Alteration and modulation of protein activity by varying post-translational modification

Thompson, David N.; Reed, David W.; Thompson, Vicki S.; Lacey, Jeffrey A.; Apel, William A.

Alteration and modulation of protein activity by varying post-translational modification

Patent · 12 July 2016

OSTI ID:1261626

Thompson, David N.; Reed, David W.; Thompson, Vicki S.; Lacey, Jeffrey A.; Apel, William A.

Embodiments of the invention include methods of altering the enzymatic activity or solubility of an extremophilic enzyme or post-translationally modifying a protein of interest via using isolated or partially purified glycosyltransferases and/or post-translational modification proteins, extracts of cells comprising glycosyltransferases and/or post-translational modification proteins, and/or in cells comprising one or more glycosyltransferases and/or post-translational modification proteins.

View Patent

Research Organization:: Idaho National Laboratory (INL), Idaho Falls, ID (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC07-99ID13727; AC07-05ID14517

Assignee:: Battelle Energy Alliance, LLC (Idaho Falls, ID)

Patent Number(s):: 9,388,398

Application Number:: 14/632,770

OSTI ID:: 1261626

Country of Publication:: United States

Language:: English

References (60)

Crystallographic and mutational analyses of an extremely acidophilic and acid-stable xylanase: biased distribution of acidic residues and importance of Asp37 for catalysis at low pH Fushinobu, S.; Ito, K.; Konno, M. Protein Engineering Design and Selection, Vol. 11, Issue 12, p. 1121-1128 https://doi.org/10.1093/protein/11.12.1121	journal	December 1998
Baculovirus systems for the expression of human gene products Luckow, Verne A. Current Opinion in Biotechnology, Vol. 4, Issue 5, p. 564-572 https://doi.org/10.1016/0958-1669(93)90078-B	journal	October 1993
Cellulase-free xylanases from Bacillus and other microorganisms Subramaniyan, S.; Prema, P. FEMS Microbiology Letters, Vol. 183, Issue 1, p. 1-7 https://doi.org/10.1111/j.1574-6968.2000.tb08925.x	journal	February 2000
An extremely thermostable xylanase from the thermophilic eubacterium Thermotoga Simpson, H D; Haufler, U R; Daniel, R M Biochemical Journal, Vol. 277, Issue 2, p. 413-417 https://doi.org/10.1042/bj2770413	journal	July 1991
Molecular diversity of thermophilic cellulolytic and hemicellulolytic bacteria Bergquist, Peter L.; Gibbs, Moreland D.; Morris, Daniel D. FEMS Microbiology Ecology, Vol. 28, Issue 2, p. 99-110 https://doi.org/10.1111/j.1574-6941.1999.tb00565.x	journal	February 1999
Specificity of the protein secretory apparatus: secretion of the heat-labile enterotoxin B subunit pentamers by different species of Gram- bacteria Michel, Linda Overbye; Sandkvist, Maria; Bagdasarian, Michael Gene, Vol. 152, Issue 1, p. 41-45 https://doi.org/10.1016/0378-1119(94)00691-K	journal	January 1995
Glycosyl hydrolases from hyperthermophiles Sunna, Anwar; Moracci, Marco; Rossi, Mose Extremophiles, Vol. 1, Issue 1, p. 2-13 https://doi.org/10.1007/s007920050009	journal	February 1997
The first description of an archaeal hemicellulase: the xylanase from Thermococcus zilligii strain AN1 Uhl, Andreas M.; Daniel, Roy M. Extremophiles, Vol. 3, Issue 4, p. 263-267 https://doi.org/10.1007/s007920050126	journal	November 1999
Development of gas phase bioreactors for the removal of nitrogen oxides from synthetic flue gas streams Flanagan, William P.; Apel, William A.; Barnes, Joni M. Fuel, Vol. 81, Issue 15, p. 1953-1961 https://doi.org/10.1016/S0016-2361(02)00130-8	journal	October 2002
