Peptide and protein biomarkers for type 1 diabetes mellitus

Zhang, Qibin; Metz, Thomas O.

Title: Peptide and protein biomarkers for type 1 diabetes mellitus

Patent · Tue Aug 30 00:00:00 EDT 2016

OSTI ID:1311866

Zhang, Qibin; Metz, Thomas O.

A method for identifying persons with increased risk of developing type 1 diabetes mellitus, or having type I diabetes mellitus, utilizing selected biomarkers described herein either alone or in combination. The present disclosure allows for broad based, reliable, screening of large population bases. Also provided are arrays and kits that can be used to perform such methods.

View Patent

Cite

Export

Save

Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC05-76RL01830

Assignee:: Battelle Memorial Institute (Richland, WA)

Patent Number(s):: 9,429,569

Application Number:: 14/268,002

OSTI ID:: 1311866

Resource Relation:: Patent File Date: 2014 May 02

Country of Publication:: United States

Language:: English

References (37)

Method for identifying type I diabetes mellitus in humans Metz, Thomas O.; Qian, Weijun; Jacobs, Jon M. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090117578 US Patent Application 12/291173; 20090117578	patent-application	May 2009
Protein biomarkers and therapeutic targets for autoimmune and alloimmune diseaes Chance, Mark; Cooke, Kenneth; Schlatzer, Daniela https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20120077209 US Patent Application 13/375523; 20120077209	patent-application	March 2012
Composition and Methods for Diagnosis and Prognosis of Colorectal Cancer Aw, Eva I-Wei https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20120149022 US Patent Application 13/148881; 20120149022	patent-application	June 2012
Methods for Detecting Pre-Diabetes and Diabetes Using Differential Protein Glycosylation Nagalia, Srinivasa R.; Roberts, Charles T. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20120208218 US Patent Application 13/457243; 20120208218	patent-application	August 2012
Quantitative Mass Spectrometric Multiple Reaction Monitoring Assays for Major Plasma Proteins Anderson, Leigh; Hunter, Christie L. Molecular & Cellular Proteomics, Vol. 5, Issue 4 https://doi.org/10.1074/mcp.M500331-MCP200	journal	December 2005
Prediction of Autoantibody Positivity and Progression to Type 1 Diabetes: Diabetes Autoimmunity Study in the Young (DAISY) Barker, Jennifer M.; Barriga, Katherine J.; Yu, Liping The Journal of Clinical Endocrinology & Metabolism, Vol. 89, Issue 8 https://doi.org/10.1210/jc.2003-031887	journal	August 2004
Diabetes Antibody Standardization Program: First Assay Proficiency Evaluation Bingley, P. J.; Bonifacio, E.; Mueller, P. W. Diabetes, Vol. 52, Issue 5 https://doi.org/10.2337/diabetes.52.5.1128	journal	May 2003
Measurement of islet cell antibodies in the Type 1 Diabetes Genetics Consortium: efforts to harmonize procedures among the laboratories Bingley, Polly J.; Williams, Alistair JK; Colman, Peter G. Clinical Trials: Journal of the Society for Clinical Trials, Vol. 7, Issue 1_suppl https://doi.org/10.1177/1740774510373496	journal	July 2010
Plasma Gelsolin: Function, Prognostic Value, and Potential Therapeutic Use Bucki, Robert; Levental, Ilya; Kulakowska, Alina Current Protein & Peptide Science, Vol. 9, Issue 6 https://doi.org/10.2174/138920308786733912	journal	December 2008
Normalization Approaches for Removing Systematic Biases Associated with Mass Spectrometry and Label-Free Proteomics Callister, Stephen J.; Barry, Richard C.; Adkins, Joshua N. Journal of Proteome Research, Vol. 5, Issue 2 https://doi.org/10.1021/pr050300l	journal	February 2006
