Development of the Plutonium-DTPA biokinetic model
- CH2-WG Idaho, LLC, Idaho Falls, ID (United States)
- Idaho State Univ., Pocatello, ID (United States)
Estimating radionuclide intakes from bioassays following chelation treatment presents a challenge to the dosimetrist due to the observed excretion enhancement of the particular radionuclide of concern, where no standard biokinetic model exists. This document provides a Pu-DTPA biokinetic model that may be used for making such determination for plutonium intakes. The Pu-DTPA biokinetic model is intended to supplement the standard recommended biokinetic models. The model was used to evaluate several chelation strategies that resulted in providing recommendations for effective treatment. These recommendations supported early treatment for soluble particle inhalations and an initial 3-day treatment series of DTPA treatments for wounds. Several late chelation strategies were also compared where reduced treatment frequencies proved to be as effective as multiple treatments. Furthermore, the Pu-DTPA biokinetic model can be used to assist in estimating initial intakes of transuranic radionuclides, and for studying the effects of different treatment strategies.
- Research Organization:
- CH2-WG Idaho, LLC, Idaho Falls, ID (United States)
- Sponsoring Organization:
- USDOE Office of Environmental Management (EM)
- Contributing Organization:
- Enter names of organizations that provided significant assistance but not direct funding
- Grant/Contract Number:
- AC07-05ID14516
- OSTI ID:
- 1256081
- Journal Information:
- Health Physics, Vol. 108, Issue 6; Related Information: (Provide citations for supplementary items published with journal articles, or any other citation directly supporting the document you are submitting. Or, see the Related DOIs field below.); ISSN 0017-9078
- Publisher:
- Health Physics SocietyCopyright Statement
- Country of Publication:
- United States
- Language:
- English
Web of Science
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