Measurement of fumonisins in corn with a fiber optic fluoroimmunosensor Thompson, Vicki S.; Maragos, Chris M.; Thompson, Richard B. Advances in Fluorescence Sensing Technology III, Vol. 2980 https://doi.org/10.1117/12.273560	conference	May 1997
PCR ligation mutagenesis in transformable streptococci: application and efficiency Lau, Peter C. Y.; Sung, Chang Kyoo; Lee, Janet H. Journal of Microbiological Methods, Vol. 49, Issue 2, p. 193-205 https://doi.org/10.1016/S0167-7012(01)00369-4	journal	April 2002
Conversion of a β-Ketoacyl Synthase to a Malonyl Decarboxylase by Replacement of the Active-Site Cysteine with Glutamine Witkowski, Andrzej; Joshi, Anil K.; Lindqvist, Ylva Biochemistry, Vol. 38, Issue 36, p. 11643-11650 https://doi.org/10.1021/bi990993h	journal	September 1999
Kenealy, William R.; Jeffries, Thomas W. Biotechnology Letters, Vol. 25, Issue 19, p. 1619-1623 https://doi.org/10.1023/A:1025668031928	journal	October 2003
Crystal structures of the effector-binding domain of repressor Central glycolytic gene Regulator from Bacillus subtilis reveal ligand-induced structural changes upon binding of several glycolytic intermediates Řezáčová, Pavlína; Kožíšek, Milan; Moy, Shiu F. Molecular Microbiology, Vol. 69, Issue 4, p. 895-910 https://doi.org/10.1111/j.1365-2958.2008.06318.x	journal	August 2008
Maltose and Maltodextrin Transport in the Thermoacidophilic Gram-Positive Bacterium Alicyclobacillus acidocaldarius Is Mediated by a High-Affinity Transport System That Includes a Maltose Binding Protein Tolerant to Low pH Hülsmann, A.; Lurz, R.; Scheffel, F. Journal of Bacteriology, Vol. 182, Issue 22, p. 6292-6301 https://doi.org/10.1128/JB.182.22.6292-6301.2000	journal	November 2000
Functional reconstitution of a maltose ATP-binding cassette transporter from the thermoacidophilic gram-positive bacterium Alicyclobacillus acidocaldarius Scheffel, Frank; Fleischer, Rebecca; Schneider, Erwin Biochimica et Biophysica Acta (BBA) - Bioenergetics, Vol. 1656, Issue 1, p. 57-65 https://doi.org/10.1016/j.bbabio.2004.01.005	journal	May 2004
Dilute-Sulfuric Acid Pretreatment of Corn Stover in Pilot-Scale Reactor Schell, Daniel J.; Farmer, Jody; Newman, Millie Biotechnology for Fuels and Chemicals https://doi.org/10.1007/978-1-4612-0057-4_6	book	January 2003
The acid hydrolysis of sugarcane bagasse hemicellulose to produce xylose, arabinose, glucose and other products Lavarack, B. P.; Griffin, G. J.; Rodman, D. Biomass and Bioenergy, Vol. 23, Issue 5, p. 367-380 https://doi.org/10.1016/S0961-9534(02)00066-1	journal	November 2002
Gene cloning, sequencing, and characterization of a family 9 endoglucanase (CelA) with an unusual pattern of activity from the thermoacidophile Alicyclobacillus acidocaldarius ATCC27009 K., Eckert; F., Zielinski; Leggio, L. Lo Applied Microbiology and Biotechnology, Vol. 60, Issue 4, p. 428-436 https://doi.org/10.1007/s00253-002-1131-4	journal	December 2002
Comparison of pretreatment methods on the basis of available surface area Thompson, David N.; Chen, Hsin-Chih; Grethlein, Hans E. Bioresource Technology, Vol. 39, Issue 2, p. 155-163 https://doi.org/10.1016/0960-8524(92)90135-K	journal	January 1992
A new class of biodegradable materials: Poly-3-hydroxy-butyrate/steam exploded straw fiber composites. I. Thermal and impact behavior Avella, Maurizio; Martuscelli, Ezio; Pascucci, Beniamino Journal of Applied Polymer Science, Vol. 49, Issue 12, p. 2091-2103 https://doi.org/10.1002/app.1993.070491205	journal	September 1993
Two Glyceraldehyde-3-phosphate Dehydrogenases with Opposite Physiological Roles in a Nonphotosynthetic Bacterium Fillinger, Sabine; Boschi-Muller, Sandrine; Azza, Saı̈d Journal of Biological Chemistry, Vol. 275, Issue 19, p. 14031-14037 https://doi.org/10.1074/jbc.275.19.14031	journal	May 2000
