate reductase from Aspergillus nidulans: analysis of altered pyridine nucleotide specificity in vivo journal June 2000
Exploring the diversity of complex metabolic networks journal December 2004
A T42M Substitution in Bacterial 5-Enolpyruvylshikimate-3-phosphate Synthase (EPSPS) Generates Enzymes with Increased Resistance to Glyphosate journal January 2003
Enoyl-Acyl Carrier Protein Reductase ( fabI ) Plays a Determinant Role in Completing Cycles of Fatty Acid Elongation in Escherichia coli journal November 1995
Oxidation of Cysteine 645 of Cobalamin-Independent Methionine Synthase Causes a Methionine Limitation in Escherichia coli journal March 2009
Malonyl-Coenzyme A Reductase from Chloroflexus aurantiacus, a Key Enzyme of the 3-Hydroxypropionate Cycle for Autotrophic CO2 Fixation journal May 2002
Biosynthetic pathways for 3-hydroxypropionic acid production journal February 2009
Purification and characterization of 2-oxoglutarate decarboxylase of Leuconostoc oenos journal August 1990
Engineering primary metabolic pathways of industrial micro-organisms journal March 2007
Extractive recovery of products from fermentation broths journal April 1999
The Rut Pathway for Pyrimidine Degradation: Novel Chemistry and Toxicity Problems journal April 2010
Dihydrolipoamide Dehydrogenase Mutation Alters the NADH Sensitivity of Pyruvate Dehydrogenase Complex of Escherichia coli K-12 journal March 2008
Effect of Overexpression of Actinobacillus succinogenes Phosphoenolpyruvate Carboxykinase on Succinate Production in Escherichia coli journal February 2004
A "Silent" Polymorphism in the MDR1 Gene Changes Substrate Specificity journal January 2007
Polypeptide Release Factors in Prokaryotes and Eukaryotes journal January 2002
Reactions of β-lactones with potassium alkoxides and their complexes with 18-crown-6 in aprotic solvents journal July 1993
A Physiology Study of Escherichia coli Overexpressing Phosphoenolpyruvate Carboxykinase journal April 2008
A new preparation of trifluoromethanesulfinate salts journal July 2007
A process for microbial hydrocarbon synthesis: Overproduction of fatty acids in Escherichia coli and catalytic conversion to alkanes journal June 2010
Effect of poxB gene knockout on metabolism in Escherichia coli based on growth characteristics and enzyme activities journal September 2006
Fe2(SO4)3·4H2O/concentrated H2SO4: an efficient catalyst for esterification journal March 2004
Feedback Inhibition of Chorismate Mutase/Prephenate Dehydrogenase (TyrA) of Escherichia coli: Generation and Characterization of Tyrosine-Insensitive Mutants journal November 2005
SCALEs: multiscale analysis of library enrichment journal November 2006
Engineering a mevalonate pathway in Escherichia coli for production of terpenoids journal June 2003
Aminotransferases: demonstration of homology and division into evolutionary subgroups journal June 1993
Effect of process parameters on 3-hydroxypropionic acid production from glycerol using a recombinant Escherichia coli journal April 2009
Diversion of the Metabolic Flux from Pyruvate Dehydrogenase to Pyruvate Oxidase Decreases Oxidative Stress during Glucose Metabolism in Nongrowing Escherichia coli Cells Incubated under Aerobic, Phosphate Starvation Conditions journal October 2004
The Lysine Decarboxylase CadA Protects Escherichia coli Starved of Phosphate against Fermentation Acids journal January 2007
Human Catechol-O-Methyltransferase Haplotypes Modulate Protein Expression by Altering mRNA Secondary Structure journal December 2006
A novel methodology employing Corynebacterium glutamicum genome information to generate a new L -lysine-producing mutant journal January 2002
Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway journal June 2010
Cloning and Overexpression in Soluble Form of Functional Shikimate Kinase and 5-Enolpyruvylshikimate 3-Phosphate Synthase Enzymes from Mycobacterium tuberculosis journal August 2001
Metabolic engineering of aromatic group amino acid pathway in Bacillus subtilis for L-phenylalanine production journal November 2004
Directed evolution of RuBisCO hypermorphs through genetic selection in engineered E.coli journal January 2006
Genome shuffling of Lactobacillus for improved acid tolerance journal July 2002
A new perspective on thiamine catalysis journal August 2004
Polyphosphate Kinase Protects Salmonella enterica from Weak Organic Acid Stress journal April 2005
A mild and efficient method for esterification and transesterification catalyzed by iodine journal January 2002
Molecular Iodine in Ionic Liquid: A Green Catalytic System for Esterification and Transesterification journal May 2010
