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Title: Apparatus comprising magnetically actuated valves and uses thereof

Abstract

The present invention, in part, relates to an apparatus having a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded to an adhesive coating. The valve is opened using a magnetic force. The valve element includes a magnetic material or metal. In some examples, the valve is opened by bringing a magnet in proximity to the valve element to provide a magnetic force that delaminates the valve element from the adhesive coating. In particular, the apparatus can be useful for on-chip amplification and/or detection of various targets, including biological targets and any amplifiable targets. Such apparatuses and methods are useful for in-field or real-time detection of targets, especially in limited resource settings.

Inventors:
;
Publication Date:
Research Org.:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1261607
Patent Number(s):
9,389,231
Application Number:
14/157,335
Assignee:
Sandia Corporation (Albuquerque, NM) SNL-A
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Resource Relation:
Patent File Date: 2014 Jan 16
Country of Publication:
United States
Language:
English
Subject:
42 ENGINEERING; 59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Edwards, Thayne L., and Harper, Jason C.. Apparatus comprising magnetically actuated valves and uses thereof. United States: N. p., 2016. Web.
Edwards, Thayne L., & Harper, Jason C.. Apparatus comprising magnetically actuated valves and uses thereof. United States.
Edwards, Thayne L., and Harper, Jason C.. Tue . "Apparatus comprising magnetically actuated valves and uses thereof". United States. doi:. https://www.osti.gov/servlets/purl/1261607.
@article{osti_1261607,
title = {Apparatus comprising magnetically actuated valves and uses thereof},
author = {Edwards, Thayne L. and Harper, Jason C.},
abstractNote = {The present invention, in part, relates to an apparatus having a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded to an adhesive coating. The valve is opened using a magnetic force. The valve element includes a magnetic material or metal. In some examples, the valve is opened by bringing a magnet in proximity to the valve element to provide a magnetic force that delaminates the valve element from the adhesive coating. In particular, the apparatus can be useful for on-chip amplification and/or detection of various targets, including biological targets and any amplifiable targets. Such apparatuses and methods are useful for in-field or real-time detection of targets, especially in limited resource settings.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jul 12 00:00:00 EDT 2016},
month = {Tue Jul 12 00:00:00 EDT 2016}
}

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Works referenced in this record:

Electrically addressable diazonium-functionalized antibodies for multianalyte electrochemical sensor applications
journal, January 2008

  • Polsky, Ronen; Harper, Jason C.; Wheeler, David R.
  • Biosensors and Bioelectronics, Vol. 23, Issue 6, p. 757-764
  • DOI: 10.1016/j.bios.2007.08.013

Point-of-care nucleic acid testing for infectious diseases
journal, May 2011