Microbial Pretreatment of Biomass: Potential for Reducing Severity of Thermochemical Biomass Pretreatment Keller, Fred A.; Hamilton, Jenny E.; Nguyen, Quang A. Applied Biochemistry and Biotechnology, Vol. 105, Issue 1-3, p. 27-42 https://doi.org/10.1385/ABAB:105:1-3:27	journal	January 2003
Production of a cellulase-free xylanase from agricultural waste materials by a thermotolerant Streptomyces sp. Techapun, Charin; Sinsuwongwat, Suphawat; Poosaran, Naiyatat Biotechnology Letters, Vol. 23, Issue 20, p. 1685-1689 https://doi.org/10.1023/A:1012448229555	journal	October 2001
Characterization of a new bacteriophage which infects bacteria of the genus Acidiphilium Ward, T. E.; Bruhn, D. F.; Shean, M. L. Journal of General Virology, Vol. 74, Issue 11, p. 2419-2425 https://doi.org/10.1099/0022-1317-74-11-2419	journal	November 1993
Rapid production of thermostable cellulase-free xylanase by a strain of Bacillus subtilis and its properties Sá-Pereira, Paula; Mesquita, Alexandra; Duarte, José C. Enzyme and Microbial Technology, Vol. 30, Issue 7, p. 924-933 https://doi.org/10.1016/S0141-0229(02)00034-0	journal	June 2002
Prediction of protein function from protein sequence and structure Whisstock, James C.; Lesk, Arthur M. Quarterly Reviews of Biophysics, Vol. 36, Issue 3, p. 307-340 https://doi.org/10.1017/S0033583503003901	journal	January 1999
Dilute Acid Pretreatment, Enzymatic Saccharification, and Fermentation of Rice Hulls to Ethanol Saha, Badal C.; Iten, Loren B.; Cotta, Michael A. Biotechnology Progress, Vol. 21, Issue 3, p. 816-822 https://doi.org/10.1021/bp049564n	journal	January 2005
In vitro degradation of natural insoluble lignin in aqueous media by the extracellular peroxidases of Phanerochaete chrysosporium Thompson, David N.; Hames, Bonnie R.; Reddy, C. Adinarayana Biotechnology and Bioengineering, Vol. 57, Issue 6, p. 704-717 https://doi.org/10.1002/(SICI)1097-0290(19980320)57:6<704::AID-BIT8>3.0.CO;2-P	journal	March 1998
Simultaneous saccharification and fermentation of cellulose: Effect of ethanol on enzymatic saccharification of cellulose Ooshima, Hiroshi; Ishitani, Yohsuke; Harano, Yoshio Biotechnology and Bioengineering, Vol. 27, Issue 4, p. 389-397 https://doi.org/10.1002/bit.260270402	journal	April 1985
Biomechanical and Biochemical Pulping of Sugarcane Bagasse with Ceriporiopsis subvermispora Fungal and Xylanase Pretreatments Ramos, Juan; González, Mercedes; Ramírez, Felipe Journal of Agricultural and Food Chemistry, Vol. 49, Issue 3, p. 1180-1186 https://doi.org/10.1021/jf0011586	journal	March 2001
Melamine Deaminase and Atrazine Chlorohydrolase: 98 Percent Identical but Functionally Different Seffernick, J. L.; de Souza, M. L.; Sadowsky, M. J. Journal of Bacteriology, Vol. 183, Issue 8, p. 2405-2410 https://doi.org/10.1128/JB.183.8.2405-2410.2001	journal	April 2001
Purification and Properties of Acid Stable Xylanases from Aspergillus kawachii Ito, Kiyoshi; Ogasawara, Hironobu; Sugimoto, Takashi Bioscience, Biotechnology, and Biochemistry, Vol. 56, Issue 4, p. 547-550 https://doi.org/10.1271/bbb.56.547	journal	January 1992
Purification and Characterization of a Novel Thermo-Alkali-Stable Catalase from Thermus brockianus Thompson, Vicki S.; Schaller, Kastli D.; Apel, William A. Biotechnology Progress, Vol. 19, Issue 4, p. 1292-1299 https://doi.org/10.1021/bp034040t	journal	January 2003
Cloning and transcriptional analysis of the Thermoanaerobacter ethanolicus strain 39E maltose ABC transport system Jones, Chris R.; Ray, Myrna; Strobel, Herbert J. Extremophiles, Vol. 6, Issue 4, p. 291-299 https://doi.org/10.1007/s00792-001-0256-1	journal	March 2002
