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Title: 2,2'-Bis(monoacylglycero) PO 4 (BMP), but Not 3,1'-BMP, Increases Membrane Curvature Stress to Enhance α-Tocopherol Transfer Protein Binding to Membranes

Abstract

Previous work revealed that α-tocopherol transfer protein (α-TTP) co-localizes with bis(monoacylglycero)phosphate (BMP) in late endosomes. BMP is a lipid unique to late endosomes and is believed to induce membrane curvature and support the multivesicular nature of this organelle. In this paper, we examined the effect of BMP on α-TTP binding to membranes using dual polarization interferometry and vesicle-binding assay. α-TTP binding to membranes is increased by the curvature-inducing lipid BMP. Finally, α-TTP binds to membranes with greater affinity when they contain the 2,2'-BMP versus 3,1'-BMP isomers.

Authors:
 [1];  [1];  [2];  [2];  [1]
  1. Brock Univ., St. Catharines, ON (Canada). Chemistry and Centre for Biotechnology
  2. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
OSTI Identifier:
1265511
DOE Contract Number:  
AC05-00OR2275; FG02-08ER46528
Resource Type:
Journal Article
Resource Relation:
Journal Name: Lipids; Journal Volume: 50; Journal Issue: 3
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Baptist, Matilda, Panagabko, Candace, Nickels, Jonathan D., Katsaras, John, and Atkinson, Jeffrey. 2,2'-Bis(monoacylglycero) PO4 (BMP), but Not 3,1'-BMP, Increases Membrane Curvature Stress to Enhance α-Tocopherol Transfer Protein Binding to Membranes. United States: N. p., 2015. Web. doi:10.1007/s11745-015-3989-9.
Baptist, Matilda, Panagabko, Candace, Nickels, Jonathan D., Katsaras, John, & Atkinson, Jeffrey. 2,2'-Bis(monoacylglycero) PO4 (BMP), but Not 3,1'-BMP, Increases Membrane Curvature Stress to Enhance α-Tocopherol Transfer Protein Binding to Membranes. United States. doi:10.1007/s11745-015-3989-9.
Baptist, Matilda, Panagabko, Candace, Nickels, Jonathan D., Katsaras, John, and Atkinson, Jeffrey. Wed . "2,2'-Bis(monoacylglycero) PO4 (BMP), but Not 3,1'-BMP, Increases Membrane Curvature Stress to Enhance α-Tocopherol Transfer Protein Binding to Membranes". United States. doi:10.1007/s11745-015-3989-9.
@article{osti_1265511,
title = {2,2'-Bis(monoacylglycero) PO4 (BMP), but Not 3,1'-BMP, Increases Membrane Curvature Stress to Enhance α-Tocopherol Transfer Protein Binding to Membranes},
author = {Baptist, Matilda and Panagabko, Candace and Nickels, Jonathan D. and Katsaras, John and Atkinson, Jeffrey},
abstractNote = {Previous work revealed that α-tocopherol transfer protein (α-TTP) co-localizes with bis(monoacylglycero)phosphate (BMP) in late endosomes. BMP is a lipid unique to late endosomes and is believed to induce membrane curvature and support the multivesicular nature of this organelle. In this paper, we examined the effect of BMP on α-TTP binding to membranes using dual polarization interferometry and vesicle-binding assay. α-TTP binding to membranes is increased by the curvature-inducing lipid BMP. Finally, α-TTP binds to membranes with greater affinity when they contain the 2,2'-BMP versus 3,1'-BMP isomers.},
doi = {10.1007/s11745-015-3989-9},
journal = {Lipids},
number = 3,
volume = 50,
place = {United States},
year = {Wed Jan 21 00:00:00 EST 2015},
month = {Wed Jan 21 00:00:00 EST 2015}
}