Broad spectrum antibiotic compounds and use thereof

Patent · Tue Jul 05 00:00:00 EDT 2016

OSTI ID:1260252

Koglin, Alexander; Strieker, Matthias

The discovery of a non-ribosomal peptide synthetase (NRPS) gene cluster in the genome of Clostridium thermocellum that produces a secondary metabolite that is assembled outside of the host membrane is described. Also described is the identification of homologous NRPS gene clusters from several additional microorganisms. The secondary metabolites produced by the NRPS gene clusters exhibit broad spectrum antibiotic activity. Thus, antibiotic compounds produced by the NRPS gene clusters, and analogs thereof, their use for inhibiting bacterial growth, and methods of making the antibiotic compounds are described.

• Research Organization: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC52-06NA25396
• Assignee: Los Alamos National Security, LLC (Los Alamos, NM)
• Patent Number(s): 9,382,294
• Application Number: 14/771,710
• OSTI ID: 1260252
• Resource Relation: Patent File Date: 2014 Feb 28
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
60 APPLIED LIFE SCIENCES