Overview and Evaluation of Fuel Ethanol from Cellulosic Biomass: Technology, Economics, the Environment, and Policy Lynd, Lee R. Annual Review of Energy and the Environment, Vol. 21, Issue 1, p. 403-465 https://doi.org/10.1146/annurev.energy.21.1.403	journal	November 1996
Interlaboratory testing of methods for assay of xylanase activity Bailey, Michael J.; Biely, Peter; Poutanen, Kaisa Journal of Biotechnology, Vol. 23, Issue 3, p. 257-270 https://doi.org/10.1016/0168-1656(92)90074-J	journal	May 1992
Regulation of the central glycolytic genes in Bacillus subtilis: binding of the repressor CggR to its single DNA target sequence is modulated by fructose-1,6-bisphosphate Doan, Thierry; Aymerich, Stéphane Molecular Microbiology, Vol. 47, Issue 6, p. 1709-1721 https://doi.org/10.1046/j.1365-2958.2003.03404.x	journal	March 2003
Quantitative Saccharification of Wood and Cellulose Saeman, Jerome F.; Bubl, Janet L.; Harris, Elwin E. Industrial & Engineering Chemistry Analytical Edition, Vol. 17, Issue 1, p. 35-37 https://doi.org/10.1021/i560137a008	journal	January 1945
Biotransformation of Toxic Organic and Inorganic Contaminants by Halophilic Bacteria Peyton, Brent M.; Mormile, Melanie R.; Alva, Victor Halophilic Microorganisms, p. 315-331 https://doi.org/10.1007/978-3-662-07656-9_23	book	January 2004
Xylanases, xylanase families and extremophilic xylanases Collins, Tony; Gerday, Charles; Feller, Georges FEMS Microbiology Reviews, Vol. 29, Issue 1, p. 3-23 https://doi.org/10.1016/j.femsre.2004.06.005	journal	January 2005
Molecular and biotechnological aspects of xylanases Kulkarni, Neeta; Shendye, Abhay; Rao, Mala FEMS Microbiology Reviews, Vol. 23, Issue 4, p. 411-456 https://doi.org/10.1111/j.1574-6976.1999.tb00407.x	journal	July 1999
Comparison of the economics of acid and enzymatic hydrolysis of newsprint Grethlein, Hans E. Biotechnology and Bioengineering, Vol. 20, Issue 4, p. 503-525 https://doi.org/10.1002/bit.260200404	journal	April 1978
Electrotransformation of Acidophilic, Heterotrophic, Gram-negative Bacteria Ward, Thomas E.; Eynard, Natalie; Teissié, Justin Electrotransformation of Bacteria, p. 94-103 https://doi.org/10.1007/978-3-662-04305-9_11	book	January 2000
Preliminary Investigation of Fungal Bioprocessing of Wheat Straw for Production of Straw-Thermoplastic Composites Thompson, David N.; Houghton, Tracy P.; Lacey, Jeffrey A. Biotechnology for Fuels and Chemicals, p. 423-436 https://doi.org/10.1007/978-1-4612-0057-4_35	book	January 2003
Partial acid hydrolysis of cellulosic materials as a pretreatment for enzymatic hydrolysis Knappert, Diane; Grethlein, Hans; Converse, Alvin Biotechnology and Bioengineering, Vol. 22, Issue 7, p. 1449-1463 https://doi.org/10.1002/bit.260220711	journal	July 1980
Isolation and characterization of a new family 42 β-galactosidase from the thermoacidophilic bacterium Alicyclobacillus acidocaldarius: Identification of the active site residues Di Lauro, Barbara; Strazzulli, Andrea; Perugino, Giuseppe Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Vol. 1784, Issue 2, p. 292-301 https://doi.org/10.1016/j.bbapap.2007.10.013	journal	February 2008
X-ray Structures of the Maltose–Maltodextrin-binding Protein of the Thermoacidophilic Bacterium Alicyclobacillus acidocaldarius Provide Insight into Acid Stability of Proteins Schäfer, Karsten; Magnusson, Ulrika; Scheffel, Frank Journal of Molecular Biology, Vol. 335, Issue 1, p. 261-274 https://doi.org/10.1016/j.jmb.2003.10.042	journal	January 2004
