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Title: Commentary on Inhaled 239PuO 2 in Dogs — A Prophylaxis against Lung Cancer?

Abstract

Several studies on the effect of inhaled plutonium-dioxide particulates and the incidence of lung tumors in dogs reveal beneficial effects when the cumulative alpha-radiation dose is low. There is a threshold at an exposure level of about 100 cGy for excess tumor incidence and reduced lifespan. The observations conform to the expectations of the radiation hormesis dose-response model and contradict the predictions of the LNT hypothesis. These studies suggest investigating the possibility of employing low-dose alpha-radiation, such as from 239PuO 2 inhalation, as a prophylaxis against lung cancer.

Authors:
 [1];  [2]
  1. Cuttler & Associates, Vaughan, ON (Canada)
  2. Brookhaven National Lab. (BNL), Upton, NY (United States)
Publication Date:
Research Org.:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1263484
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Dose-Response
Additional Journal Information:
Journal Volume: 13; Journal Issue: -1; Journal ID: ISSN 1559-3258
Publisher:
International Hormesis Society
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; plutonium-dioxide; inhalation; lung cancer; prophylaxis; radiation hormesis; adaptive protection

Citation Formats

Cuttler, Jerry M., and Feinendegen, Ludwig E. Commentary on Inhaled 239PuO2 in Dogs — A Prophylaxis against Lung Cancer?. United States: N. p., 2015. Web. doi:10.2203/dose-response.15-003.Cuttler.
Cuttler, Jerry M., & Feinendegen, Ludwig E. Commentary on Inhaled 239PuO2 in Dogs — A Prophylaxis against Lung Cancer?. United States. doi:10.2203/dose-response.15-003.Cuttler.
Cuttler, Jerry M., and Feinendegen, Ludwig E. Thu . "Commentary on Inhaled 239PuO2 in Dogs — A Prophylaxis against Lung Cancer?". United States. doi:10.2203/dose-response.15-003.Cuttler. https://www.osti.gov/servlets/purl/1263484.
@article{osti_1263484,
title = {Commentary on Inhaled 239PuO2 in Dogs — A Prophylaxis against Lung Cancer?},
author = {Cuttler, Jerry M. and Feinendegen, Ludwig E.},
abstractNote = {Several studies on the effect of inhaled plutonium-dioxide particulates and the incidence of lung tumors in dogs reveal beneficial effects when the cumulative alpha-radiation dose is low. There is a threshold at an exposure level of about 100 cGy for excess tumor incidence and reduced lifespan. The observations conform to the expectations of the radiation hormesis dose-response model and contradict the predictions of the LNT hypothesis. These studies suggest investigating the possibility of employing low-dose alpha-radiation, such as from 239PuO2 inhalation, as a prophylaxis against lung cancer.},
doi = {10.2203/dose-response.15-003.Cuttler},
journal = {Dose-Response},
number = -1,
volume = 13,
place = {United States},
year = {Thu Jan 01 00:00:00 EST 2015},
month = {Thu Jan 01 00:00:00 EST 2015}
}

Journal Article:
Free Publicly Available Full Text
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