Structure−Cytoprotective Activity Relationship of Simple Molecules Containing an α,β-Unsaturated Carbonyl System journal June 1997
Silent Polymorphisms Speak: How They Affect Pharmacogenomics and the Treatment of Cancer journal October 2007
Molecular breeding of carotenoid biosynthetic pathways journal July 2000
Melamine Deaminase and Atrazine Chlorohydrolase: 98 Percent Identical but Functionally Different journal April 2001
Developments in Directed Evolution for Improving Enzyme Functions journal August 2007
CHEMISTRY: Sugary Recipe Boosts Grow-Your-Own Plastics journal June 2006
Genes restoring redox balance in fermentation-deficient E. coli NZN111 journal November 2009
The ARO4 gene of Candida albicans encodes a tyrosine-sensitive DAHP synthase: evolution, functional conservation and phenotype of Aro3p-, Aro4p-deficient mutants journal May 2002
Challenges in Engineering Microbes for Biofuels Production journal February 2007
Feasibility of acrylic acid production by fermentation journal February 2005
Enzymes of a novel autotrophic CO2 fixation pathway in the phototrophic bacterium Chloroflexus aurantiacus, the 3-hydroxypropionate cycle journal August 1993
Changes in the Intracellular Concentration of Acetyl-CoA and Malonyl-CoA in Relation to the Carbon and Energy Metabolism of Escherichia coli K12 journal August 1988
Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: Identification of α-ketoglutarate decarboxylase journal July 2005
3-phenylpropionate catabolism and the Escherichia coli oxidative stress response journal April 2005
A genomics approach to improve the analysis and design of strain selections journal May 2008
Identification of a 21 amino acid peptide conferring 3-hydroxypropionic acid stress-tolerance to Escherichia coli journal January 2012
Rapid dissection of a complex phenotype through genomic-scale mapping of fitness altering genes journal May 2010
Fermentation of Glucose to Lactic Acid Coupled with Reactive Extraction:  A Review journal September 2004
The overexpression, purification and complete amino acid sequence of chorismate synthase from Escherichia coli K12 and its comparison with the enzyme from Neurospora crassa journal April 1988
A Single Mutation Converts a Novel Phosphotyrosine Binding Domain into a Dual-specificity Phosphatase journal November 1995
Conversion of a β-Ketoacyl Synthase to a Malonyl Decarboxylase by Replacement of the Active-Site Cysteine with Glutamine journal September 1999
On the Role of Helix 0 of the Tryptophan Synthetase α Chain of Escherichia coli journal June 1996
Identification of PhoB binding sites of the yibD and ytfK promoter regions in Escherichia coli journal April 2011
Improving cellular malonyl-CoA level in Escherichia coli via metabolic engineering journal May 2009
Binding of Two Flaviolin Substrate Molecules, Oxidative Coupling, and Crystal Structure of Streptomyces coelicolor A3(2) Cytochrome P450 158A2 journal January 2005
Interdomain Communication between the Thiolation and Thioesterase Domains of EntF Explored by Combinatorial Mutagenesis and Selection journal August 2006
The Enoyl-[Acyl-Carrier-Protein] Reductase (FabI) of Escherichia coli, which Catalyzes a Key Regulatory Step in Fatty Acid Biosynthesis, Accepts NADH and NADPH as Cofactors and is Inhibited by Palmitoyl-CoA journal December 1996
A core catalytic domain of the TyrA protein family: arogenate dehydrogenase from Synechocystis journal August 2004
Selective production of L-aspartic acid and L-phenylalanine by coupling reactions of aspartase and aminotransferase in Escherichia coli journal July 2000
FolM, A New Chromosomally Encoded Dihydrofolate Reductase in Escherichia coli journal November 2003
The qmeA (ts) mutation of Escherichia coli is localized in the fabI gene, which encodes enoyl-ACP reductase journal January 1996
Characterization of two temperature-inducible promoters newly isolated from B. subtilis journal July 2007
De novo biosynthetic pathways: rational design of microbial chemical factories journal October 2008
Overexpression, Purification, and Characterization of Tyrosine-Sensitive 3-Deoxy-d-arabino-heptulosonic Acid 7-Phosphate Synthase fromEscherichia coli journal March 1997
Inhibition of Escherichia coli growth by acetic acid: a problem with methionine biosynthesis and homocysteine toxicity journal July 2002
Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli journal December 2002
Inhibiting Bacterial Fatty Acid Synthesis journal April 2006
?-hydroxypropionic acid production by Byssochlamys sp. grown on acrylic acid journal November 1993

Similar Records

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY