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Title: Host cells and methods for producing 1-deoxyxylulose 5-phosphate (DXP) and/or a DXP derived compound

Patent ·
OSTI ID:1260248
; ; ;

The present invention provides for a genetically modified host cell capable of producing 1-deoxyxylulose 5-phosphate or 1-deoxy-D-xylulose 5-phosphate (DXP) (12), and optionally one or more DXP derived compounds, comprising: (a) a mutant RibB, or functional variant thereof, capable of catalyzing xylulose 5-phosphate and/or ribulose 5-phosphate to DXP, or (b) a YajO, or functional variant thereof, and a XylB, or functional variant thereof.

Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC02-05CH11231
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Number(s):
9,382,553
Application Number:
13/587,826
OSTI ID:
1260248
Resource Relation:
Patent File Date: 2012 Aug 16
Country of Publication:
United States
Language:
English

References (6)

Biosynthesis of isoprenoids via the non-mevalonate pathway journal June 2004
Computational Analysis of the Evolution of 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase, an Important Enzyme in Plant Terpene Biosynthesis journal May 2010
Engineering a mevalonate pathway in Escherichia coli for production of terpenoids journal June 2003
Phosphorylation of 1-deoxy-D-xylulose by D-xylulokinase of Escherichia coli: journal January 2001
Production Of Isoprenoids patent-application November 2008
Host Cells and Methods for Producing Isoprenyl Alkanoates patent-application July 2010

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