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Title: Dynamic structures in DNA damage responses & cancer

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Journal Article: Published Article
Journal Name:
Progress in Biophysics and Molecular Biology
Additional Journal Information:
Journal Volume: 117; Journal Issue: 2-3; Related Information: CHORUS Timestamp: 2016-09-04 19:21:22; Journal ID: ISSN 0079-6107
Country of Publication:
United Kingdom

Citation Formats

Tainer, John A. Dynamic structures in DNA damage responses & cancer. United Kingdom: N. p., 2015. Web. doi:10.1016/j.pbiomolbio.2015.04.003.
Tainer, John A. Dynamic structures in DNA damage responses & cancer. United Kingdom. doi:10.1016/j.pbiomolbio.2015.04.003.
Tainer, John A. 2015. "Dynamic structures in DNA damage responses & cancer". United Kingdom. doi:10.1016/j.pbiomolbio.2015.04.003.
title = {Dynamic structures in DNA damage responses & cancer},
author = {Tainer, John A.},
abstractNote = {},
doi = {10.1016/j.pbiomolbio.2015.04.003},
journal = {Progress in Biophysics and Molecular Biology},
number = 2-3,
volume = 117,
place = {United Kingdom},
year = 2015,
month = 3

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record at 10.1016/j.pbiomolbio.2015.04.003

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  • The aim of this paper is to investigate what safety factor might exist between the results of conventional linear calculations referring to the regulatory definitions of ultimate conditions and the results of computation using nonlinear laws to describe the behavior of materials. The effects of seismic excitation on a reinforced concrete beam have been studied on the shaking table Vesuve in Saclay. Pure flexural behavior tests, up to rupture, have been performed. Analytical models describing the behavior of reinforced concrete were worked out, particularly for the region where the concrete is widely cracked whereas the reinforcement still remains elastic. Aftermore » comparison of the experimental data with the results of a conventional elastic analysis, significantly higher safety factors have been derived, thus allowing a more realistic analysis of nuclear structures. 4 refs.« less
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  • Human anti-murine antibody (HAMA) responses were monitored in 23 patients with recurrent or persistent epithelial ovarian carcinoma undergoing single-dose intraperitoneal radioimmunotherapy (RIT) with the murine monoclonal antibody OC-125. Sera of patients receiving escalating doses of OC-125 F(ab')2 (10-70 mg) radiolabeled with 18 to 141 mCi of iodine-131 were assayed for HAMA by a protein A-based radioimmunoassay. Overall, 70% of patients (16/23) developed HAMA within 10 to 46 days (median = 29) postinfusion, with peak values (23 +/- 6 to 325 +/- 10 micrograms/ml) at 32 to 102 days (median = 38). HAMA was undetectable prior to infusion in all casesmore » and persisted up to 76 weeks. Of patients receiving a dose of 123 mCi or less, 80% (16/20) developed HAMA, whereas in the 140-mCi group, none of the three patients had detectable levels. Two patients in the 140-mCi group demonstrated dose-limiting bone marrow toxicity (severe thrombocytopenia and neutropenia). It is concluded that a single intraperitoneal dose of monoclonal antibody leads to a high incidence of HAMA production. The results also suggest that the likelihood of HAMA formation in patients who either had undergone recent chemotherapy or had received the highest dose of the radioimmunoconjugate is reduced. These observations may be of significance in designing multiple-dose therapy trials as HAMA has been demonstrated to decrease antibody-to-tumor binding and may potentially increase renal, hepatic, and hematologic toxicity associated with radioimmunotherapy.« less
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