Broadly targeted CD8+ T cell responses restricted by major histocompatibility complex E

Hansen, S. G.; Wu, H. L.; Burwitz, B. J.; Hughes, C. M.; Hammond, K. B.; Ventura, A. B.; Reed, J. S.; Gilbride, R. M.; Ainslie, E.; Morrow, D. W.; Ford, J. C.; Selseth, A. N.; Pathak, R.; Malouli, D.; Legasse, A. W.; Axthelm, M. K.; Nelson, J. A.; Gillespie, G. M.; Walters, L. C.; Brackenridge, S.; Sharpe, H. R.; Lopez, C. A.; Fruh, K.; Korber, B. T.; McMichael, A. J.; Gnanakaran, S.; Sacha, J. B.; Picker, L. J.

doi:10.1126/science.aac9475

Title: Broadly targeted CD8+ T cell responses restricted by major histocompatibility complex E

Journal Article · Thu Jan 21 00:00:00 EST 2016 · Science

DOI:https://doi.org/10.1126/science.aac9475· OSTI ID:1355834

Hansen, S. G.; Wu, H. L.; Burwitz, B. J.; Hughes, C. M.; Hammond, K. B.; Ventura, A. B.; Reed, J. S.; Gilbride, R. M.; Ainslie, E.; Morrow, D. W.; Ford, J. C.; Selseth, A. N.; Pathak, R.; Malouli, D.; Legasse, A. W.; Axthelm, M. K.; Nelson, J. A.; Gillespie, G. M.; Walters, L. C.; Brackenridge, S. more »

Major histocompatibility complex (MHC)-E is a highly conserved, ubiquitously expressed, nonclassical, MHC-Ib molecule with limited polymorphism primarily involved in regulation of NK cell reactivity via interaction with NKG2/CD94 receptors. We found that vaccination of rhesus macaques with Rh157.5/.4 gene-deleted rhesus Cytomegalovirus (RhCMV) vectors uniquely diverts MHC-E function to presentation of highly diverse peptide epitopes to CD8α/β⁺ T cells, approximately 4 distinct epitopes per 100 amino acids, in all tested protein antigens. Computational structural analysis revealed that a relatively stable, open binding groove in MHC-E attains broad peptide binding specificity by imposing a similar backbone configuration on bound peptides with few restrictions based on amino acid side chains. Since MHC-E is up-regulated on cells infected with HIV/SIV and other persistent viruses to evade NK cell activity, MHC-E-restricted CD8⁺ T cell responses have the potential to exploit pathogen immune evasion adaptations, a capability that might endow these unconventional responses with superior efficacy.

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Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE National Nuclear Security Administration (NNSA); National Institutes of Health (NIH); Work for Others (WFO)

Grant/Contract Number:: AC52-06NA25396; 1K01DK094941; 5U01DK89572; DK104211; 5-CDA2014210-A-N; 1R01DK081166

OSTI ID:: 1355834

Alternate ID(s):: OSTI ID: 1304811

Report Number(s):: LA-UR-15-24868; science.aac9475

Journal Information:: Science, Journal Name: Science Vol. 351 Journal Issue: 6274; ISSN 0036-8075

Publisher:: American Association for the Advancement of Science (AAAS)Copyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 198 works

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References (51)