Industrial Scale-Up of pH-Controlled Liquid Hot Water Pretreatment of Corn Fiber for Fuel Ethanol Production Mosier, Nathan S.; Hendrickson, Richard; Brewer, Mark Applied Biochemistry and Biotechnology, Vol. 125, Issue 2, p. 77-98 https://doi.org/10.1385/ABAB:125:2:077	journal	January 2005
The Effect of Flow Rate of Compressed Hot Water on Xylan, Lignin, and Total Mass Removal from Corn Stover Liu, Chaogang; Wyman, Charles E. Industrial & Engineering Chemistry Research, Vol. 42, Issue 21, p. 5409-5416 https://doi.org/10.1021/ie030458k	journal	September 2003
The nature of lignocellulosics and their pretreatments for enzymatic hydrolysis Fan, L. T.; Lee, Young-Hyun; Gharpuray, M. M. Microbial Reactions, p. 157-187 https://doi.org/10.1007/3540116982_4	book	January 1982
Purification and characterization of an acidophilic xylanase from Aureobasidium pullulans var. melanigenum and sequence analysis of the encoding gene Ohta, Kazuyoshi; Moriyama, Satoshi; Tanaka, Hidenori Journal of Bioscience and Bioengineering, Vol. 92, Issue 3, p. 262-270 https://doi.org/10.1016/S1389-1723(01)80260-7	journal	January 2001
Pretreatment for enhanced hydrolysis of cellulosic biomass Grethlein, Hans E. Biotechnology Advances, Vol. 2, Issue 1, p. 43-62 https://doi.org/10.1016/0734-9750(84)90240-4	journal	January 1984
Oxygen effects on thermophilic microbial populations in biofilters treating nitric oxide containing off-gas streams Lee, Brady D.; Apel, William A.; Smith, William A. Environmental Progress, Vol. 20, Issue 3, p. 157-166 https://doi.org/10.1002/ep.670200311	journal	October 2001
Microbial β-Glucosidases: Cloning, Properties, and Applications Bhatia, Yukti; Mishra, Saroj; Bisaria, V. S. Critical Reviews in Biotechnology, Vol. 22, Issue 4, p. 375-407 https://doi.org/10.1080/07388550290789568	journal	January 2002
Fungal Upgrading of Wheat Straw for Straw-Thermoplastics Production Houghton, Tracy P.; Thompson, David N.; Hess, J. Richard Applied Biochemistry and Biotechnology, Vol. 113, Issue 1-3, p. 71-93 https://doi.org/10.1385/ABAB:113:1-3:071	journal	January 2004
Potential and utilization of thermophiles and thermostable enzymes in biorefining Turner, Pernilla; Mamo, Gashaw; Karlsson, Eva Microbial Cell Factories, Vol. 6, Issue 1, 9 https://doi.org/10.1186/1475-2859-6-9	journal	January 2007
Xylanases in bleaching: From an idea to the industry Viikari, Liisa; Kantelinen, Anne; Sundquist, Jorma FEMS Microbiology Reviews, Vol. 13, Issue 2-3, p. 335-350 https://doi.org/10.1111/j.1574-6976.1994.tb00053.x	journal	March 1994
Characterization of a β-glycosidase from the thermoacidophilic bacterium Alicyclobacillus acidocaldarius Lauro, Barbara Di; Rossi, Mosè; Moracci, Marco Extremophiles, Vol. 10, Issue 4, p. 301-310 https://doi.org/10.1007/s00792-005-0500-1	journal	April 2006
Glycosidases and glycosyl transferases in glycoside and oligosaccharide synthesis Crout, David H. G.; Vic, Gabin Current Opinion in Chemical Biology, Vol. 2, Issue 1, p. 98-111 https://doi.org/10.1016/S1367-5931(98)80041-0	journal	February 1998

Similar Records

Alteration and modulation of protein activity by varying post-translational modification

Patent · 2015 · OSTI ID:1171694

Characterization of post translational modifications of histones by electrospray ionization mass spectrometry

Conference · 1994 · OSTI ID:63849

A transient post-translational modification of active site cysteine alters binding properties of the parkinsonism protein DJ-1

Journal Article · 2018 · Biochemical and Biophysical Research Communications · OSTI ID:23103551

Related Subjects

59 BASIC BIOLOGICAL SCIENCES

Alteration and modulation of protein activity by varying post-translational modification

Citation Formats

References (60)

Similar Records

Related Subjects