Type 1 diabetes: entering the proteomic era D’Hertog, Wannes; Mathieu, Chantal; Overbergh, Lut Expert Review of Proteomics, Vol. 3, Issue 2 https://doi.org/10.1586/14789450.3.2.223	journal	April 2006
Proteomics and naturally occurring animal diseases: Opportunities for animal and human medicine Doherty, Mary K.; Beynon, Robert J.; Whitfield, Phillip D. PROTEOMICS – CLINICAL APPLICATIONS, Vol. 2, Issue 2 https://doi.org/10.1002/prca.200780085	journal	February 2008
Development of a fibrinogen-specific sandwich enzyme-linked immunosorbent assay microarray assay for distinguishing between blood plasma and serum samples Gonzalez, Rachel M.; Zhang, Qibin; Zangar, Richard C. Analytical Biochemistry, Vol. 414, Issue 1, p. 99-102 https://doi.org/10.1016/j.ab.2011.02.039	journal	July 2011
The Environmental Determinants of Diabetes in the Young (TEDDY): genetic criteria and international diabetes risk screening of 421 000 infants Hagopian, William A.; Erlich, Henry; Lernmark, Åke Pediatric Diabetes, Vol. 12, Issue 8 https://doi.org/10.1111/j.1399-5448.2011.00774.x	journal	May 2011
Comparative aspects of diabetes mellitus in dogs and cats Hoenig, M. Molecular and Cellular Endocrinology, Vol. 197, Issue 1-2 https://doi.org/10.1016/S0303-7207(02)00264-2	journal	November 2002
High-Abundance Polypeptides of the Human Plasma Proteome Comprising the Top 4 Logs of Polypeptide Abundance Hortin, G. L.; Sviridov, D.; Anderson, N. L. Clinical Chemistry, Vol. 54, Issue 10 https://doi.org/10.1373/clinchem.2008.108175	journal	August 2008
Decon2LS: An open-source software package for automated processing and visualization of high resolution mass spectrometry data Jaitly, Navdeep; Mayampurath, Anoop; Littlefield, Kyle BMC Bioinformatics, Vol. 10, Issue 1 https://doi.org/10.1186/1471-2105-10-87	journal	January 2009
Environmental Triggers and Determinants of Type 1 Diabetes Knip, M.; Veijola, R.; Virtanen, S. M. Diabetes, Vol. 54, Issue Supplement 2 https://doi.org/10.2337/diabetes.54.suppl_2.S125	journal	November 2005
Thrombocidins, Microbicidal Proteins from Human Blood Platelets, Are C-terminal Deletion Products of CXC Chemokines Krijgsveld, Jeroen; Zaat, Sebastian A. J.; Meeldijk, Jan Journal of Biological Chemistry, Vol. 275, Issue 27 https://doi.org/10.1074/jbc.275.27.20374	journal	June 2000
Multiple Reaction Monitoring-based, Multiplexed, Absolute Quantitation of 45 Proteins in Human Plasma Kuzyk, Michael A.; Smith, Derek; Yang, Juncong Molecular & Cellular Proteomics, Vol. 8, Issue 8 https://doi.org/10.1074/mcp.M800540-MCP200	journal	May 2009
Potentiation of C1 Esterase Inhibitor by StcE, a Metalloprotease Secreted by Escherichia coli O157:H7 Lathem, Wyndham W.; Bergsbaken, Tessa; Welch, Rodney A. The Journal of Experimental Medicine, Vol. 199, Issue 8 https://doi.org/10.1084/jem.20030255	journal	April 2004
Fully Automated Four-Column Capillary LC−MS System for Maximizing Throughput in Proteomic Analyses Livesay, Eric A.; Tang, Keqi; Taylor, Beverley K. Analytical Chemistry, Vol. 80, Issue 1 https://doi.org/10.1021/ac701727r	journal	January 2008
Effect of Collision Energy Optimization on the Measurement of Peptides by Selected Reaction Monitoring (SRM) Mass Spectrometry MacLean, Brendan; Tomazela, Daniela M.; Abbatiello, Susan E. Analytical Chemistry, Vol. 82, Issue 24 https://doi.org/10.1021/ac102179j	journal	December 2010
Application of Proteomics in the Discovery of Candidate Protein Biomarkers in a Diabetes Autoantibody Standardization Program Sample Subset Metz, Thomas O.; Qian, Wei-Jun; Jacobs, Jon M. Journal of Proteome Research, Vol. 7, Issue 2 https://doi.org/10.1021/pr700606w	journal	February 2008