Immune clearance of highly pathogenic SIV infection Hansen, Scott G.; Jr, Michael Piatak; Ventura, Abigail B. Nature, Vol. 502, Issue 7469 https://doi.org/10.1038/nature12519	journal	September 2013
Acute phase cytotoxic T lymphocyte escape is a hallmark of simian immunodeficiency virus infection O'Connor, David H.; Allen, Todd M.; Vogel, Thorsten U. Nature Medicine, Vol. 8, Issue 5 https://doi.org/10.1038/nm0502-493	journal	May 2002
Subtle Changes in Peptide Conformation Profoundly Affect Recognition of the Non-Classical MHC Class I Molecule HLA-E by the CD94–NKG2 Natural Killer Cell Receptors Hoare, Hilary L.; Sullivan, Lucy C.; Clements, Craig S. Journal of Molecular Biology, Vol. 377, Issue 5 https://doi.org/10.1016/j.jmb.2008.01.098	journal	April 2008
Viral modulation of NK cell immunity Lodoen, Melissa B.; Lanier, Lewis L. Nature Reviews Microbiology, Vol. 3, Issue 1 https://doi.org/10.1038/nrmicro1066	journal	January 2005
Cytomegalovirus Vectors Violate CD8+ T Cell Epitope Recognition Paradigms Hansen, S. G.; Sacha, J. B.; Hughes, C. M. Science, Vol. 340, Issue 6135 https://doi.org/10.1126/science.1237874	journal	May 2013
Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge Hansen, Scott G.; Vieville, Cassandra; Whizin, Nathan Nature Medicine, Vol. 15, Issue 3 https://doi.org/10.1038/nm.1935	journal	February 2009
The other Janus face of Qa-1 and HLA-E: diverse peptide repertoires in times of stress van Hall, Thorbald; Oliveira, Claudia C.; Joosten, Simone A. Microbes and Infection, Vol. 12, Issue 12-13 https://doi.org/10.1016/j.micinf.2010.07.011	journal	November 2010
Sub-angstrom modeling of complexes between flexible peptides and globular proteins Raveh, Barak; London, Nir; Schueler-Furman, Ora Proteins: Structure, Function, and Bioinformatics https://doi.org/10.1002/prot.22716	journal	January 2010
Towards a systems understanding of MHC class I and MHC class II antigen presentation Neefjes, Jacques; Jongsma, Marlieke L. M.; Paul, Petra Nature Reviews Immunology, Vol. 11, Issue 12 https://doi.org/10.1038/nri3084	journal	November 2011
Improved side-chain torsion potentials for the Amber ff99SB protein force field Lindorff-Larsen, Kresten; Piana, Stefano; Palmo, Kim Proteins: Structure, Function, and Bioinformatics https://doi.org/10.1002/prot.22711	journal	January 2010
Activating CD94:NKG2C and inhibitory CD94:NKG2A receptors are expressed by distinct subsets of committed CD8+ TCR ?? lymphocytes Arlettaz, Lionel; Villard, Jean; de Rham, Casimir European Journal of Immunology, Vol. 34, Issue 12 https://doi.org/10.1002/eji.200425210	journal	December 2004
The HLA-A2 Restricted T Cell Epitope HCV Core35–44 Stabilizes HLA-E Expression and Inhibits Cytolysis Mediated by Natural Killer Cells Nattermann, Jacob; Nischalke, Hans Dieter; Hofmeister, Valeska The American Journal of Pathology, Vol. 166, Issue 2 https://doi.org/10.1016/S0002-9440(10)62267-5	journal	February 2005
Human CD8 T lymphocytes recognize Mycobacterium tuberculosis antigens presented by HLA-E during active tuberculosis and express type 2 cytokines : Immunity to infection Caccamo, Nadia; Pietra, Gabriella; Sullivan, Lucy C. European Journal of Immunology, Vol. 45, Issue 4 https://doi.org/10.1002/eji.201445193	journal	February 2015
A highly sensitive selection method for directed evolution of homing endonucleases Chen, Z. Nucleic Acids Research, Vol. 33, Issue 18 https://doi.org/10.1093/nar/gni148	journal	October 2005
Impact of MHC class I diversity on immune control of immunodeficiency virus replication Goulder, Philip J. R.; Watkins, David I. Nature Reviews Immunology, Vol. 8, Issue 8 https://doi.org/10.1038/nri2357	journal	August 2008
P-LINCS: A Parallel Linear Constraint Solver for Molecular Simulation Hess, Berk Journal of Chemical Theory and Computation, Vol. 4, Issue 1 https://doi.org/10.1021/ct700200b	journal	December 2007
Confronting Complexity: Real-World Immunodominance in Antiviral CD8+ T Cell Responses Yewdell, Jonathan W. Immunity, Vol. 25, Issue 4 https://doi.org/10.1016/j.immuni.2006.09.005	journal	October 2006
