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Title: Bisphenol-A sensors on polyimide fabricated by laser direct writing for on-site river water monitoring at attomolar concentration

Abstract

This work presents an aptamer-based, highly sensitive and specific sensor for atto- to femtomolar level detection of bisphenol A (BPA). Because of its widespread use in numerous products, BPA enters surface water from effluent discharges during its manufacture, use, and from waste landfill sites throughout the world. On-site measurement of BPA concentrations in water is important for evaluating compliance with water quality standards or environmental risk levels of the harmful compound in the environment. The sensor in this work is porous, conducting, interdigitated electrodes that are formed by laser-induced carbonization of flexible polyimide sheets. BPA-specific aptamer is immobilized on the electrodes as the probe, and its binding with BPA at the electrode surface is detected by capacitive sensing. The binding process is aided by ac electroosmotic effect that accelerates the transport of BPA molecules to the nanoporous graphene-like structured electrodes. The sensor achieved a limit of detection of 58.28 aM with a response time of 20 s. The sensor is further applied for recovery analysis of BPA spiked in surface water. In conclusion, this work provides an affordable platform for highly sensitive, real time, and field-deployable BPA surveillance critical to the evaluation of the ecological impact of BPA exposure.

Authors:
 [1];  [2];  [1];  [1];  [1];  [1];  [3];  [1];  [4];  [5]
  1. Univ. of Tennessee, Knoxville, TN (United States)
  2. Univ. of Tennessee, Knoxville, TN (United States); Sichuan Univ., Chengdu (People's Republic of China)
  3. Sichuan Univ., Chengdu (People's Republic of China)
  4. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
  5. Univ. of Tennessee, Knoxville, TN (United States); Beijing Univ. of Technology, Beijing (People's Republic of China)
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1261363
Grant/Contract Number:
AC05-00OR22725
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
ACS Applied Materials and Interfaces
Additional Journal Information:
Journal Name: ACS Applied Materials and Interfaces; Journal ID: ISSN 1944-8244
Publisher:
American Chemical Society
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; ac electroosmosis; aptasensor; capacitive sensing; laser direct writing; point of care

Citation Formats

Cheng, Cheng, Wang, Shutong, Wu, Jayne, Yu, Yongchao, Li, Ruozhou, Eda, Shigetoshi, Feng, Guoying, Chen, Jiangang, Lawrie, Benjamin J., and Hu, Anming. Bisphenol-A sensors on polyimide fabricated by laser direct writing for on-site river water monitoring at attomolar concentration. United States: N. p., 2016. Web. doi:10.1021/acsami.6b03743.
Cheng, Cheng, Wang, Shutong, Wu, Jayne, Yu, Yongchao, Li, Ruozhou, Eda, Shigetoshi, Feng, Guoying, Chen, Jiangang, Lawrie, Benjamin J., & Hu, Anming. Bisphenol-A sensors on polyimide fabricated by laser direct writing for on-site river water monitoring at attomolar concentration. United States. doi:10.1021/acsami.6b03743.
Cheng, Cheng, Wang, Shutong, Wu, Jayne, Yu, Yongchao, Li, Ruozhou, Eda, Shigetoshi, Feng, Guoying, Chen, Jiangang, Lawrie, Benjamin J., and Hu, Anming. 2016. "Bisphenol-A sensors on polyimide fabricated by laser direct writing for on-site river water monitoring at attomolar concentration". United States. doi:10.1021/acsami.6b03743. https://www.osti.gov/servlets/purl/1261363.
@article{osti_1261363,
title = {Bisphenol-A sensors on polyimide fabricated by laser direct writing for on-site river water monitoring at attomolar concentration},
author = {Cheng, Cheng and Wang, Shutong and Wu, Jayne and Yu, Yongchao and Li, Ruozhou and Eda, Shigetoshi and Feng, Guoying and Chen, Jiangang and Lawrie, Benjamin J. and Hu, Anming},
abstractNote = {This work presents an aptamer-based, highly sensitive and specific sensor for atto- to femtomolar level detection of bisphenol A (BPA). Because of its widespread use in numerous products, BPA enters surface water from effluent discharges during its manufacture, use, and from waste landfill sites throughout the world. On-site measurement of BPA concentrations in water is important for evaluating compliance with water quality standards or environmental risk levels of the harmful compound in the environment. The sensor in this work is porous, conducting, interdigitated electrodes that are formed by laser-induced carbonization of flexible polyimide sheets. BPA-specific aptamer is immobilized on the electrodes as the probe, and its binding with BPA at the electrode surface is detected by capacitive sensing. The binding process is aided by ac electroosmotic effect that accelerates the transport of BPA molecules to the nanoporous graphene-like structured electrodes. The sensor achieved a limit of detection of 58.28 aM with a response time of 20 s. The sensor is further applied for recovery analysis of BPA spiked in surface water. In conclusion, this work provides an affordable platform for highly sensitive, real time, and field-deployable BPA surveillance critical to the evaluation of the ecological impact of BPA exposure.},
doi = {10.1021/acsami.6b03743},
journal = {ACS Applied Materials and Interfaces},
number = ,
volume = ,
place = {United States},
year = 2016,
month = 6
}

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