VIPER: an advanced software package to support high-throughput LC-MS peptide identification Monroe, Matthew E.; Tolić, Nikola; Jaitly, Navdeep Bioinformatics, Vol. 23, Issue 15 https://doi.org/10.1093/bioinformatics/btm281	journal	June 2007
Interpretation of Shotgun Proteomic Data: The Protein Inference Problem Nesvizhskii, Alexey I.; Aebersold, Ruedi Molecular & Cellular Proteomics, Vol. 4, Issue 10 https://doi.org/10.1074/mcp.R500012-MCP200	journal	July 2005
Improved Peptide Elution Time Prediction for Reversed-Phase Liquid Chromatography-MS by Incorporating Peptide Sequence Information Petritis, Konstantinos; Kangas, Lars J.; Yan, Bo Analytical Chemistry, Vol. 78, Issue 14 https://doi.org/10.1021/ac060143p	journal	July 2006
Primer: Immunity and Autoimmunity Pietropaolo, M.; Surhigh, J. M.; Nelson, P. W. Diabetes, Vol. 57, Issue 11 https://doi.org/10.2337/db07-1691	journal	October 2008
Targeted proteomic strategy for clinical biomarker discovery Schiess, Ralph; Wollscheid, Bernd; Aebersold, Ruedi Molecular Oncology, Vol. 3, Issue 1, p. 33-44 https://doi.org/10.1016/j.molonc.2008.12.001	journal	December 2008
Diabetes Antibody Standardization Program: evaluation of assays for insulin autoantibodies Schlosser, M.; Mueller, P. W.; Törn, C. Diabetologia, Vol. 53, Issue 12 https://doi.org/10.1007/s00125-010-1915-5	journal	September 2010
Distinct Cerebrospinal Fluid Proteomes Differentiate Post-Treatment Lyme Disease from Chronic Fatigue Syndrome Schutzer, Steven E.; Angel, Thomas E.; Liu, Tao PLoS ONE, Vol. 6, Issue 2 https://doi.org/10.1371/journal.pone.0017287	journal	February 2011
Enterovirus Infection and Progression From Islet Autoimmunity to Type 1 Diabetes: The Diabetes and Autoimmunity Study in the Young (DAISY) Stene, L. C.; Oikarinen, S.; Hyoty, H. Diabetes, Vol. 59, Issue 12 https://doi.org/10.2337/db10-0866	journal	September 2010
Insulin-Dependent Diabetes Mellitus Tisch, Roland; McDevitt, Hugh Cell, Vol. 85, Issue 3 https://doi.org/10.1016/S0092-8674(00)81106-X	journal	May 1996
Diabetes Antibody Standardization Program: evaluation of assays for autoantibodies to glutamic acid decarboxylase and islet antigen-2 Törn, C.; Mueller, P. W.; Schlosser, M. Diabetologia, Vol. 51, Issue 5 https://doi.org/10.1007/s00125-008-0967-2	journal	March 2008
An Inflammatory Gene-Expression Fingerprint in Monocytes of Autoimmune Thyroid Disease Patients van der Heul-Nieuwenhuijsen, Leonie; Padmos, Roos C.; Drexhage, Roosmarijn C. The Journal of Clinical Endocrinology & Metabolism, Vol. 95, Issue 4 https://doi.org/10.1210/jc.2009-1455	journal	April 2010
Prediction of Low-Energy Collision-Induced Dissociation Spectra of Peptides Zhang, Zhongqi Analytical Chemistry, Vol. 76, Issue 14 https://doi.org/10.1021/ac049951b	journal	July 2004
Advances in proteomics data analysis and display using an accurate mass and time tag approach Zimmer, Jennifer S. D.; Monroe, Matthew E.; Qian, Wei-Jun Mass Spectrometry Reviews, Vol. 25, Issue 3 https://doi.org/10.1002/mas.20071	journal	January 2006

Similar Records

Peptide and protein biomarkers for type 1 diabetes mellitus

Patent · Tue Jun 10 00:00:00 EDT 2014 · OSTI ID:1311866

Zhang, Qibin; Metz, Thomas O.

Serum markers for type II diabetes mellitus

Patent · Tue Mar 18 00:00:00 EDT 2014 · OSTI ID:1311866

Metz, Thomas O; Qian, Wei-Jun; Jacobs, Jon M; +3 more

MicroRNAs as biomarkers of diabetic retinopathy and disease progression

Journal Article · Fri Nov 01 00:00:00 EDT 2019 · Neural Regeneration Research · OSTI ID:1311866

Martinez, Bridget; Peplow, PhilipV

Related Subjects

60 APPLIED LIFE SCIENCES
59 BASIC BIOLOGICAL SCIENCES

Title: Peptide and protein biomarkers for type 1 diabetes mellitus

Citation Formats

References (37)

Similar Records

Related Subjects