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Title: Nanoscale materials for hyperthermal theranostics

Journal Article · · Nanoscale
DOI:https://doi.org/10.1039/c4nr06164k· OSTI ID:1287495
 [1];  [2];  [3];  [4]
  1. Univ. of Washington, Seattle, WA (United States). Dept. of Chemistry
  2. Univ. of Washington, Seattle, WA (United States). Material Science & Engineering Dept.
  3. Univ. of Washington, Seattle, WA (United States). Material Science & Engineering Dept
  4. Univ. of Washington, Seattle, WA (United States). Material Science & Engineering Dept; Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Fundamental & Computational Sciences Directorate

Recently, the use of nanoscale materials has attracted considerable attention with the aim of designing personalized therapeutic approaches that can enhance both spatial and temporal control over drug release, permeability, and uptake. Potential benefits to patients include the reduction of overall drug dosages, enabling the parallel delivery of different pharmaceuticals, and the possibility of enabling additional functionalities such as hyperthermia or deep-tissue imaging (LIF, PET, etc.) that complement and extend the efficacy of traditional chemotherapy and surgery. Our mini review is focused on an emerging class of nanometer-scale materials that can be used both to heat malignant tissue to reduce angiogenesis and DNA-repair while simultaneously offering complementary imaging capabilities based on radioemission, optical fluorescence, magnetic resonance, and photoacoustic methods.

Research Organization:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Sponsoring Organization:
USDOE; US Air Force Office of Scientific Research (AFOSR)
Grant/Contract Number:
AC06-76RL01830; DGE-1256082; FA95501210400
OSTI ID:
1287495
Journal Information:
Nanoscale, Vol. 7, Issue 16; ISSN 2040-3364
Publisher:
Royal Society of ChemistryCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 39 works
Citation information provided by
Web of Science

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  • Durr, Nicholas J.; Larson, Timothy; Smith, Daniel K.
  • Frontiers in Optics 2007/Laser Science XXIII/Organic Materials and Devices for Displays and Energy Conversion https://doi.org/10.1364/fio.2007.ftuo5
conference January 2007
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