Composition Profiler: a tool for discovery and visualization of amino acid composition differences Vacic, Vladimir; Uversky, Vladimir N.; Dunker, A. Keith BMC Bioinformatics, Vol. 8, Issue 1 https://doi.org/10.1186/1471-2105-8-211	journal	January 2007
Cutting Edge: The Human Cytomegalovirus UL40 Gene Product Contains a Ligand for HLA-E and Prevents NK Cell-Mediated Lysis Ulbrecht, Matthias; Martinozzi, Silvia; Grzeschik, Mariola The Journal of Immunology, Vol. 164, Issue 10 https://doi.org/10.4049/jimmunol.164.10.5019	journal	May 2000
GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit Pronk, Sander; Páll, Szilárd; Schulz, Roland Bioinformatics, Vol. 29, Issue 7 https://doi.org/10.1093/bioinformatics/btt055	journal	February 2013
Gag-Specific CD8 ⁺ T Lymphocytes Recognize Infected Cells before AIDS-Virus Integration and Viral Protein Expression Sacha, Jonah B.; Chung, Chungwon; Rakasz, Eva G. The Journal of Immunology, Vol. 178, Issue 5 https://doi.org/10.4049/jimmunol.178.5.2746	journal	February 2007
Comparative Protein Structure Modeling Using MODELLER Webb, Benjamin; Sali, Andrej Current Protocols in Bioinformatics, Vol. 47, Issue 1 https://doi.org/10.1002/0471250953.bi0506s47	journal	September 2014
Epock: rapid analysis of protein pocket dynamics Laurent, Benoist; Chavent, Matthieu; Cragnolini, Tristan Bioinformatics, Vol. 31, Issue 9 https://doi.org/10.1093/bioinformatics/btu822	journal	December 2014
A new method for predicting binding affinity in computer-aided drug design Åqvist, Johan; Medina, Carmen; Samuelsson, Jan-Erik "Protein Engineering, Design and Selection", Vol. 7, Issue 3 https://doi.org/10.1093/protein/7.3.385	journal	January 1994
Alternative peptide repertoire of HLA-E reveals a binding motif that is strikingly similar to HLA-A2 Lampen, Margit H.; Hassan, Chopie; Sluijter, Marjolein Molecular Immunology, Vol. 53, Issue 1-2 https://doi.org/10.1016/j.molimm.2012.07.009	journal	January 2013
The major histocompatibility complex class Ib molecule HLA-E at the interface between innate and adaptive immunity Sullivan, L. C.; Clements, C. S.; Rossjohn, J. Tissue Antigens, Vol. 72, Issue 5 https://doi.org/10.1111/j.1399-0039.2008.01138.x	journal	November 2008
Major histocompatibility complex genotyping with massively parallel pyrosequencing Wiseman, Roger W.; Karl, Julie A.; Bimber, Benjamin N. Nature Medicine, Vol. 15, Issue 11 https://doi.org/10.1038/nm.2038	journal	October 2009
Regulation and trafficking of the HLA-E molecules during monocyte-macrophage differentiation Camilli, Giorgio; Cassotta, Antonino; Battella, Simone Journal of Leukocyte Biology, Vol. 99, Issue 1 https://doi.org/10.1189/jlb.1A0415-172R	journal	August 2015
WebLogo: A Sequence Logo Generator Crooks, Gavin E.; Hon, Gary; Chandonia, John-Marc Genome Research, Vol. 14, Issue 6, p. 1188-1190 https://doi.org/10.1101/gr.849004	journal	May 2004
Simple and highly efficient BAC recombineering using galK selection Warming, S. Nucleic Acids Research, Vol. 33, Issue 4 https://doi.org/10.1093/nar/gni035	journal	February 2005
HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C Braud, Veronique M.; Allan, David S. J.; O'Callaghan, Christopher A. Nature, Vol. 391, Issue 6669 https://doi.org/10.1038/35869	journal	February 1998
HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A Lee, N.; Llano, M.; Carretero, M. Proceedings of the National Academy of Sciences, Vol. 95, Issue 9 https://doi.org/10.1073/pnas.95.9.5199	journal	April 1998
Clinical and immunological significance of HLA-E in stem cell transplantation and cancer: HLA-E in transplantation and cancer Wieten, L.; Mahaweni, N. M.; Voorter, C. E. M. Tissue Antigens, Vol. 84, Issue 6 https://doi.org/10.1111/tan.12478	journal	November 2014
Basic and translational applications of engineered MHC class I proteins Hansen, Ted H.; Connolly, Janet M.; Gould, Keith G. Trends in Immunology, Vol. 31, Issue 10 https://doi.org/10.1016/j.it.2010.07.003	journal	October 2010
The Mycobacterium tuberculosis Phagosome Is a HLA-I Processing Competent Organelle Grotzke, Jeff E.; Harriff, Melanie J.; Siler, Anne C. PLoS Pathogens, Vol. 5, Issue 4 https://doi.org/10.1371/journal.ppat.1000374	journal	April 2009
