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Oxidation of human cytochrome P450 1A2 substrates by Bacillus megaterium cytochrome P450 BM3
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Roles of key active-site residues in flavocytochrome P450 BM3
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April 1999 |
Generation of Human Chiral Metabolites of Simvastatin and Lovastatin by Bacterial CYP102A1 Mutants
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October 2010 |
Discrimination of thermophilic and mesophilic proteins
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January 2010 |
Construction of a thermostable cytochrome P450 chimera derived from self-sufficient mesophilic parents
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April 2007 |
Preparative use of isolated CYP102 monooxygenases—A critical appraisal
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August 2006 |
Thermostabilization of a Cytochrome P450 Peroxygenase
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September 2003 |
Structure of a cytochrome P450-redox partner electron-transfer complex
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March 1999 |
Efficient Screening of Cytochrome P450 BM3 Mutants for Their Metabolic Activity and Diversity toward a Wide Set of Drug-Like Molecules in Chemical Space
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June 2011 |
The molecular basis for the chemical denaturation of proteins by urea
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April 2003 |
The structure of the cytochrome p450BM-3 haem domain complexed with the fatty acid substrate, palmitoleic acid
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February 1997 |
Automated selection of stabilizing mutations in designed and natural proteins
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January 2012 |
Relative tolerance of mesostable and thermostable protein homologs to extensive mutation
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November 2006 |
Automatic atom type and bond type perception in molecular mechanical calculations
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October 2006 |
Crystal Structures of Human Cytochrome P450 3A4 Bound to Metyrapone and Progesterone
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July 2004 |
Evaluation of alkoxyresorufins as fluorescent substrates for cytochrome P450 BM3 and site-directed mutants
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June 2005 |
Enhanced Enzyme Kinetic Stability by Increasing Rigidity within the Active Site
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January 2014 |
Using Molecular Dynamics To Probe the Structural Basis for Enhanced Stability in Thermal Stable Cytochromes P450
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July 2010 |
A Self-Sufficient Peroxide-Driven Hydroxylation Biocatalyst
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July 2003 |
Improving stability of nitrile hydratase by bridging the salt-bridges in specific thermal-sensitive regions
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March 2013 |
Comparison of simple potential functions for simulating liquid water
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July 1983 |
Rational engineering of enzyme stability
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September 2004 |
Preliminary Characterization and Crystal Structure of a Thermostable Cytochrome P450 from Thermus thermophilus
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October 2002 |
Analysis of the structural stability of the multidomain enzyme flavocytochrome P-450 BM3
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September 1996 |
Quantum mechanically derived AMBER-compatible heme parameters for various states of the cytochrome P450 catalytic cycle
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October 2011 |
Evolutionary History of a Specialized P450 Propane Monooxygenase
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November 2008 |
The Carbon Monoxide-binding Pigment of Liver Microsomes
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July 1964 |
Comparison of multiple Amber force fields and development of improved protein backbone parameters
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November 2006 |
Crystal structures of metyrapone- and phenylimidazole-inhibited complexes of cytochrome P-450cam
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December 1987 |
Development and testing of a general amber force field
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January 2004 |
Stabilizing biocatalysts
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January 2013 |
Protein stability promotes evolvability
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March 2006 |
Prediction of protein conformation
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January 1974 |
Stability effects of mutations and protein evolvability
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October 2009 |
Identification of Mutant Asp251Gly/Gln307His of Cytochrome P450 BM3 for the Generation of Metabolites of Diclofenac, Ibuprofen and Tolbutamide
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February 2012 |
Enzyme stability and stabilization—Aqueous and non-aqueous environment
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October 2008 |
Molecular dynamics study of time-correlated protein domain motions and molecular flexibility: cytochrome P450BM-3
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September 1997 |
Factors enhancing protein thermostability
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March 2000 |
Identification of Critical Residues in Novel Drug Metabolizing Mutants of Cytochrome P450 BM3 Using Random Mutagenesis
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January 2007 |
XDS
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January 2010 |
Drug Oxidation by Cytochrome P450 BM3 : Metabolite Synthesis and Discovering New P450 Reaction Types
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August 2015 |
The stability of salt bridges at high temperatures: implications for hyperthermophilic proteins 1 1Edited by B. Honig
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November 1998 |
Human P450-like oxidation of diverse proton pump inhibitor drugs by ‘gatekeeper’ mutants of flavocytochrome P450 BM3
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May 2014 |
Pulse proteolysis: A simple method for quantitative determination of protein stability and ligand binding
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February 2005 |
A Quantitative Model of Thermal Stabilization and Destabilization of Proteins by Ligands
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October 2008 |
Probing Electron Transfer in Flavocytochrome P-450 BM3 and Its Component Domains
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July 1996 |
Critical Role of the Residue Size at Position 87 in H2O2-Dependent Substrate Hydroxylation Activity and H2O2 Inactivation of Cytochrome P450BM-3
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February 2001 |
PHENIX: a comprehensive Python-based system for macromolecular structure solution
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January 2010 |
Thermal unfolding molecular dynamics simulation ofEscherichia coli dihydrofolate reductase: Thermal stability of protein domains and unfolding pathway
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January 2002 |
Key Mutations Alter the Cytochrome P450 BM3 Conformational Landscape and Remove Inherent Substrate Bias
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August 2013 |
Similarity and Difference in the Unfolding of Thermophilic and Mesophilic Cold Shock Proteins Studied by Molecular Dynamics Simulations
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October 2006 |
Heterotropic and homotropic cooperativity by a drug-metabolising mutant of cytochrome P450 BM3
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August 2006 |
Protein rigidity and thermophilic adaptation
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January 2011 |
Increasing Temperature Accelerates Protein Unfolding Without Changing the Pathway of Unfolding
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September 2002 |
P450 BM3 (CYP102A1): connecting the dots
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January 2012 |
Engineering Bacterial Cytochrome P450 (P450) BM3 into a Prototype with Human P450 Enzyme Activity Using Indigo Formation
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January 2010 |
Structural rationalization of novel drug metabolizing mutants of cytochrome P450 BM3
- Stjernschantz, Eva; van Vugt-Lussenburg, Barbara M. A.; Bonifacio, Alois
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Proteins: Structure, Function, and Bioinformatics, Vol. 71, Issue 1
https://doi.org/10.1002/prot.21697
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April 2008 |
Improving Kinetic or Thermodynamic Stability of an Azoreductase by Directed Evolution
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January 2014 |
Phaser crystallographic software
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July 2007 |
Generation of the Human Metabolite Piceatannol from the Anticancer-Preventive Agent Resveratrol by Bacterial Cytochrome P450 BM3
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February 2009 |
Regioselectivity and Activity of Cytochrome P450 BM-3 and Mutant F87A in Reactions Driven by Hydrogen Peroxide
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October 2002 |
PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data
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June 2013 |
The Carbon Monoxide-binding Pigment of Liver Microsomes
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July 1964 |