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Title: Nanoscale pillar arrays for separations

Abstract

The work presented herein evaluates silicon nano-pillar arrays for use in planar chromatography. Electron beam lithography and metal thermal dewetting protocols were used to create nano-thin layer chromatography platforms. With these fabrication methods we are able to reduce the size of the characteristic features in a separation medium below that used in ultra-thin layer chromatography; i.e. pillar heights are 1-2μm and pillar diameters are typically in the 200- 400nm range. In addition to the intrinsic nanoscale aspects of the systems, it is shown they can be further functionalized with nanoporous layers and traditional stationary phases for chromatography; hence exhibit broad-ranging lab-on-a-chip and point-of-care potential. Because of an inherent high permeability and very small effective mass transfer distance between pillars, chromatographic efficiency can be very high but is enhanced herein by stacking during development and focusing while drying, yielding plate heights in the nm range separated band volumes. Practical separations of fluorescent dyes, fluorescently derivatized amines, and anti-tumor drugs are illustrated.

Authors:
 [1];  [1];  [1];  [2];  [3];  [3];  [3]
  1. Univ. of Tennessee, Knoxville, TN (United States)
  2. Univ. of Tennessee, Knoxville, TN (United States); Y-12 National Security Complex, Oak Ridge, TN (United States)
  3. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Publication Date:
Research Org.:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Sciences (CNMS)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
1265739
Grant/Contract Number:
AC05-00OR22725
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Analyst
Additional Journal Information:
Journal Volume: 140; Journal Issue: 10; Journal ID: ISSN 0003-2654
Publisher:
Royal Society of Chemistry
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Kirchner, Teresa, Strickhouser, Rachel, Hatab, Nahla, Charlton, Jennifer, Kravchenko, Ivan I., Lavrik, Nickolay V., and Sepaniak, Michael J. Nanoscale pillar arrays for separations. United States: N. p., 2015. Web. doi:10.1039/C4AN02187H.
Kirchner, Teresa, Strickhouser, Rachel, Hatab, Nahla, Charlton, Jennifer, Kravchenko, Ivan I., Lavrik, Nickolay V., & Sepaniak, Michael J. Nanoscale pillar arrays for separations. United States. doi:10.1039/C4AN02187H.
Kirchner, Teresa, Strickhouser, Rachel, Hatab, Nahla, Charlton, Jennifer, Kravchenko, Ivan I., Lavrik, Nickolay V., and Sepaniak, Michael J. Wed . "Nanoscale pillar arrays for separations". United States. doi:10.1039/C4AN02187H. https://www.osti.gov/servlets/purl/1265739.
@article{osti_1265739,
title = {Nanoscale pillar arrays for separations},
author = {Kirchner, Teresa and Strickhouser, Rachel and Hatab, Nahla and Charlton, Jennifer and Kravchenko, Ivan I. and Lavrik, Nickolay V. and Sepaniak, Michael J.},
abstractNote = {The work presented herein evaluates silicon nano-pillar arrays for use in planar chromatography. Electron beam lithography and metal thermal dewetting protocols were used to create nano-thin layer chromatography platforms. With these fabrication methods we are able to reduce the size of the characteristic features in a separation medium below that used in ultra-thin layer chromatography; i.e. pillar heights are 1-2μm and pillar diameters are typically in the 200- 400nm range. In addition to the intrinsic nanoscale aspects of the systems, it is shown they can be further functionalized with nanoporous layers and traditional stationary phases for chromatography; hence exhibit broad-ranging lab-on-a-chip and point-of-care potential. Because of an inherent high permeability and very small effective mass transfer distance between pillars, chromatographic efficiency can be very high but is enhanced herein by stacking during development and focusing while drying, yielding plate heights in the nm range separated band volumes. Practical separations of fluorescent dyes, fluorescently derivatized amines, and anti-tumor drugs are illustrated.},
doi = {10.1039/C4AN02187H},
journal = {Analyst},
number = 10,
volume = 140,
place = {United States},
year = {Wed Apr 01 00:00:00 EDT 2015},
month = {Wed Apr 01 00:00:00 EDT 2015}
}

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Cited by: 8 works
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