The Cytoplasmic Domain of Rhesus Cytomegalovirus Rh178 Interrupts Translation of Major Histocompatibility Class I Leader Peptide-Containing Proteins prior to Translocation Richards, R.; Scholz, I.; Powers, C. Journal of Virology, Vol. 85, Issue 17 https://doi.org/10.1128/JVI.05021-11	journal	June 2011
Analysis of HLA-E Peptide-Binding Specificity and Contact Residues in Bound Peptide Required for Recognition by CD94/NKG2 Miller, Joseph D.; Weber, Dominique A.; Ibegbu, Chris The Journal of Immunology, Vol. 171, Issue 3 https://doi.org/10.4049/jimmunol.171.3.1369	journal	July 2003
Human Cytomegalovirus UL40 Signal Peptide Regulates Cell Surface Expression of the NK Cell Ligands HLA-E and gpUL18 Prod’homme, Virginie; Tomasec, Peter; Cunningham, Charles The Journal of Immunology, Vol. 188, Issue 6 https://doi.org/10.4049/jimmunol.1102068	journal	February 2012
Rosetta FlexPepDock web server—high resolution modeling of peptide–protein interactions London, Nir; Raveh, Barak; Cohen, Eyal Nucleic Acids Research, Vol. 39, Issue suppl_2 https://doi.org/10.1093/nar/gkr431	journal	May 2011
Molecular dynamics with coupling to an external bath Berendsen, H. J. C.; Postma, J. P. M.; van Gunsteren, W. F. The Journal of Chemical Physics, Vol. 81, Issue 8 https://doi.org/10.1063/1.448118	journal	October 1984
The Emerging Role of HLA-E-Restricted CD8 ⁺ T Lymphocytes in the Adaptive Immune Response to Pathogens and Tumors Pietra, Gabriella; Romagnani, Chiara; Manzini, Claudia Journal of Biomedicine and Biotechnology, Vol. 2010 https://doi.org/10.1155/2010/907092	journal	January 2010
Subangstrom Accuracy in pHLA-I Modeling by Rosetta FlexPepDock Refinement Protocol Liu, Tengfei; Pan, Xianchao; Chao, Li Journal of Chemical Information and Modeling, Vol. 54, Issue 8 https://doi.org/10.1021/ci500393h	journal	July 2014
Rapid modification of bacterial artificial chromosomes by ET- recombination Muyrers, J. Nucleic Acids Research, Vol. 27, Issue 6 https://doi.org/10.1093/nar/27.6.1555	journal	March 1999
Establishment of a quantitative ELISA capable of determining peptide - MHC class I interaction Sylvester-Hvid, C.; Kristensen, N.; Blicher, T. Tissue Antigens, Vol. 59, Issue 4 https://doi.org/10.1034/j.1399-0039.2002.590402.x	journal	April 2002
New Paradigms for HIV/AIDS Vaccine Development Picker, Louis J.; Hansen, Scott G.; Lifson, Jeffrey D. Annual Review of Medicine, Vol. 63, Issue 1 https://doi.org/10.1146/annurev-med-042010-085643	journal	February 2012
Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine Hansen, Scott G.; Ford, Julia C.; Lewis, Matthew S. Nature, Vol. 473, Issue 7348 https://doi.org/10.1038/nature10003	journal	May 2011
What determines the van der Waals coefficient ? in the LIE (linear interaction energy) method to estimate binding free energies using molecular dynamics simulations? Wang, Wei; Wang, Jian; Kollman, Peter A. Proteins: Structure, Function, and Genetics, Vol. 34, Issue 3 https://doi.org/10.1002/(SICI)1097-0134(19990215)34:3<395::AID-PROT11>3.0.CO;2-4	journal	February 1999
A smooth particle mesh Ewald method Essmann, Ulrich; Perera, Lalith; Berkowitz, Max L. The Journal of Chemical Physics, Vol. 103, Issue 19 https://doi.org/10.1063/1.470117	journal	November 1995
The role of mhc polymorphism in anti-microbial resistance Nikolich-Zugich, J. Microbes and Infection, Vol. 6, Issue 5 https://doi.org/10.1016/j.micinf.2004.01.006	journal	April 2004
HLA-E Allelic Variants: CORRELATING DIFFERENTIAL EXPRESSION, PEPTIDE AFFINITIES, CRYSTAL STRUCTURES, AND THERMAL STABILITIES Strong, Roland K.; Holmes, Margaret A.; Li, Pingwei Journal of Biological Chemistry, Vol. 278, Issue 7 https://doi.org/10.1074/jbc.M208268200	journal	October 2002
Efficient replication of rhesus cytomegalovirus variants in multiple rhesus and human cell types Lilja, A. E.; Shenk, T. Proceedings of the National Academy of Sciences, Vol. 105, Issue 50 https://doi.org/10.1073/pnas.0811063106	journal	December 2008

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59 BASIC BIOLOGICAL SCIENCES
Biological Science
CD8+ T
Major histocompatibility complex E
MHC-E
HIV

Title: Broadly targeted CD8+ T cell responses restricted by major histocompatibility complex E

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